A5000683586- Immune Cell Function and Interaction
- T-cell and B-cell Immunology
- Immunodeficiency and Autoimmune Disorders
- Pediatric Hepatobiliary Diseases and Treatments
- Autoimmune and Inflammatory Disorders Research
- Infant Nutrition and Health
- Parvovirus B19 Infection Studies
- Pharmaceutical studies and practices
- Glycosylation and Glycoproteins Research
- Neonatal Respiratory Health Research
- Genetics and Neurodevelopmental Disorders
- Prenatal Screening and Diagnostics
- Child Nutrition and Water Access
- Amyotrophic Lateral Sclerosis Research
- Cancer, Hypoxia, and Metabolism
- Adolescent and Pediatric Healthcare
- Ubiquitin and proteasome pathways
- RNA regulation and disease
- Melanoma and MAPK Pathways
- PI3K/AKT/mTOR signaling in cancer
- CAR-T cell therapy research
- Connective tissue disorders research
- Monoclonal and Polyclonal Antibodies Research
- Congenital limb and hand anomalies
- Prostate Cancer Treatment and Research
Zunyi Medical University
2020-2025
First People’s Hospital of Zunyi
2024-2025
Children's Hospital of Chongqing Medical University
2015-2024
Chongqing Medical University
2015-2024
China International Science and Technology Cooperation
2020-2024
Affiliated Hospital of Zunyi Medical College
2023
Abstract The involvement of B lymphocytes in the pathogenesis rheumatoid arthritis (RA) is well-established, with their early and aberrant activation being a crucial factor. However, mechanisms underlying this abnormal RA remain incompletely understood. In study, we identified significant reduction MAPK4 expression both patients collagen-induced (CIA) mouse models, which correlates disrupted cell activation. Using knockout (KO) mice, demonstrated that intrinsically promotes differentiation...
This study systematically explored the role of NEDD8 in pediatric acute myeloid leukemia (AML) through patient sample analysis, database mining, and vitro experiments. Our results demonstrated that was significantly overexpressed newly diagnosed AML patients associated with poor survival outcomes. Functional enrichment analysis TARGET further revealed a strong correlation between cancer-related pathways. In experiments showed knockdown inhibited proliferation cells (THP-1 MV4-11) induced...
Abstract Objective To investigate the clinical characteristics of neonatal necrotizing enterocolitis (NEC) complicated by intestinal perforation and predict incidence in NEC. Methods Neonates diagnosed with NEC at Affiliated Hospital Zunyi Medical University from January 2012 to May 2022 were enrolled, data collected analyzed retrospectively. The patients divided into two groups based on occurrence or not. Mann-Whitney U tests, t-tests, chi-square fisher’s exact tests performed between-group...
Abstract Progranulin (PGRN) plays a critical role in bronchial asthma and the function of various immune cells. However, mechanisms by which PGRN influences B‐cell receptor (BCR) signaling immunoglobulin E(IgE) production are not fully understood. The study aimed to elucidate molecular through affects BCR signaling, differentiation, IgE production. A knockout mouse model, along with techniques including flow cytometry, creation bone marrow chimeric total internal reflection fluorescence...
Abstract Background AKT2 is one of the key molecules that involves in insulin-induced signaling and development cancer. In B cells, function unclear. Methods this study, we used knockout mice model to study role BCR cell differentiation. Results promotes early activation cells by enhancing actin remodeling. from KO exhibited defective spreading clustering upon stimulation vitro. Disruption Btk-mediated caused impaired differentiation germinal center serum levels both sepecific IgM IgG were...
Cell metabolism is crucial for orchestrating the differentiation and function of regulatory T cells (Tregs). However, underlying mechanism that coordinates cell to regulate Treg activity not completely understood. As a pivotal molecule in lipid metabolism, role SHIP-1 Tregs remains unknown. In this study, we found KO mice (SHIP-1 specifically deleted cells) had severe autoimmunity with increased thymus disrupted peripheral homeostasis. Mechanistically, CD4Cre Ship-1flox/flox were have...
Abstract Objective To investigate the clinical characteristics of neonatal necrotizing enterocolitis (NEC) complicated by intestinal perforation and predict incidence in NEC. Methods Neonates diagnosed with NEC at Affiliated Hospital Zunyi Medical University from January 2012 to May 2022 were enrolled, data collected analyzed retrospectively. The patients divided into two groups based on occurrence or not. Mann-Whitney U tests, t-tests, chi-square fisher's exact tests performed between-group...
Objective: To establish a prediction Nomogram based on prognostic factors for children with hemophagocytic lymphohistiocytosis (HLH). Methods: A retrospective analysis of pediatric HLH cases diagnosed at the Affiliated Hospital Zunyi Medical University between January 2012 and December 2022 was conducted. Cox regression used to identify patients. The C-index, ROC curve, AUC were evaluate discrimination model. DCA clinical application value Results: total 133 secondary patients included in...
Abstract Cell metabolism is crucial for orchestrating the differentiation and function of regulatory T cells (Tregs). However, underlying signaling mechanism that coordinates cell to regulate Treg activity not completely understood. As a pivotal molecule in lipid metabolism, role SHIP-1 has been studied extensively B CD4 cells, yet its Tregs remains unknown. In this study, we generated “SHIP-1 KO mice” have specifically deleted by crossing Foxp3 YFP-cre mice with fl/fl mice. Surprisingly,...