A5100701126- Malaria Research and Control
- Insect Resistance and Genetics
- Mosquito-borne diseases and control
- Microbial Natural Products and Biosynthesis
- Iron Metabolism and Disorders
- Cytokine Signaling Pathways and Interactions
- Hemophilia Treatment and Research
- Heme Oxygenase-1 and Carbon Monoxide
- Hemoglobinopathies and Related Disorders
- Steroid Chemistry and Biochemistry
- Esophageal Cancer Research and Treatment
- Blood Coagulation and Thrombosis Mechanisms
- Extracellular vesicles in disease
- Synthesis and Biological Activity
- Bacterial Genetics and Biotechnology
- Metalloenzymes and iron-sulfur proteins
- Platelet Disorders and Treatments
- DNA Repair Mechanisms
- Erythropoietin and Anemia Treatment
- Pancreatic and Hepatic Oncology Research
- Cholinesterase and Neurodegenerative Diseases
- Ferroptosis and cancer prognosis
- Autophagy in Disease and Therapy
- Lung Cancer Treatments and Mutations
- Cancer Cells and Metastasis
Kobe Tokiwa University
2017-2024
Osaka Metropolitan University
2024
Kobe University
2021
Kyoto University
2014
Sendai Medical Center
2001
Yamaguchi University
1993-1995
Takeda (Japan)
1990
Takasago (United States)
1976
Takeda (United States)
1976
Abstract Background When the first systematic list of mosquitoes in Nepal was reported 1990, there no description Aedes aegypti (L.), while albopictus (Skuse) has been included Stegomyia subgroup since 1950s. The record Ae. 2009, suggesting some coincidence between invasion this species and dengue fever 2006. Results We performed a field survey distribution insecticide susceptibility 2017 2018. Mosquito larvae were collected from used tires located along streets Kathmandu, Bharatpur Pokhara,...
The Anopheles gambiae sensu lato species complex consists of a number cryptic with different habitats and behaviours. These morphologically indistinct are identified by chromosome banding. Several molecular diagnostic techniques for distinguishing between An. coluzzii still under improvement. Although, the current SINE method identification works reliably, this study describes refinement to increase sensitivity coluzzii, arabiensis based on amplicon dissociation curve characteristics....
SignificanceI explore hyperspectral imaging, a rapid and noninvasive technique with significant potential in biometrics medical diagnosis. Personal identification was performed using cross-sectional images of palms, offering simpler more robust method than conventional vascular pattern methods.AimI aim to demonstrate the local palm identify individuals high accuracy.ApproachHyperspectral imaging artificial intelligence (AI)-based region interest (ROI) detection, feature vector extraction,...
The main malaria vectors in sub-Saharan Africa, the Anopheles gambiae (Giles; Diptera: Culicidae), normally breed clean water sources. However, evidence suggests an on-going adaptation of Anopheline species to polluted breeding habitats urban settings. This study aimed at understanding bodies with different qualities, five selected mosquito sites Accra, Ghana. were also evaluated for WHO water-quality parameters as a measure pollution, and insecticide residues. Field mosquitoes genes;...
Xeroderma pigmentosum complementation group D (XPD) is a UV-sensitive syndrome and rare incurable genetic disease which caused by the mutation of excision repair cross-complementation 2 gene (ERCC2). Patients who harbor only XPD R683W mutant protein develop severe photosensitivity progressive neurological symptoms. Cultured cells derived from patients with (XPD cells) demonstrate reduced nucleotide (NER) ability. We hope to ameliorate clinical symptoms if we can identify candidate agents...
In transfusion-related iron overload, macrophage/reticuloendothelial cells are the first site of haem-derived accumulation. The prevention haem-induced cytotoxicity in macrophages may represent a target for overload treatment. Deferasirox, an oral chelator, has been used to treat however, low adherence therapy is issue. Statins, which widely atherosclerotic cardiovascular diseases, also have anti-oxidative and anti-inflammatory effects independent their lipid lowering ones. Whether statins...
The apoenzyme of yeast aconitase [EC 4.2.1.3] was prepared by treatment with sodium mersalyl, followed passage the reaction mixture through a column Dowex A-1 and gel filtration on Sephadex G-25. had no activity, but active enzyme could be reconstituted ferrous ions sulfide in presence 2-mercapto-ethanol. isolated DEAE-Sephadex A-50 chromatography G-100 from mixture. identical original untreated terms specific iron content spectral characteristics, not labile sulfur content. A significant...
Journal Article Modified dunking pancreatojejunostomy for a soft pancreas Get access Y Hamanaka, Hamanaka Second Department of Surgery, Yamaguchi University School Medicine, Yamaguchi, Japan Correspondence to: Dr I: 1144 Kogushi, Ube, 755, Search other works by this author on: Oxford Academic Google Scholar T Suzuki British Volume 82, Issue 3, March 1995, Pages 404–405, https://doi.org/10.1002/bjs.1800820342 Published: 07 December 2005 history Accepted: 25 July 1994
Abstract The Anopheles gambiae sensu lato species complex consists of a number cryptic with different habitats and behaviours. These morphologically indistinct are identified by chromosome banding molecular diagnostic techniques which still under improvement even though the current SINE method for identification between An. coluzzii works reliably. This study describes refinement to increase sensitivity high throughput both arabiensis using amplicon dissociation characteristics. Field...
我々は先に血友病B患者20例の凝固第IX因子(FIX)遺伝子を解析し,18種類の点変異を報告した(血栓止血誌15 : 107-113, 2004).その中で未報告のA28P,Q50KとL300Pと,新たに検出したP193Lの計4種類の組換え変異体を作成し,これらが血友病Bを引き起こす原因であることを,発現実験を用いて確認した.変異FIX遺伝子プラスミドをHEK293細胞にトランスフェクション後の培養上清のFIX活性と抗原量は,野生型100%に対して,A28Pが12%と58%,Q50Kが4%と77%,P193Lが1%と4%,L300Pが<1%と5%,であった.細胞溶解液の抗原量は同様に,A28Pが79%,Q50Kが67%,P193Lが92%で細胞内合成を認めたが,L300Pは20%と他と比較し減少していた.4種類の未報告変異は,実験結果と各々の血漿表現型とほぼ一致しており,病因変異と同定した.
A βaggregates through β-sheet formation to induce neurotoxicity in the pathogenesis of Alzheimer's disease (AD). In particular, oligomeric assemblies βcause cognitive dysfunction and synaptotoxicity. Given various sizes shapes oligomers (ADDL, β*56, amylospheroid, etc.), these are considered form two pathways (2 x n -mer 3 -mer) based on each dimer trimer unit. However, structural information is limited. Our previous research using solid-state NMR identified a toxic conformer β42 with turn...
<div>Abstract<p>Estrogens produced as a result of intratumoral aromatization has been recently shown to play important roles in proliferation human non–small cell lung carcinomas (NSCLC), but the details have remained largely unknown. Therefore, this study, we evaluated possible aromatase NSCLCs follows: (<i>a</i>) evaluation localization mRNA/protein six adenocarcinoma cases using laser capture microdissection combined with quantitative reverse transcriptase-PCR and...
ハイレスポンダーインヒビター保有血友病Aおよび血友病B患者に起きた3回の重症出血に対し, 凝固因子製剤の大量投与でインヒビターを中和し, 引き続き持続投与によって充分な血漿凝固因子活性を維持し, 止血に成功した. 症例1は第VIII因子インヒビター保有血友病A患者. 38歳時に小脳出血で緊急入院した. 2. 1ベセスダ単位(BU)/ml の第VIII因子インヒビターに対し, 第VIII因子製剤5, 000Uのボーラス投与に続き, 3. 8U/kg/hrの持続投与を行った. 血漿第VIII因子活性は4日間0. 9～1.44U/ml を維持し血腫は縮小した. 40歳時には, 外傷性頭頂葉皮質出血をきたし, バイパス療法を行ったが, 新たに右硬膜下血腫を認めたためインヒビター中和療法を施行した. 10BU/ml 第VIII因子製剤12, 4～6U/kg/hrの持続投与を行った. 血漿第VIII因子活性は, 5日間0.54～2.04U/ml 症例2は4歳の第IX因子インヒビター保有血友病B患者. 右足背部の打撲により大きな皮下血腫を生じた. 連日のバイパス療法でも改善せず,...