A5015274962- Gut microbiota and health
- Genomics and Phylogenetic Studies
- Bacterial Identification and Susceptibility Testing
- Bacteriophages and microbial interactions
- Pneumonia and Respiratory Infections
- Clostridium difficile and Clostridium perfringens research
- Streptococcal Infections and Treatments
- Microbial Community Ecology and Physiology
- Infective Endocarditis Diagnosis and Management
- Microbial infections and disease research
- Helicobacter pylori-related gastroenterology studies
- Probiotics and Fermented Foods
- Asthma and respiratory diseases
- Antibiotic Resistance in Bacteria
- SARS-CoV-2 detection and testing
- SARS-CoV-2 and COVID-19 Research
- Microbial bioremediation and biosurfactants
- Pediatric health and respiratory diseases
- Plant Pathogenic Bacteria Studies
- COVID-19 Clinical Research Studies
- Enterobacteriaceae and Cronobacter Research
- Veterinary medicine and infectious diseases
- Tryptophan and brain disorders
- Cytomegalovirus and herpesvirus research
- Vibrio bacteria research studies
University of Gothenburg
2014-2022
Sahlgrenska University Hospital
2019-2020
Region Västra Götaland
2020
Karolinska Institutet
2008-2014
Swedish Institute
2007-2014
Antibiotic administration is the standard treatment for bacterium Helicobacter pylori, main causative agent of peptic ulcer disease and gastric cancer. However, long-term consequences this on human indigenous microbiota are relatively unexplored. Here we studied short- effects clarithromycin metronidazole treatment, a commonly used therapy regimen against H. in throat lower intestine. The bacterial compositions samples collected over four-year period were monitored by analyzing 16S rRNA gene...
Humans host complex microbial communities believed to contribute health maintenance and, when in imbalance, the development of diseases. Determining composition patients and healthy controls may thus provide novel therapeutic targets. For this purpose, high-throughput, cost-effective methods for microbiota characterization are needed. We have employed 454-pyrosequencing a hyper-variable region 16S rRNA gene combination with sample-specific barcode sequences which enables parallel in-depth...
<h3>Objective</h3> The early intestinal microbiota exerts important stimuli for immune development, and a reduced microbial exposure as well caesarean section (CS) has been associated with the development of allergic disease. Here we address how in infants is affected by mode delivery, relate differences colonisation patterns to maturation balanced Th1/Th2 response. <h3>Design</h3> postnatal pattern was investigated 24 infants, born vaginally (15) or CS (nine). were characterised using...
Low total diversity of the gut microbiota during first year life is associated with allergic diseases in infancy, but little known how early microbial related to disease later school age.To assess and characterize dominant bacteria stool relation prevalence different age, such as asthma, rhinoconjunctivitis (ARC) eczema.The composition was analysed barcoded 16S rDNA 454 pyrosequencing samples at 1 week, month 12 months age 47 infants which were subsequently assessed for skin prick test...
Scientific Report18 December 2014Open Access Source Data The composition of the gut microbiota shapes colon mucus barrier Hedvig E Jakobsson Department Medical Biochemistry, University Gothenburg, Sweden Search for more papers by this author Ana M Rodríguez-Piñeiro André Schütte Anna Ermund Preben Boysen Food Safety and Infection Biology, Faculty Veterinary Medicine Biosciences, Norwegian Life Sciences, Oslo, Norway Mats Bemark Microbiology Immunology, Clinical Immunology Transfusion...
ABSTRACT The taxonomic composition of a microbial community can be deduced by analyzing its rRNA gene content by, e.g., high-throughput DNA sequencing or chips. Such methods typically are based on PCR amplification sequences using broad-taxonomic-range primers. In these analyses, the use optimal primers is crucial for achieving an unbiased representation composition. Here, we present computer program DegePrime that, each position multiple sequence alignment, finds degenerate oligomer as high...
We present the first complete, closed genome sequences of Streptococcus pyogenes strains NCTC 8198
A range of methodologies may be used for analyzing bacteria, depending on the purpose and level resolution needed. The capability recognition species distinctions within complex spectrum bacterial diversity is necessary progress in microbiological research. In clinical settings, accurate, rapid cost-effective methods are essential early efficient treatment infections. Characterization identification microorganisms, using, bottom-up proteomics, or “proteotyping”, relies species-unique...
Mass spectrometry (MS) and proteomics offer comprehensive characterization identification of microorganisms discovery protein biomarkers that are applicable for diagnostics infectious diseases. The use is widely applied in the clinic peptide increasingly being investigated applications clinical laboratory. Respiratory-tract infections a predominant cause medical treatment, although, assessments standard laboratory protocols time-consuming often inadequate reliable diagnoses. Novel methods,...
Large-scale chemoprevention of peptic ulcer disease and gastric cancer through eradication Helicobacter pylori would expose large population groups to antibiotics, which raises concerns about possible dissemination antibiotic resistance. The objective this cohort study was determine whether a triple therapy, containing omeprazole, clarithromycin, metronidazole, H. infection increases the prevalence macrolide resistance in normal microbiota. 85 patients with verified 12 dyspeptic without...
Two strains included in a whole-genome sequencing project for methicillin-resistant Staphylococcus aureus (MRSA) were identified as non-Staphylococcus when the sequences analysed using bioinformatics software ALEX (www.1928diagnostics.com, Gothenburg, Sweden). Sequencing of sodA gene these them argenteus. The collection MRSA western Sweden was checked additional this species. A total 18 S. argenteus isolated between 2011 and December 2017 identified.
The family Enterobacteriaceae is a taxonomically diverse and widely distributed containing many human commensal pathogenic species that are known to carry transferable antibiotic resistance determinants. Characterization of novel taxa within this great importance in order understand the associated health risk provide better treatment options. aim present study was characterize Gram-negative bacterial strain (CCUG 66741) belonging Enterobacteriaceae, isolated from wound infection an adult...
Abstract Infection in the central nervous system is a severe condition associated with high morbidity and mortality. Despite ample testing, majority of encephalitis meningitis cases remain undiagnosed. Metagenomic sequencing cerebrospinal fluid has emerged as an unbiased approach to identify rare microbes novel pathogens. However, several major hurdles remain, including establishment individual limits detection, removal false positives implementation universal controls. Twenty-one samples,...
Background Reinfections with SARS-CoV-2 have been reported and most cases were classified as mild. Reports of persistent infection are rare.
Abstract Objective: Effective infection prevention and control (IPC) measures are key for protecting patients from nosocomial infections require knowledge of transmission mechanisms in different settings. We performed a detailed outbreak analysis the outcome coronavirus disease 2019 (COVID-19) geriatric ward by combining whole-genome sequencing (WGS) with epidemiological data. Design: Retrospective cohort study. Setting: Tertiary-care hospital. Participants: Patients healthcare workers...
ABSTRACT Moraxella catarrhalis is a Gram-negative commensal and pathogenic bacterium found in the human respiratory tract. It associated with otitis media tract infections. Here, we report draft genome sequence of M. type strain CCUG 353 T , composed 18 contigs total size 1.89 Mb.
ABSTRACT The draft genome sequence has been determined for an extended-spectrum-β-lactamase (ESBL)-producing ( bla CTX-M-15 ) Escherichia coli strain (CCUG 62462), composed of 119 contigs and a total size 5.27 Mb. This E. is serotype O25b type 131, pandemic clonal group, causing worldwide antimicrobial-resistant infections.
The genome sequences of Pseudomonas balearica strains LS401 (CCUG 66666) and st101 66667) have been determined. were isolated as naphthalene degraders from polluted marine sediment a sample an oil refinery site, respectively. These genomes provide essential data about the biodegradation capabilities ecological implications P. balearica.
Streptococcus gordoniitype strain CCUG 33482(T)is a member of theStreptococcus mitisgroup, isolated from case subacute bacterial endocarditis. Here, we report the draft genome sequence ofS. gordoniiCCUG 33482(T), composed 41 contigs total size 2.15 Mb with 2,061 annotated coding sequences.
Streptococcus pneumoniae is a pathogenic bacterium found most commonly in the respiratory tract of humans and common cause pneumonia bacterial meningitis. Here, we report draft genome sequences six S. strains: CCUG 1350, 7206, 11780, 33774, 35180, 35272.
Abstract We present the first complete, closed genome sequences of Streptococcus pyogenes strains NCTC 8198 T and CCUG 4207 , type strain species genus an important human pathogen that causes a wide range infectious diseases. S. are derived from deposit same at two different culture collections. was sequenced, using PacBio platform; sequence assembled de novo HGAP. sequenced hybrid assembly generated, SPAdes, combining Illumina Oxford Nanopore reads. Both strategies, yielded 1,914,862 bp,...