A5076636557- Functional Brain Connectivity Studies
- Neurotransmitter Receptor Influence on Behavior
- Schizophrenia research and treatment
- Receptor Mechanisms and Signaling
- Tryptophan and brain disorders
- Genetics and Neurodevelopmental Disorders
- Genetic Associations and Epidemiology
- Neuroscience and Neuropharmacology Research
- Neural and Behavioral Psychology Studies
- Epigenetics and DNA Methylation
- Autism Spectrum Disorder Research
- Bioinformatics and Genomic Networks
- Cannabis and Cannabinoid Research
- Mental Health and Psychiatry
- Nuclear Receptors and Signaling
- Amino Acid Enzymes and Metabolism
- Psychosomatic Disorders and Their Treatments
- Stress Responses and Cortisol
- Mental Health via Writing
- Attachment and Relationship Dynamics
- Nicotinic Acetylcholine Receptors Study
- Identity, Memory, and Therapy
- Orthopaedic implants and arthroplasty
- Music Therapy and Health
- Wnt/β-catenin signaling in development and cancer
University of Bari Aldo Moro
2013-2024
Azienda Universitaria Ospedaliera Consorziale - Policlinico Bari
2019-2024
Casa Sollievo della Sofferenza
2013
Personality traits related to emotion processing are, at least in part, heritable and genetically determined. Dopamine D 2 receptor signaling is involved modulation of emotional behavior activity associated brain regions such as the amygdala prefrontal cortex. An intronic single nucleotide polymorphism within gene ( DRD2 ) (rs1076560, guanine > thymine or G T) shifts splicing two protein isoforms (D short, mainly presynaptic, long) has been with memory performance activity. Here, our aim...
Both cannabis use and the dopamine receptor (DRD2) gene have been associated with schizophrenia, psychosis-like experiences, cognition. However, there are no published data investigating whether genetically determined variation in DRD2 dopaminergic signaling might play a role individual susceptibility to cannabis-associated psychosis. We genotyped (1) case-control study of 272 patients their first episode psychosis 234 controls, also from (2) sample 252 healthy subjects, for functional DRD2,...
Epigenetic mechanisms can mediate gene-environment interactions relevant for complex disorders. The BDNF gene is crucial development and brain plasticity, sensitive to environmental stressors, such as hypoxia, harbors the functional SNP rs6265 (Val66Met), which creates or abolishes a CpG dinucleotide DNA methylation. We found that methylation at Val allele in peripheral blood of healthy subjects associated with hypoxia-related early life events (hOCs) intermediate phenotypes schizophrenia...
OBJECTIVE Glycogen synthase kinase 3β (GSK-3β) is an enzyme implicated in neurodevelopmental processes with a broad range of substrates mediating several canonical signaling pathways the brain. The authors investigated association variation GSK-3β gene series progressively more complex phenotypes relevance to schizophrenia, disorder strong genetic risk. METHOD Based on computer predictions, humans functional 1) mRNA expression from postmortem prefrontal cortex, 2) and β-catenin protein...
The default mode network (DMN) comprises a set of brain regions with "increased" activity during rest relative to cognitive processing. Activity in the DMN is associated functional connections striatum and dopamine (DA) levels this region. A single-nucleotide polymorphism within D2 receptor gene (DRD2, rs1076560 G > T) shifts splicing 2 isoforms, short long, has been striatal DA signaling as well However, effects on have not explored. aim study was evaluate connectivity their relationship...
<h3>Importance</h3> Serotonin (5-hydroxytryptamine) receptor 2a (5-HT2AR) signaling is important for modulation of corticostriatal pathways and prefrontal activity during cognition. Furthermore, newer antipsychotic drugs target 5-HT2AR. A single-nucleotide polymorphism in the 5-HT2AR gene (<i>HTR2A</i>rs6314, C>T; OMIM 182135) has been weakly associated with differential physiologic as well behavioral effects. <h3>Objective</h3> To use a hierarchical approach to determine functional...
The GluN2B subunit of N-methyl-d-aspartate receptors is crucially involved in the physiology prefrontal cortex during working memory (WM). Consistently, genetic variants coding gene (GRIN2B) have been associated with cognitive phenotypes. However, it unclear how GRIN2B variation affects expression and processing. Using a composite score, we tested combined effect on activity WM performance healthy subjects.We computed score to combine effects single nucleotide polymorphisms post-mortem mRNA...
Cognitive dysfunction is central to the schizophrenia phenotype. Genetic and functional studies have implicated Disrupted-in-Schizophrenia 1 (DISC1), a leading candidate gene for related psychiatric conditions, in cognitive function. Altered expression of DISC1 DISC1-interactors has been identified schizophrenia. Dysregulated DISC1-interactome genes might, therefore, contribute susceptibility via disruption molecular systems required normal Here, blood RNA levels DISC1-interacting proteins...
"Schizotypy" is a latent organization of personality related to the genetic risk for schizophrenia. Some evidence suggests that schizophrenia and schizotypy share some biological features, including link dopaminergic D2 receptor signaling. A polymorphism in gene (DRD2 rs1076560, G>T) has been associated with short/long isoform expression ratio, as well striatal dopamine signaling prefrontal cortical activity during different cognitive operations, which are measures altered patients Here, our...
Multiple schizophrenia (SCZ) risk loci may be involved in gene co-regulation mechanisms, and analysis of coexpressed networks help to clarify SCZ molecular basis. We have previously identified a dopamine D2 receptor (DRD2) coexpression module enriched for genes associated with cognitive neuroimaging phenotypes SCZ, as well response treatment antipsychotics. Here we aimed identify regulatory factors modulating this their relevance SCZ. performed motif enrichment transcription factor (TF)...
Background Prefrontal behavior and activity in humans are heritable. Studies animals demonstrate an interaction between dopamine D2 receptors nicotinic acetylcholine on prefrontal but evidence is weak. Therefore, we hypothesize that genetic variation regulating receptor signaling impact cortex related cognition. To test this hypothesis humans, explored the functional variants gene (DRD2, rs1076560) α5 (CHRNA5, rs16969968) both dorsolateral mediated physiology during working memory gray...
The brain functional mechanisms translating genetic risk into emotional symptoms in schizophrenia (SCZ) may include abnormal integration between areas key for emotion processing, such as the amygdala and lateral prefrontal cortex (LPFC). Indeed, investigation of these is also complicated by processing comprising different subcomponents disease-associated state variables. Here, our aim was to investigate relationship SCZ effective connectivity LPFC during processing. Thus, we first...
Schizophrenia (SCZ) is a polygenic severe mental illness. Genome-wide association studies (GWAS) have detected genomic variants associated with this psychiatric disorder and pathway analyses indicated immune system dopamine signaling as core components of risk in dorsolateral-prefrontal cortex (DLPFC) hippocampus, but the mechanistic links remain unknown. The RasGRP1 gene, encoding for guanine nucleotide exchange factor, implicated response. has been identified candidate gene SCZ autoimmune...
Abstract Background Previous evidence suggests that early life complications (ELCs) interact with polygenic risk for schizophrenia (SCZ) in increasing the disease. However, no studies have investigated this interaction on neurobiological phenotypes. Among those, anomalous emotion-related brain activity has been reported SCZ, even if of its link SCZ-related genetic is not solid. Indeed, it possible relationship influenced by non-genetic factors. Thus, study between and ELCs activity. Methods...
Abstract "Compass" sentences or mantras can increase understanding of how cognitive processes apply in psychotherapy general. The Elementary Pragmatic Model may lead to the interpretation individual and relational particularly useful family therapy. model provides a procedure choose with strong psychological impact (SISCI-Sentences) through three presentations. These widen participants' horizons provide means functions according EPM. be used target structured unstructured interventions, as...
Genome-Wide Association Studies (GWASs) have identified several genes associated with Schizophrenia (SCZ) and exponentially increased knowledge on the genetic basis of disease. In addition, products GWAS interact neuronal factors coded by lacking association, such that this interaction may confer risk for specific phenotypes brain disorder. regard, fragile X mental retardation syndrome-related 1 (FXR1) gene has been SCZ. FXR1 protein is regulated glycogen synthase kinase-3β (GSK3β), which...