A5022661129- Plant Toxicity and Pharmacological Properties
- Nasolacrimal Duct Obstruction Treatments
- Bone Metabolism and Diseases
- Head and Neck Surgical Oncology
- Genomics, phytochemicals, and oxidative stress
- Retinal and Macular Surgery
- Chromatography in Natural Products
- Intraocular Surgery and Lenses
- Sesquiterpenes and Asteraceae Studies
- Moringa oleifera research and applications
- Bone health and osteoporosis research
- Phytochemicals and Antioxidant Activities
- Ocular Surface and Contact Lens
- Phytochemistry and biological activity of medicinal plants
- Reproductive System and Pregnancy
- Thermoregulation and physiological responses
- Retinal Imaging and Analysis
- Natural product bioactivities and synthesis
- NF-κB Signaling Pathways
- Natural Compound Pharmacology Studies
- Phytochemistry and Bioactive Compounds
- Luminescence Properties of Advanced Materials
- Glutathione Transferases and Polymorphisms
- Sinusitis and nasal conditions
- Lung Cancer Treatments and Mutations
Jiangxi Academy of Sciences
2021-2025
Shangqiu First People's Hospital
2013-2024
Anyang Eye Hospital
2021
Yunnan Agricultural University
2017-2020
Tea Research Institute
2017
Abstract Macrophages play an important role in the development of life-threatening sepsis, which is characterized by multiorgan dysfunction, through their ability to produce inflammatory cytokines. Carvacrol a phenolic compound that has been confirmed possess strong anti‑inflammatory activity. In this study, we mainly investigated effect carvacrol on lipopolysaccharide (LPS)-induced macrophage proinflammatory responses and endotoxic shock. The results showed significantly reduced mouse body...
Background and Objective: Tea drinking is associated with positive effects on bone health may protect against osteoporosis, especially in elderly women. Pu-erh tea has many beneficial human health; however, whether anti-osteoporotic potential remains unclear. Thus, we investigated the of extract (PTE) ovariectomy-induced osteoporosis rats osteoclastogenesis vitro. Methods: Female Wistar were divided into six groups: sham, model, Xian-Ling-Gu-Bao capsule (XLGB) groups, low-, medium-,...
Inflammation is generally considered a key risk factor in the progress of several chronic diseases, such as arthritis, gastritis, and hepatitis. Natural products with anti-inflammatory ability have played great role process overcoming these inflammatory diseases. In this study, we evaluated activities ten natural compounds derived from lotus seedpod discovered (E)-9-octadecenoic acid ethyl ester (E9OAEE) inhibited production nitric oxide (NO) optimally lipopolysaccharide (LPS)-induced...
Green tea (Camelliasinensis [L.] Kuntze) belongs to the plant family Theaceae and is mainly distributed in East Asia, Indian subcontinent Southeast Asia. This has been proven be beneficial human health, green second most consumed beverage world after water. However, until now, effect of aqueous extract (GTE) upon postmenopausal osteoporosis remained unclear. In this study, we investigated therapeutic effects GTE on estrogen deficiency-induced explored possible mechanisms vivo...
The chemical investigation of branches
Abstract BACKGROUND Moringa leaf is licensed as a new food ingredient and rich in nutrients. However, owing to its high cellulose content, the nutrients are difficult digest absorb, which limits product development application of leaf. RESULTS Four bacterial strains – Trichoderma reesei CICC 2626, Bacillus pumilus 10440, subtilis subsp . 21934, sp 21942 were chosen ferment with powder. The results solid fermentation liquid show that solid‐state using 10440 1:60 ratio powder produced greatest...
Etoposide is widely used in the chemotherapy of a variety malignancies. But strong lipophilicity, poor bioavailability, and severe side effects etoposide limit its clinical application. The aim this study was to develop sustained-release etoposide-loaded implants evaluate antitumor activity after intratumoral implantation. We prepared containing etoposide, poly(L-lactid acid) polyethylene glycol 4000 by direct compression method. were characterized regarding drug-excipient compatibility,...
Background: Macrophage plays an important role in innate immune responses by secreting molecules and phagocytosis. Camellia oleifera fruit shell, accounting for approximately 60% weight of the single C. oleifera fruit, is rich polysaccharides has several biological activities such as anti-oxidation, lipid regulation anticancer. However, immunomodulatory activity polysaccharide from C. shells (CPS) not been reported. Objective: This study aimed to...
Gynura procumbens is a traditional herb and food extensively cultivated in China Southeast Asian countries. This study was designed to determine the content of main chemical components elucidate antioxidant anti-inflammatory capacity G. flowers extracts (GPFE). GPFE rich flavonoids phenolics exhibited great reducing power as well strong scavenging ability ABTS+ DPPH radicals. The pro-inflammatory factors including IL-6, IL-1β, NO, TNF-α, PGE2 their mRNA transcriptions were strongly inhibited...
Abstract Background Epidermal growth factor receptor H773_V774 insH (EGFR‐insH) is an EGFR exon 20 insertion mutation in non‐small cell lung cancer (NSCLC), which naturally resistant to available tyrosine kinase inhibitors (TKIs) and lacks a patient‐derived line. Methods A Ba/F3 line expressing ‐insH (Ba/F3‐insH line) was generated using IL3‐deprivation method. proliferation assay performed screen natural compounds that exhibit synergistic effect with erlotinib. Trypan blue staining used...
<title>Abstract</title> Radiofrequency heating is widely used in medical aesthetics, which essentially achieves the contraction of collagen fibers dermis by increasing its temperature. The paper aimed to study selective and controllable mechanism for temperature field 0.02 kg ex-vivo pig skin samples obtained from 25 Bama under radiofrequency finite element method relevant experiments. A model was constructed at 4 MHz with a mixed mode fixed-point reciprocating sliding. Based on heating,...
Gout is the second largest metabolic disease worldwide after diabetes, with acute gouty arthritis as most common symptom. Xanthine oxidase (XOD) and NOD like receptor-3 (NLRP3) inflammasome are key targets for gout treatment. Chlorogenic acid has been reported a good anti-inflammatory activity, Apigenin showed an excellent potential in XOD inhibition. Therefore, series of chlorogenic acid-apigenin (CA) conjugates varying linkers were designed synthesized dual XOD/NLRP3 inhibitors, their...
Three new sesquiterpene lactones, including two eudesmanes, one germacrane-type, named borneolactones A-C (1-3), along with known analogue (4), were isolated from the ethyl acetate extract of branches and leaves Cinnamomum camphora chvar. Borneol. The planar structures absolute configurations compounds 1-3 unambiguously elucidated by comprehensive spectroscopic analysis, 1D, 2D NMR, HR−MS data, quantum electronic circular dichroic (ECD) calculations literature comparison. Compounds at 20 μM...
Objective: To evaluate intraoperative risk factors related to the postoperative visual acuity in idiopathic epiretinal membrane (IERM) . Methods: According well-established study criterion, a retrospective observational was carried out on 37 eyes of patients with peeling surgery for IERM between January 2014 and 2015. Intraoperative situations during were documented, including complexity operation, superficial hemorrhage state indocyanine green (ICG) staining. Best-corrected (BCVA)...
Gynura procumbens is a traditional herb and food extensively cultivated in China Southeast Asian countries. In this work, the crude extract (CE) of G. was purified with macroporous resin to obtain refined fraction, its anti-inflammatory activity compared that CE. Moreover, detailed mechanisms were also investigated for first time. The results indicated CE more effective it could reduce secretion NO, TNF-α, PGE2 via decreasing iNOS, COX-2 genes transcription related proteins translation,...