Abstract This paper discusses the integration of artificial intelligence (AI) tools in education, delineating their potential to transform pedagogical practices alongside challenges they present. Generative AI models like ChatGPT, had a disruptive impact on teaching and learning, due ability create text, images, sound, revolutionizing educational content creation modification. However, nowadays community is polarized, with some embracing for its accessibility efficiency thus advocating it as...

Purpose: Ketosis is a metabolic state characterized by production of ketone bodies, including acetoacetate, β-hydroxybutyrate (BHB), and acetone, in response to reduced blood glucose levels. BHB stands out as the principal body nutritional ketosis which has diverse therapeutic implications for metabolic, nondegenerative neoplastic disorders. In current study we investigated impact on chronic myeloid leukaemia (CML) cell viability drug response. Materials Methods: We BHB-mediated K562 cells,...

Two amphiphilic star-hyperbranched copolymers with different hydrophilic PHEMA segments were synthesized, and their drug loading/release profiles examined by using Paclitaxel.

Ganoderma lucidum is a medicinal higher Basidiomycetes mushroom that exerts anticancer effects through several different mechanisms. This study investigated the of G. on telomerase activity and microRNA (miRNA) profiles MCF-7 cells. According to cytotoxicity results, ether extract exhibits highest cytotoxic potency; therefore it was chosen for subsequent assay miRNA profiling. The observed in cells treated with half-maximal inhibitory concentration (100 µg/mL dimethyl sulfoxide) 32.2% lower...

Lipogenesis is considered to be a very important aspect of cancer metabolism and targeting de novo lipid synthesis or related pathways are among novel approaches treat cancer. Many targets the pathway including ATP-citrate lyase (ACLY), acetyl-CoA carboxylase fatty acid synthase have been evaluated for their potential in treatment. However role citrate transport protein (CTP), another component lipogenesis pathway, not well known cell survival. Here we report that while chemical inhibition...

Olmesartan medoxomil (OM) is a hydrophobic antihypertensive drug with low bioavailability (26%) and known to have adverse effects such as celiac disease enteropathy. The purpose of this study was develop SMEDDS increase decrease potential side OM. Hydrophilic lipophilic balance calculated by testing solubility OM in different oils, surfactants, cosurfactants obtain the most suitable combination SMEDDS. Pseudoternary phase diagram used select better oil/water formulation After test for...

Calcitriol, the active form of vitamin D, is known for its anticancer properties including induction apoptosis as well inhibition angiogenesis and metastasis. Understanding mechanisms action calcitriol will help with development novel treatment strategies. Since D exerts cellular actions via binding to receptor by altering expressions a set genes, we aimed evaluate effect on transcriptomic profile breast cancer cells. We previously demonstrated that alters endoplasmic reticulum (ER) stress...

Reliability of preclinical research is critical concern. Prior studies have demonstrated the low reproducibility results and recommend implementing higher standards to improve overall quality robustness research. One understudied aspect this issue harmony between hypotheses experimental design in published work.In study we focused on highly cited cell culture investigated whether commonly asserted claims such as viability, cytotoxicity, proliferation rate, death apoptosis are backed with...

Calcitriol, the active form of vitamin D, is known for its anticancer properties including induction apoptosis, inhibition angiogenesis, and metastasis. Calcitriol also increases intracellular calcium triggering apoptosis in a calpain-dependent manner. Since main storage unit cellular endoplasmic reticulum (ER) decrease ER levels might induce stress associated cell death, we hypothesized that actions calcitriol occur via stress. We have evaluated by assessing BIP expression XBP-1 splicing...

Autophagy plays a critical role in maintaining cellular homeostasis and is implicated various physiological pathological processes, including cancer, neurodegeneration, metabolic disorders. Although typically associated with cell survival, autophagy has also been proposed to contribute death, referred as autophagic death (ACD). Despite its importance, the identification of ACD remains contentious due inconsistencies experimental methodologies terminological misuse. In this study, we...

Abstract Objectives Cancer cells modulate metabolic pathways to ensure continuity of energy, macromolecules and redox- homeostasis. Although these vulnerabilities are often targeted individually, targeting all with an enzyme may prove a novel approach. However, therapeutic enzymes prone proteolytic degradation neutralizing antibodies leading reduced half-life effectiveness. We hypothesized that glucose oxidase (GOX) catalyzes oxidation production hydrogen peroxide, hit targets by depleting...

Various games and activities of students can be used as an effective tool in the development mental capacities, skills intelligence games. Intelligence are that have all kinds problems, including real problems. So it is a good to teach problem solving. The course will enable develop capacity for perception assessment, create different perspectives, able make quick correct decisions when they encounter problem-solving habit, use reasoning logic effectively. Therefore, appropriate stepwise...

This study aims to evaluate the impact of STEM education on creative design skills trainee teachers. The sample for was made up third-year prospective teachers studying at Department Science Education and Elementary Mathematics in 2020-2021 school year. Embedded mixed design, which is a type method, used method while quantitative part comprised one-group pretest-posttest qualitative case study. implementation carried out creating lesson plans aimed activities process designs, obtaining...

Abstract Objectives Integration of the basic medical sciences with clinical medicine motivates students by showing how fundamental concepts they have learned will come into their future practice. In this context, we created integration sessions (CIS) in our first-year curriculum. Methods The instructors different disciplines wrote scenarios together. were discussed five 39 students. first session’s scenario consisted four brief “anemia” cases. next included a single case, according to...

Amaç: Oksidatif metabolizmanın in vitro fertilizasyon (IVF) üzerindeki rolü çok iyi araştırılmamıştır. Amacımız oksidatif stres belirteçlerinin müteakip oosit ve embriyo kalitesine etkisini incelemektir. Gereç Yöntemler: ICSI uygulanan 67 hastadan elde edilen toplam 214 folliküler sıvı değerlendirildi. Folliküler belirteç düzeyleri ile [Malondialdehit (MDA), nitrik oksit (NO) protein karbonil] takip eden kalitesi, morfolojileri arasındaki ilişki araştırıldı. Bulgular: Ortalama MDA seviyeleri...

Background/Purpose: The metabolic shift from catabolism of carbohydrates to lipids results in production ketone bodies leading a state called ketosis. Ketosis via supplement or ketogenic diet has been proposed as non-toxic therapeutic option for broad range malignancies. Although the clinical impact is well-documented, effect on cancer cell biology not clear some cancers including non-small-cell lung (NSCLC). In this study, we aimed demonstrate effects most prominent body, β-hydroxybutyrate,...