A5047324585- Down syndrome and intellectual disability research
- Renal cell carcinoma treatment
- Renal and related cancers
- Genomic variations and chromosomal abnormalities
- Epigenetics and DNA Methylation
- Bladder and Urothelial Cancer Treatments
- Genetics and Neurodevelopmental Disorders
- Plant Molecular Biology Research
- Plant Gene Expression Analysis
- Chromosomal and Genetic Variations
- Plant Reproductive Biology
- Genetic and Kidney Cyst Diseases
- Insect and Pesticide Research
- CRISPR and Genetic Engineering
- Biochemical and Structural Characterization
- Photosynthetic Processes and Mechanisms
- Antimicrobial Peptides and Activities
- Insect Resistance and Genetics
- Protein Degradation and Inhibitors
- Immunodeficiency and Autoimmune Disorders
- Hearing Loss and Rehabilitation
- Immune responses and vaccinations
- Elder Abuse and Neglect
- Cancer-related gene regulation
- Signaling Pathways in Disease
Second Xiangya Hospital of Central South University
2024-2025
Central South University
2024-2025
Cancer Genetics (United States)
2015-2024
University at Buffalo, State University of New York
2022
Roswell Park Comprehensive Cancer Center
2015-2018
Texas A&M University
2013
State Key Laboratory of Plant Genomics
2008-2012
Institute of Genetics and Developmental Biology
2008-2012
Chinese Academy of Sciences
2008-2012
Liaoning Normal University
2007-2011
Down syndrome (DS), caused by trisomy 21, is the most common chromosomal disorder associated with developmental cognitive deficits. Despite intensive efforts, genetic mechanisms underlying deficits remain poorly understood, and no treatment has been proven effective. The previous mouse-based experiments suggest that so-called critical region of human chromosome 21 an important for this phenotype, which demarcated Setd4/Cbr1 Fam3b/Mx2. We first confirmed importance Cbr1-Fam3b using compound...
Recent studies have shown that molecular control of inner floral organ identity appears to be largely conserved between monocots and dicots, but little is known regarding the mechanism underlying development monocot outer organ, a unique structure in grasses. In this study, we report cloning rice EXTRA GLUME1 (EG1) gene, putative lipase gene specifies empty-glume fate meristem determinacy. addition affecting number empty glumes, mutations EG1 caused ectopic organs formed at each whorl or...
Rice is a very important food staple that feeds more than half the world's population. Two major Asian cultivated rice (Oryza sativa L.) subspecies, japonica and indica, show significant phenotypic variation in their stress responses. However, molecular mechanisms underlying this are still largely unknown. A common link among different stresses they produce an oxidative burst result increase of reactive oxygen species (ROS). In study, methyl viologen (MV) as ROS agent was applied to...
Long interspersed elements (LINEs), through both self-mobilization and trans -mobilization of short processed pseudogenes, have made an indelible impact on the structure function human genome. One consequence is creation new CpG islands (CGIs). In fact, more than half all CGIs in genome are associated with repetitive DNA, three-quarters which derived from retrotransposons. However, little known about epigenetic newly inserted CGIs. We utilized a transgenic LINE-1 mouse model tracked DNA...
As an aneuploidy, trisomy is associated with mammalian embryonic and postnatal abnormalities. Understanding the underlying mechanisms involved in mutant phenotypes broadly important may lead to new strategies treat clinical manifestations individuals trisomies, such as 21 [Down syndrome (DS)]. Although increased gene dosage effects because of a account for phenotypes, there also possibility that phenotypic consequences can arise presence freely segregating extra chromosome its own...
Background: Collagen represents a prominent constituent of the tumor’s extracellular matrix (ECM). Nonetheless, its correlation with molecular subtype attributes clear cell renal carcinoma (ccRCC) remains elusive. Our objective is to delineate collagen-associated subtypes and further construct diagnostic model, offering insights conducive precise selection ccRCC patients for immunotherapeutic interventions. Methods: We performed unsupervised non-negative factorization (NMF) analysis on...
Plant diurnal oscillation is a 24-hour period based variation. The correlation between genes and biological pathways was widely revealed by microarray analysis in different species. Rice (Oryza sativa) the major food staple for about half of world's population. rice flag leaf essential providing photosynthates to grain filling. However, there still no comprehensive view transcriptome leaves. In this study, we applied monitor rhythmically expressed seedling We developed new computational...
High abundance proteins like ribulose-1,5-bisphosphate carboxylase oxygenase (Rubisco) impose a consistent challenge for the whole proteome characterization using shot-gun proteomics. To address this challenge, we developed and evaluated Polyethyleneimine Assisted Rubisco Cleanup (PARC) as new method by combining both abundant protein removal fractionation. The approach was applied to plant insect interaction study validate platform investigate mechanisms defense against herbivorous insects....
Down syndrome (DS) is the most common genetic cause of Alzheimer's disease (AD) due to trisomy for all or part human chromosome 21 (Hsa21). It also associated with other phenotypes including distinctive facial features, cardiac defects, growth delay, intellectual disability, immune system abnormalities, and hearing loss. All adults DS demonstrate AD-like brain pathology, amyloid plaques neurofibrillary tangles, by age 40 dementia typically 60. There compelling evidence that increased APP...
Synovial sarcoma is the most common pediatric non-rhabdomyosarcoma soft tissue and accounts for about 8-10% of all in childhood adolescence. The presence a chromosomal translocation-associated SS18-SSX-fusion gene causally linked to development primary synovial sarcoma. Metastases occur approximately 50-70% cases with yet unknown mechanisms, which led 70-80% mortality rate five years. To explore possibilities investigate metastatic mechanisms sarcoma, we carried out first genome-wide search...
Abstract Background Partial nephrectomy (PN) is usually recommended for T1 stage clear cell renal carcinoma (ccRCC) regardless of the nuclear grades. However, question remains unresolved as to whether PN non-inferior RN in patients with T1-ccRCC at higher risk recurrence. In fact, we found that high grades treated had poorer prognosis compared those radical (RN). Therefore, this study was designed evaluate associations and four grade subsets oncologic outcomes. Methods A retrospective...
Recent epidemiological studies suggest that individuals with Down syndrome are more susceptible to SARS-CoV-2 infection and have higher rates of hospitalization mortality than the general population. However, main drivers behind these disparate health outcomes remain unknown. Herein, we performed experimental infections in a well-established mouse model syndrome. We observed similar replication kinetics dissemination primary secondary organs between mice without syndrome, suggesting both...
// Chunhong Liu 1, * , Tao Yu 2, Zhuo Xing Xiaoling Jiang Yichen Li 1 Annie Pao Justin Mu Paul K. Wallace 3 George Stoica 4 Andrei V. Bakin 5 and Y. Eugene 6 The Children's Guild Foundation Down Syndrome Research Program, Genetics Genomics Program Department of Cancer Genomics, Roswell Park Institute, Buffalo, NY 14263, USA 2 Medical Genetics, Tongji College, Huazhong University Science Technology, Wuhan, Hubei 430030, China Flow Image Cytometry, Pathobiology, Texas A&M University, College...
Hearing impairment is a cardinal feature of Down syndrome (DS), but its clinical manifestations have been attributed to multiple factors. Murine models could provide mechanistic insights on various causes hearing loss in DS. To investigate mechanisms DS the absence cadherin 23 mutation, we backcrossed our mice, Dp(16)1Yey, onto normal-hearing CBA/J mice and evaluated their auditory function. Body weights wild type (WT) were similar at 3-months age, 9-months, WT weighed 30% more than mice....
ABSTACT: The effects of melittin on growth and bacteriostasis four pathogens were extensively investigated using scanning electron microscopy (SEM) transmission (TEM). results indicated that the had a marked bacteriostatic effect pathogenic bacteria. Among these, E. cacotowora was influenced most powerfully quickly, yeast F. fulva second, S. aureus inhibited by low concentration but killed high concentration. It observed in experiments bacteria three ways. One pore formation. After...