Ileana Andriola
A5007109732- Schizophrenia research and treatment
- Functional Brain Connectivity Studies
- Treatment of Major Depression
- Tryptophan and brain disorders
- Bipolar Disorder and Treatment
- Mental Health Research Topics
- Neuroscience and Music Perception
- Advanced Neuroimaging Techniques and Applications
- Mental Health Treatment and Access
- Neural dynamics and brain function
- Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Genetics and Neurodevelopmental Disorders
- Maternal Mental Health During Pregnancy and Postpartum
- Neurotransmitter Receptor Influence on Behavior
- Family Caregiving in Mental Illness
- Child and Adolescent Psychosocial and Emotional Development
- Genomics and Rare Diseases
- Congenital heart defects research
- Multiple Sclerosis Research Studies
- Neuroscience and Neuropharmacology Research
- Genomic variations and chromosomal abnormalities
- Neural Networks and Applications
- Nuclear Receptors and Signaling
- Early Childhood Education and Development
- Attention Deficit Hyperactivity Disorder
University of Bari Aldo Moro
2013-2025
Azienda Universitaria Ospedaliera Consorziale - Policlinico Bari
2021-2024
University of Pisa
2023
University of Genoa
2023
University of Rome Tor Vergata
2023
The Sense Innovation and Research Center
2023
University of Campania "Luigi Vanvitelli"
2023
Authorised Association Consortium
2022
Bipolar depression accounts for most of the disease duration in type I and II bipolar disorder (BD), with few treatment options, often poorly tolerated. Many individuals do not respond to first-line therapeutic resulting treatment-resistant (B-TRD). Esketamine, S-enantiomer ketamine, has recently been approved (TRD), but no data are available on its use B-TRD.To compare efficacy esketamine two samples unipolar TRD, providing preliminary indications effectiveness B-TRD. Secondary outcomes...
Esketamine, the S-enantiomer of ketamine, has recently emerged as a therapy for treatment-resistant depression (TRD), showing both rapid antidepressant action and good efficacy high safety. It is also indicated acute short-term treatment psychiatric emergency due to major depressive disorder (MDD) symptoms in adults with MDD suicidal thoughts/behavior. We here provide preliminary insights on esketamine nasal spray (ESK-NS) effectiveness safety among patients substance use (SUD) within sample...
Treatment-resistant depression (TRD) represents a severe clinical condition with high social and economic costs. Esketamine Nasal Spray (ESK-NS) has recently been approved for TRD by EMA FDA, but data about predictors of response are still lacking. Thus, tool that can predict the individual patients' probability to ESK-NS is needed. This study investigates sociodemographic features predicting responses in patients using machine learning techniques. In retrospective, multicentric, real-world...
IntroductionTreatment-resistant depression (TRD) is a serious and debilitating psychiatric disorder that frequently affects older patients. Esketamine nasal spray (ESK-NS) has recently been approved as treatment for TRD, with multiple studies establishing its efficacy tolerability. However, the real-world effectiveness, tolerability, safety of this in adults still unclear.ObjectivesTo evaluate tolerability ESK-NS subjects TRD.MethodsThis post-hoc analysis REAL-ESK study, multicenter,...
Objective The study aimed to explore premorbid academic and social functioning in patients with schizophrenia, its associations the severity of negative symptoms neurocognitive impairment. Method Premorbid adjustment ( PA ) schizophrenia was compared early unaffected first‐degree relatives healthy controls. Its psychopathology, cognition, real‐life were investigated. primary their two factors explored. Results We found an impairment P ≤ 0.000001) aspects 0.01). Patients poor showed greater...
Abstract Background Treatment-resistant depression (TRD) is defined by the European Medicines Agency as a lack of clinically meaningful improvement after treatment, with at least two different antidepressants. Individual, familiar, and socio-economic burden TRD huge. Given clear guidelines, large variability approaches across countries availability new medications to meet need effective rapid acting therapeutic strategies, it important understand consensus regarding clinical characteristics...
<h3>Importance</h3> Serotonin (5-hydroxytryptamine) receptor 2a (5-HT2AR) signaling is important for modulation of corticostriatal pathways and prefrontal activity during cognition. Furthermore, newer antipsychotic drugs target 5-HT2AR. A single-nucleotide polymorphism in the 5-HT2AR gene (<i>HTR2A</i>rs6314, C>T; OMIM 182135) has been weakly associated with differential physiologic as well behavioral effects. <h3>Objective</h3> To use a hierarchical approach to determine functional...
Background. Treatment-resistant depression (TRD) is a prevalent, high-burden disorder. Esketamine nasal spray (ESK-NS) has been approved for, T.R.D.; and efficacy observed in both clinical trials real-world studies. However, observations integrating patients’ perspective on this treatment are limited. This multicentric Italian study explored experiences with ESK-NS TRD patients, focusing perceived therapeutic effects overall satisfaction. Methods. A self-report survey was administered to 236...
The GluN2B subunit of N-methyl-d-aspartate receptors is crucially involved in the physiology prefrontal cortex during working memory (WM). Consistently, genetic variants coding gene (GRIN2B) have been associated with cognitive phenotypes. However, it unclear how GRIN2B variation affects expression and processing. Using a composite score, we tested combined effect on activity WM performance healthy subjects.We computed score to combine effects single nucleotide polymorphisms post-mortem mRNA...
Our manuscript aims to: 1) assess physical health in a sample of patients with severe mental disorders; and 2) identify the psychopathological psychosocial characteristics associated an increased likelihood having poor health. The study, funded by Italian Ministry Education, has been carried out psychiatric outpatient units six University sites. All recruited have assessed through standardized assessment instruments. Moreover, anthropometric parameters obtained at recruitment blood samples...
Abstract A consensus has not yet been reached regarding the accuracy of people with schizophrenia in self-reporting their real-life functioning. In a large ( n = 618) cohort stable, community-dwelling patients we sought to: (1) examine concordance patients’ reports functioning key caregiver; (2) identify which patient characteristics are associated to differences between and informants. Patient-caregiver ratings three Specific Level Functioning Scale (SLOF) domains (interpersonal...
Abstract Background Deficits in social cognition (SC) are significantly related to community functioning schizophrenia (SZ). Few studies investigated longitudinal changes SC and its impact on recovery. In the present study, we aimed: (a) estimate magnitude clinical significance of change outpatients with stable SZ who were assessed at baseline after 4 years, (b) identify predictors reliable clinically significant (RCSC), (c) determine whether over years predicted patient recovery follow-up....
Abstract Background People with severe mental illnesses (SMI) have a mortality rate two times higher compared to the general population, decade of years life lost. In this randomized controlled trial (RCT), we assessed in sample people bipolar disorder, major depressive and schizophrenia spectrum efficacy an innovative psychosocial group intervention brief psychoeducational on patients’ body mass index (BMI), weight, waist circumference, Framingham HOMA-IR indexes. Methods This is...
Abstract Background Recent views posited that negative parenting and attachment insecurity can be considered as general environmental factors of vulnerability for psychosis, specifically individuals diagnosed with psychosis (PSY). Furthermore, evidence highlighted a tight relationship between style social cognition abilities, key PSY behavioral phenotype. The aim this study is to generate machine learning algorithm based on the perceived quality style-related features discriminate healthy...
Cognition and social cognition anomalies in patients with bipolar disorder (BD) schizophrenia (SCZ) have been largely documented, but the degree of overlap between two disorders remains unclear this regard. We used machine learning to generate combine classifiers based on cognitive socio-cognitive variables, thus delivering unimodal multimodal signatures aimed at discriminating BD SCZ from independent groups Healthy Controls (HC1 HC2 respectively). Multimodal discriminated well controls both...
Abnormalities in hippocampal-parahippocampal (H-PH) function are prominent features of schizophrenia and have been associated with deficits episodic memory. However, it remains unclear whether these abnormalities represent a phenotype related to genetic risk for or they disease state.We investigated H-PH-mediated behavior physiology, using blood oxygenation level-dependent functional magnetic resonance imaging (BOLD fMRI), during memory sample patients schizophrenia, clinically unaffected...
Abstract This multicentric randomized controlled trial (RCT), carried out in six Italian University mental health sites, aims to test the efficacy of a six-month psychosocial intervention (LYFESTYLE) on Body Mass Index (BMI), body weight, waist circumference, fasting glucose, triglycerides, cholesterol, Framingham and HOmeostasis Model Assessment insulin resistance (HOMA-IR) indexes patients with schizophrenia, bipolar disorder, major depression. Moreover, has also been tested several other...
Variants appearing de novo in genes regulating key neurodevelopmental processes and/or non-coding cis-regulatory elements (CREs), as enhancers, may increase the risk for schizophrenia. However, CREs involvement schizophrenia needs to be explored more deeply.We investigated copy-number variations (CNVs) whole-genomic DNA obtained from 46 family trios of probands by using Enhancer Chip, a customised array CGH able investigate whole genome with 300-kb resolution, specific disease loci at...
Data on long-term treatment with Esketamine Nasal Spray (ESKNS) in real-world patients resistant depression (TRD) is scarce. The primary aim of the study to evaluate effectiveness and tolerability ESK-NS at 6 12-month follow-ups. This part an observational, retrospective, multicentric Italian (REAL-ESK study). Subjects for present underwent psychiatric assessments after 12 months from start treatment. Repeated measures analysis variance (ANOVA) was used assess changes continuous variables,...