A5013294261- Economic and Financial Impacts of Cancer
- Health Systems, Economic Evaluations, Quality of Life
- Cancer Genomics and Diagnostics
- Lung Cancer Treatments and Mutations
- Cancer Immunotherapy and Biomarkers
- Global Cancer Incidence and Screening
- COVID-19 and healthcare impacts
- Immune Cell Function and Interaction
- IL-33, ST2, and ILC Pathways
- Immune cells in cancer
- Advances in Oncology and Radiotherapy
- Advanced Breast Cancer Therapies
- Colorectal Cancer Screening and Detection
- Helicobacter pylori-related gastroenterology studies
- Lung Cancer Research Studies
- Genetic factors in colorectal cancer
- CAR-T cell therapy research
- Lung Cancer Diagnosis and Treatment
- Histone Deacetylase Inhibitors Research
- Pharmaceutical Economics and Policy
- Peptidase Inhibition and Analysis
- Cutaneous Melanoma Detection and Management
- Cancer Mechanisms and Therapy
- Melanoma and MAPK Pathways
- Biomedical Text Mining and Ontologies
The University of Melbourne
2020-2025
Peter MacCallum Cancer Centre
2020-2025
Cancer Services
2024
Melbourne Health
2021-2024
Victorian Comprehensive Cancer Centre
2022
University of Oxford
2013-2019
John Radcliffe Hospital
2013-2015
Patients with inflammatory bowel disease (IBD) have an increased risk of colon cancer. However, the immune cells and cytokines that mediate transition from intestinal inflammation to cancer are poorly understood. We show bacteria-induced is accompanied by differential accumulation IL-17(+)IL-22(+) colonic innate lymphoid (cILCs), which phenotypically distinct LTi NK-22 cells, their depletion in mice dysplastic blocks development invasive Analysis functional role Type 17 shows although...
The role of intestinal eosinophils in immune homeostasis is enigmatic and the molecular signals that drive them from protective to tissue damaging are unknown. Most commonly associated with Th2 cell-mediated diseases, we describe a for as crucial effectors interleukin-23 (IL-23)-granulocyte macrophage colony-stimulating factor (GM-CSF) axis colitis. Chronic inflammation was characterized by increased bone marrow eosinopoiesis accumulation activated eosinophils. IL-5 blockade or eosinophil...
Abstract Regulation of the programming tumour-associated macrophages (TAMs) controls tumour growth and anti-tumour immunity. We examined role FGF2 in that regulation. Tumours mice genetically deficient low-molecular weight (FGF2 LMW ) regress dependent on T cells. Yet, TAMS not cells express FGF receptors. Bone marrow derived-macrophages from Fgf2 LMW−/− co-injected with cancer reduce more inflammatory cytokines. is induced microenvironment following fractionated radiation murine tumours...
Interactions between the host and its microbiota are of mutual benefit promote health. Complex molecular pathways underlie this dialog, but identity microbe-derived molecules that mediate mutualistic state remains elusive. Helicobacter hepaticus is a member mouse intestinal tolerated by host. In absence an intact IL-10 signaling, H. induces IL-23-driven inflammatory response in intestine. Here we investigate interactions immune cells may mutualism, molecule(s) involved. Our results show...
Decreased cancer incidence and reported changes to clinical management indicate that the COVID-19 pandemic has delayed diagnosis treatment. This study aimed develop apply a flexible model estimate impact of treatment on survival outcomes healthcare costs based shift in disease stage at initiation.A was developed made publicly available population-level health economic by extrapolating weighing stage-specific distribution stages initiation. It applied 3- 6-month delays Australian data for I...
Abstract Inflammatory bowel disease (IBD) are heterogenous disorders of the gastrointestinal tract caused by a spectrum genetic and environmental factors. In mice, overlapping regions chromosome 3 have been associated with susceptibility to IBD-like pathology, including locus called Hiccs . However, specific gene that controls remains unknown. Here we identify gene, Alpk1 (encoding alpha kinase 1), as potent regulator intestinal inflammation. response infection commensal pathobiont...
To report clinician-perceived changes to cancer service delivery in response COVID-19.Multidisciplinary Australasian clinician survey collaboration with the European Society of Medical Oncology.Between May and June 2020 clinicians from 70 countries were surveyed; majority Europe (n=196; 39%) 1846 COVID-19 cases per million people, Australia (AUS)/New Zealand (NZ) (n=188; 38%) 267/236 Asia (n=75; 15%) 121 at time distribution.Medical oncologists (n=372; 74%), radiation (n=91; 18%) surgical...
Complex genomic profiling (CGP) has transformed cancer treatment decision making, yet there is a lack of robust and quantifiable evidence for how utilisation CGP improves patient outcomes. This study evaluated cohort level clinical effectiveness to improve overall survival (OS) in real-world advanced patients using registry-based matched control population. Two cohorts refractory were seen consecutive series early phase trial enrolment consideration. The first (CGP group) accessed tumour via...
Abstract Background Decreased cancer incidence and reported changes to clinical management indicate that the COVID-19 pandemic will result in diagnostic treatment delays for patients. We aimed develop a flexible model estimate impact of delayed diagnosis initiation on survival outcomes healthcare costs based shift disease stage at initiation. Methods The stage-shift estimates population-level health economic by weighting stage-specific distribution stages initiation, assuming lead...
The COVID-19 pandemic has had a vast impact on cancer service delivery around the world. Previously reported results from our international survey of oncology clinicians, conducted through March-April 2020, found that clinicians altering management in both curative and palliative settings not proportion to case burden their region practice. This follow-up survey, 27th September 7th November aimed explore how attitudes practices evolved over 2020 period.Participants were medical, radiation...
rearranged advanced NSCLC (aNSCLC) represents 4% of all NSCLCs, and multiple ALK-targeted therapies (ALK-inhibitors) are now available for use. Little is known about changes in treatment patterns, or how prognostic factors sequence therapy may impact overall survival the real-world setting. We aim to describe initial subsequent treatments used, outcomes, factors, on largest (N = 739) cohort patients with ALK+ aNSCLC reported literature.
ObjectivesEffective healthcare planning, resource allocation, and budgeting require accurate predictions of the number patients needing treatment at specific cancer stages lines. The Predicting Population Health Economic Impact Current New Cancer Treatments (PRIMCAT) for Colorectal (CRC) simulation model (PRIMCAT-CRC) was developed to meet this requirement all CRC relevant molecular profiles in Australia.MethodsReal-world data were used estimate utilization time-to-event distributions. This...
We study how clinical and socioeconomic factors influence colorectal cancer (CRC) costs for patients Medicare in Australia. The seeks to extend the limited Australian literature on CRC by analysing comprehensive patient-level medical services pharmaceutical cost data.