A5051922725- Viral gastroenteritis research and epidemiology
- Venomous Animal Envenomation and Studies
- Hepatitis Viruses Studies and Epidemiology
- PI3K/AKT/mTOR signaling in cancer
- Animal Virus Infections Studies
- Gestational Diabetes Research and Management
- Neurotransmitter Receptor Influence on Behavior
- Healthcare cost, quality, practices
- Iron Metabolism and Disorders
- Mycobacterium research and diagnosis
- Congenital Anomalies and Fetal Surgery
- vaccines and immunoinformatics approaches
- Signaling Pathways in Disease
- Tuberculosis Research and Epidemiology
- Cardiovascular, Neuropeptides, and Oxidative Stress Research
- Folate and B Vitamins Research
- Genetically Modified Organisms Research
- Eicosanoids and Hypertension Pharmacology
- Respiratory viral infections research
- bioluminescence and chemiluminescence research
- CRISPR and Genetic Engineering
- Health Systems, Economic Evaluations, Quality of Life
- Escherichia coli research studies
- Nitric Oxide and Endothelin Effects
- Healthcare and Venom Research
International Centre for Diarrhoeal Disease Research
2013-2025
Kanazawa University
2020
United States Department of Veterans Affairs
1991
University of Haripur
1979
Lewis and secretor histo–blood group antigens (HBGAs) have been associated with decreased susceptibility to P[8] genotype rotavirus (RV) infections. Efficacy of vaccines containing attenuated strains is in low-income countries. Host phenotype might impact vaccine efficacy (VE) by altering vaccination or RV diarrhea (RVD). We performed a substudy monovalent (RV1) trial Bangladesh determine the status on risk RVD VE. In infants randomized receive RV1 no at 10 17 weeks 1 year complete active...
Acetate relaxes rat caudal artery and increases tissue adenosine 3',5'-cyclic monophosphate (cAMP) levels. The present study's purpose was to determine whether related ultrashort chain (volatile) fatty acids, propionate (C3), butyrate (C4), octanoate (C8) would do so as well. It found that had very similar vasorelaxant profiles acetate; they relaxed strips precontracted with KCl, phenylephrine, arginine vasopressin, prostaglandin F2 alpha. vasorelaxation endothelium independent, not blocked...
Countries like Bangladesh face significant challenges in effectively registering and tracking deaths within their civil registration systems, which are essential for public health. To improve data collection health policy, death record-keeping at burial sites should be enhanced, particularly areas where certificates issued. With this mind, we examined the traditional paper-based practices recording deaths, perceived significance of these practices, associated challenges, expectations,...
Rotavirus (RV)-specific immunoglobulin A (IgA) responses following oral RV vaccination are impaired in low-income countries, where the utility of RV-IgA as a correlate protection (CoP) remains unclear. In monovalent vaccine (Rotarix) efficacy trial among infants Dhaka, Bangladesh, we identified factors associated with poor and explored CoP.Infants were randomized to receive Rotarix or no at 10 17 weeks life followed active diarrheal surveillance. concentration, seroconversion, seropositivity...
Environmental enteropathy (EE) is a poorly understood condition that refers to chronic alterations in intestinal permeability, absorption, and inflammation, which mainly affects young children resource-limited settings. Recently, EE has been linked suboptimal oral vaccine responses children, although immunological mechanisms are defined. The objective of this study was determine host factors associated with immune an cholera (OCV). We measured antibody memory T cell antigens, micronutrient...
Abstract Background Most patients starting chronic in-center hemodialysis (HD) receive conventional (CHD) with three sessions per week targeting specific biochemical clearance. Observational studies suggest that residual kidney function can safely be treated incremental prescriptions of HD, less frequent and later adjusting to thrice-weekly HD. This trial aims show objectively clinically matched HD (CMIHD) is non-inferior CHD in eligible patients. Methods An unblinded, parallel-group,...
Secretor status controls mucosal histo-blood group antigen expression and is associated with susceptibility to rotavirus (RV) diarrhea, nonsecretors less susceptible symptomatic infection. The role of breast milk secretor on oral live-attenuated RV vaccine response in breastfed infants has not been explored. In a monovalent G1P[8] (Rotarix) trial Bangladesh, RV-specific plasma immunoglobulin A antibody seroconversion rates were higher among maternal (39%) than secretors (23%; P = .001)....
Abstract Class II phosphatidylinositol 3-kinases (PI3K), PI3K-C2α and PI3K-C2β, are involved in cellular processes including endocytosis, cilia formation autophagy. However, the role of PI3K-C2β at organismal level is not well understood. We found that double knockout (KO) mice with both smooth muscle-specific KO global KO, but single either or exhibited reductions arterial blood pressure substantial attenuation contractile responses isolated aortic rings. In wild-type vascular muscle cells,...
Vitamin B12 deficiency is highly prevalent in Bangladesh and other countries with low animal source food intake. Poor status associated several adverse outcomes pregnancy infancy, breast milk B12; however no supplementation trials have been carried out pregnant women. In a pilot study, women (n=69, 18–35 y, Hb <115 g/L, 11–14 wk pregnant) were randomized to 250 ug B12/d or placebo through 4 mo postpartum. Both groups also received 400 folic acid + 60 mg Fe. Women immunized HINI vaccine at...
AbstractTwo recent studies reported that various poisons affecting the central nervous system do not elicit conditioned taste aversion (CTA). To test validity of this statement, cobra and krait neurotoxins were used as US in CTA paradigm compared with lithium chloride. The results indicate 10 7.5 μg venom 20, 15 produce clear-cut mice.
Rice-based vaccines do not require high-cost purification. They are stable at room temperature, can eliminate the risk of attenuated vaccine strains, and resistant to gastrointestinal degradation. We tested applicability an oral delivery system for tuberculosis (TB) cholera antigens in transgenic rice induction immune responses mucosal compartment as well systemic circulation. For development, we selected mycobacterial Ag85B antigen immunoprotective P4 epitope TcpA fused nontoxic toxin B...