A5046737384- Ion Channels and Receptors
- Ion channel regulation and function
- Neurobiology and Insect Physiology Research
- Pain Mechanisms and Treatments
- Neurofibromatosis and Schwannoma Cases
- Biochemical Analysis and Sensing Techniques
- Plant Stress Responses and Tolerance
- Herbal Medicine Research Studies
- Pancreatic function and diabetes
- Neuroscience and Neuropharmacology Research
- Neuroblastoma Research and Treatments
- Nicotinic Acetylcholine Receptors Study
- Infectious Diseases and Tuberculosis
- Cardiac electrophysiology and arrhythmias
- Receptor Mechanisms and Signaling
- Meningioma and schwannoma management
- Infectious Encephalopathies and Encephalitis
- Vascular Malformations Diagnosis and Treatment
- Urological Disorders and Treatments
- Coral and Marine Ecosystems Studies
- Calcium signaling and nucleotide metabolism
- Marine Sponges and Natural Products
- Postharvest Quality and Shelf Life Management
- Adrenal and Paraganglionic Tumors
- Diabetes Treatment and Management
Universidad Nacional Autónoma de México
2015-2024
Instituto Nacional de Cardiología
2018-2023
Sana Kliniken Duisburg
2015-2017
BG Klinikum Duisburg
2010-2015
University of Duisburg-Essen
2013
Klinikum Lüdenscheid
2006-2011
Instituto Politécnico Nacional
2011
Heinrich Heine University Düsseldorf
1993-2006
Düsseldorf University Hospital
2004-2006
University of Washington
2002-2004
TRPV1 ion channels mediate the response to painful heat, extracellular acidosis, and capsaicin, pungent extract from plants in Capsicum family (hot chili peppers) (Szallasi, A., P.M. Blumberg. 1999. Pharmacol. Rev. 51:159-212; Caterina, M.J., D. Julius. 2001. Annu. Neurosci. 24:487-517). The convergence of these stimuli on expressed peripheral sensory nerves underlies common perceptual experience pain due hot temperatures, tissue damage exposure capsaicin. are nonselective cation (Caterina,...
The TRPV1 ion channel serves as an integrator of noxious stimuli with its activation linked to pain and neurogenic inflammation. Cholesterol, a major component cell membranes, modifies the function several types channels. Here, using measurements capsaicin-activated currents in excised patches from TRPV1-expressing HEK cells, we show that enrichment cholesterol, but not diastereoisomer epicholesterol, markedly decreased wild-type rat currents. Substitutions S5 helix, rTRPV1-R579D,...
The Transient Receptor Potential Vanilloid 1 (TRPV1) ion channel is expressed in nociceptors where, when activated by chemical or thermal stimuli, it functions as an important transducer of painful and itch-related stimuli. Although the interaction TRPV1 with proteins that regulate its function has been previously explored, their modulation chaperones not elucidated, case for other mammalian TRP channels. Here we show physically interacts Sigma (Sig-1R), a chaperone binds progesterone,...
Background & AimsLimited understanding of pruritus mechanisms in cholestatic liver diseases hinders development antipruritic treatments. Previous studies implicated lysophosphatidic acid (LPA) as a potential mediator pruritus.MethodsPruritogenicity lysophosphatidylcholine (LPC), LPA's precursor, was examined naïve mice, and nonhuman primates. LPC's pruritogenicity involving keratinocyte TRPV4 studied using genetic pharmacologic approaches, cultured keratinocytes, ion channel physiology,...
The members of the superfamily Transient Receptor Potential (TRP) ion channels are physiologically important molecules that have been studied for many years and still being intensively researched. Among vanilloid TRP subfamily, TRPV4 channel is an interesting protein due to its involvement in several essential physiological processes development various diseases. As other proteins, changes function lead pathological states, closely associated with modification regulation by different...
The transient receptor potential vanilloid 1 (TRPV1) ion channel is mainly found in primary nociceptive afferents whose activity has been linked to pathophysiological conditions including pain, itch and inflammation. Consequently, it important identify naturally occurring antagonists of this channel. Here we show that a monounsaturated fatty acid, oleic inhibits TRPV1 activity, also pain responses mice by interacting with the (capsaicin)-binding pocket promoting stabilization closed state...
The Transient Receptor Potential Vanilloid 4 (TRPV4) channel has been shown to function in many physiological and pathophysiological processes. Despite abundant information on its importance physiology, very few endogenous agonists for this have described, underlying mechanisms activation clarified. TRPV4 is expressed by several types of cells, such as vascular endothelial, skin lung epithelial where it plays pivotal roles their function. In the present study, we show that activated...
Differentiation and function of pancreatic beta cells are regulated by a variety hormones growth factors, including nerve factor (NGF). Whether this is an endocrine or autocrine/paracrine role for NGF not known. We demonstrate that produced secreted adult rat cells. secretion increased in response to elevated glucose potassium, but decreased dibutyryl cAMP. Moreover, steady-state levels mRNA down-regulated cAMP, which opposite the effect cAMP on insulin release. NGF-stimulated changes...
Temperature-activated TRP channels or thermoTRPs are among the only proteins that can directly convert temperature changes into in channel open probability. In spite of a wealth functional and structural information, mechanism activation remains unknown. We have carefully characterized repeated TRPV1 by thermal stimuli discovered previously unknown inactivation process, which is irreversible. propose this form gating consequence heat absorption process leads to opening.
The functional properties of most sodium channels are too similar to permit identification specific channel types underlying macroscopic current. Such discrimination would be particularly advantageous in the nervous system which different family isoforms coexpressed same cell. To test whether members mu-conotoxin can discriminate among known neuronal types, we examined six toxins for their ability block heterologously expressed channels. PIIIA blocked rat brain type II/IIA (rBII/IIA) and...