A5090819625- Cancer Immunotherapy and Biomarkers
- CAR-T cell therapy research
- Endoplasmic Reticulum Stress and Disease
- Cancer Cells and Metastasis
- Immunotherapy and Immune Responses
- T-cell and B-cell Immunology
- Psoriasis: Treatment and Pathogenesis
- Dermatology and Skin Diseases
- Immune Cell Function and Interaction
- Cytokine Signaling Pathways and Interactions
- Reproductive tract infections research
- Reproductive System and Pregnancy
- PARP inhibition in cancer therapy
- Advanced Breast Cancer Therapies
- Calcium signaling and nucleotide metabolism
- Monoclonal and Polyclonal Antibodies Research
The University of Texas Health Science Center at San Antonio
2020-2025
The University of Texas Health Science Center at Houston
2023-2025
Central South University
2020
Abstract Background: Ovarian cancer (OCa) is the most lethal form of gynecologic in United States, with a five-year survival rate below 20%. Tumor resistance to chemotherapy and poor clinical outcomes are driven by intratumoral intertumoral heterogeneity. There critical need for novel therapies overcome these challenges. Recent findings indicate that elevated basal levels endoplasmic reticulum stress (ERS) OCa represent significant vulnerability identified LIPA as target inducing ERS cells...
Abstract Background: Ovarian cancer (OCa) is the deadliest kind of gynecologic in United States. The long-term survival rate for OCa less than 20% after five years. Intra-tumoral and inter-tumoral heterogeneity implicated tumor resistance to conventional therapies unsatisfactory clinical outcomes. Addressing these issues necessitates innovative that target intrinsic common vulnerabilities within OCa. Recent studies have highlighted high basal level endoplasmic reticulum stress (ERS) as a...
Abstract B effector cells produce Abs and autoantibodies, while regulatory use cytokines transmembrane proteins to fine tune immune functions. Our lab recently revealed that tumor-infiltrating IL-27 promote evasion, partly by upregulating tumoral PD-L1, including expressed per se. To investigate the autocrine activity of in tumor progression, we generated μMT:Il27ra–/– bone marrow chimera mice lacking receptor specifically cells. These displayed substantially reduced growth from...
Abstract B cells are exposed to innate and T cell stimuli during the antibody response, although whether how they functionally integrate such signals unclear. Here we have identified IL-27 as cytokine specifically produced by murine upon sequential stimulation TLR ligands then CD154 IL-21, hallmark factors of follicular helper cells, T-dependent response a conjugated hapten or virus infection. B-cell Il27p28 transcription is concomitant with increased locus accessibility depends on newly...
Abstract Background: Ovarian cancer (OCa) is the deadliest of all gynecologic cancers in United States. Despite initial response to chemotherapy, most OCa patients become chemo resistant and progress metastatic disease. Here, we tested hypothesis that high basal level endoplasmic reticulum stress (ERS) represents a critical vulnerability drugs further aggravate this already engaged system may exhaust its protective features contribute apoptosis induction. The objective proposal identify hit...
Intravaginal infection of mice with Chlamydia muridarum has been used for investigating the mechanisms trachomatis-induced pathogenicity and immune responses. In current study, mouse model was to evaluate impact interleukin-27 (IL-27) its receptor signaling on susceptibility female genital tract chlamydial infection. Mice deficient in IL-27 developed significantly shortened courses tract. The titers live recovered from IL-27-deficient declined by day 7 following intravaginal inoculation....
Abstract B cells promote tumor development in murine models of breast cancer (BCa), including - as we have shown by producing pleiotropic cytokine IL-27, which upregulates expression the PD-L1 immune checkpoint BCa and tumor-infiltrating (TIL-Bs). Paradoxically, cell activation has been to predict positive response inhibitors (ICIs) tumors melanoma, sarcoma kidney patients. Here, addressed role cell-expressed responses ICIs generating conditional knockout (KO) mice Cd274 (encoding PD-L1) was...
Abstract The discovery that PD-L1 inhibits PD-1 on CD8+ T cells has led to new mechanistic insights into the regulation of host immune responses. contribution expressed by different cell types remains poorly understood, partly due lack type-specific Cd274 (encoding PD-L1) knockout mice. Here, address role B cell-expressed in antibody response and tumor development, we have generated AicdacreCd274fl/fl mice, which was ablated only activated cells. As compared their wild-type littermates, mice...
Abstract B cells promote tumor development in murine models of breast cancer (BCa), including - as we have shown by producing pleiotropic cytokine IL-27, which upregulates expression the PD-L1 immune checkpoint BCa and tumor-infiltrating (TIL-Bs). Paradoxically, cell activation has been to predict positive response inhibitors (ICIs) tumors melanoma, sarcoma kidney patients. Here, addressed role cell-expressed responses ICIs generating conditional knockout (KO) mice Cd274 (encoding PD-L1) was...
Abstract B cells promote tumor development in murine models of breast cancer (BCa), – as we have shown by producing pleiotropic cytokine IL-27, which upregulates expression PD-L1 immune checkpoint BCa and tumor-infiltrating (TIL-Bs). Paradoxically, cell activation has been to predict a positive response inhibitors (ICIs) tumors melanoma, sarcoma kidney humans. Here, addressed the role cell-expressed responses ICIs generating conditional knockout mice Cd274 (encoding PD-L1) was ablated only...