Abstract Corneal injury can lead to severe vision impairment or even blindness. Although numerous methods are developed accelerate corneal wound healing, most of them passive treatments that rarely participate in controlling endogenous cell behaviors incompatible with nontransparent bandage. In this work, a wireless‐powered electrical bandage contact lens (EBCL) is generate localized external electric field healing and recovery. The wireless stimulation circuit employed flower‐shaped layout...

Abstract This article reports and analyzes the results of protein complex model accuracy estimation by our methods (DeepUMQA3 GraphGPSM) in 15th Critical Assessment techniques for Structure Prediction (CASP15). The new deep learning‐based multimeric are proposed based on ensemble three‐level features coupling with residual/graph neural networks. For input model, we describe it from three levels: overall features, intra‐monomer inter‐monomer features. We designed an ultrafast shape...

<ns4:p>Identification of small and large molecule pain therapeutics that target the genetically validated voltage-gated sodium channel Na<ns4:sub>V</ns4:sub>1.7 is a challenging endeavor under vigorous pursuit. The monoclonal antibody SVmab1 was recently published to bind DII voltage sensor domain block human currents in heterologous cells. We produced purified protein based on publically available sequence information, evaluated its activity battery binding functional assays. Herein, we...

BRD9 and TAF1(2) have been regarded as significant targets of drug design for clinically treating acute myeloid leukemia, malignancies, inflammatory diseases. In this study, multiple short molecular dynamics simulations combined with the mechanics generalized Born surface area method were employed to investigate binding selectivity three ligands, 67B, 67C, 69G, BRD9/TAF1(2) IC50 values 230/59 nM, 1400/46 160/410 respectively. The computed free energies from MM-GBSA displayed good...

Model quality assessment is a crucial part of protein structure prediction and gateway to proper usage models in biomedical applications. Many methods have been proposed for assessing the structural monomers, but few evaluating complex models. As becomes new challenge, there an urgent need model that can accurately assess accuracy interface residues structures.Here, we present DeepUMQA3, web server structures using deep neural networks. For input structure, features are extracted from three...

An antihypertensive peptide, Lys-Val-Leu-Pro-Val-Pro (KVLPVP), can reduce blood pressure in hypertensive rats after being orally administered. In this study, the transepithelial transport of intact KVLPVP was examined by Caco-2 monolayers. The results were as follows: (i) flux not saturable for apical (AP) to basolateral (BL) or BL-AP when concentration 1–8 mm. (ii) Sodium deoxycholate loosened tight junction cells and significantly improved process. (iii) Phenylarsine oxide, a transcytotic...

The roots of Panax ginseng (ginseng) have been extensively used in traditional Chinese medicine. However, herb-drug interactions between and other co-administered drugs are not fully understood concerning the effect on drug metabolism clearance. current study aimed to elucidate total ginsenosides, a typical extract, regulation Cyp1a2, key enzyme regulate under normal inflammatory conditions mice. Female C57BL/6J mice treated with vehicle lipopolysaccharide (LPS) were intragastrically...

HMMer is a widely-used bioinformatics software package that uses profile Hidden Markov Models (HMMs) to model the primary structure consensus of family protein or nucleic acid sequences. However, with rapid growth both sequence and databases, it more time-consuming run on traditional computer architecture. With development modern field programmable gate array (FPGA) technology, applications can be accelerated using CPU-FPGA cooperative system by mapping computational-intensive work onto...

In this work, the influence of Ca addition on power loss MnZn ferrites was investigated. Mn–Zn were prepared by conventional oxide ceramic process from calcined powders different particle sizes in equilibrium sintering atmosphere. It has been found that optimal amount varies for synthesized using size.

This article reports and analyzes the results of protein complex model accuracy estimation by our methods (DeepUMQA3 GraphGPSM) in 15 Critical Assessment techniques for Structure Prediction (CASP15). The new deep learning-based multimeric are proposed based on ensemble three level features coupling with residual/graph neural networks. For input model, we describe it from levels: overall features, intra-monomer inter-monomer features. We designed an ultrafast shape recognition (USR) to...

Gout is the second largest metabolic disease worldwide after diabetes, with acute gouty arthritis as most common symptom. Xanthine oxidase (XOD) and NOD like receptor-3 (NLRP3) inflammasome are key targets for gout treatment. Chlorogenic acid has been reported a good anti-inflammatory activity, Apigenin showed an excellent potential in XOD inhibition. Therefore, series of chlorogenic acid-apigenin (CA) conjugates varying linkers were designed synthesized dual XOD/NLRP3 inhibitors, their...

Abstract With the breakthrough of AlphaFold2 on monomers, research focus structure prediction has shifted to protein complexes, driving continued development new methods for multimer prediction. Therefore, it is crucial accurately estimate quality scores model independent used methods. In this work, we propose a physical-aware deep learning method, DeepUMQA-PA, evaluate residue-wise complex models. For input model, residue-based contact area and orientation features were first constructed...

Abstract The scoring models used for protein structure modeling and ranking are mainly divided into unified field protein-specific functions. Although prediction has made tremendous progress since CASP14, the accuracy still cannot meet requirements to a certain extent. Especially, accurate of multi-domain orphan proteins remains challenge. Therefore, an efficient model should be developed urgently guide folding or through deep learning. In this work, we propose global based on equivariant...

Abstract Model quality assessment is a crucial part of protein structure prediction and gateway to proper usage models in biomedical applications. Many methods have been proposed for assessing the structural monomers, but few evaluating complex models. As becomes new challenge, model that can provide accurate evaluation structures are urgently required. Here, we present DeepUMQA3, web server using deep neural network. For an input structure, features extracted from three levels overall...

─ 83 【Objective】Perioperative oral nutritional supple mentation (ONS) is one of the main measures for Enhanced Recovery After Surgery (ERAS) .This study intends to discuss specific function ONS.【Methodology】20 patients in ONS group: 15 cases gastric cancer, 5 transverse colon can cer.40 non-ONS Gastric carci noma 29 cases, cancer 11 cases.Patients group only took enteral nu trients until 6 hours and water 2 be fore operation.No bowel preparation.Enteral trition tube was established...

Objective To explore the relation of gamma knife radiation doses and changes trigeminal nerves after irradiation by studying somatosensory evoked potentials (TSEP) characteristics nerve roots irradiated in normal animals. Methods Fifteen New Zealand rabbits were divided into 60 Gy group, 80 100 120 group control accordance with random number table (n=3). The first 4 groups used Gamma Plan 5.34 planning system to design targets doses. target was placed at root entry zone, bilateral...