A5086799420- Plant Molecular Biology Research
- Plant Gene Expression Analysis
- Plant tissue culture and regeneration
- Light effects on plants
- RNA modifications and cancer
- Genomics and Chromatin Dynamics
- Plant and Fungal Interactions Research
- Cancer-related molecular mechanisms research
- RNA Research and Splicing
- Plant responses to water stress
- Studies on Chitinases and Chitosanases
- Peptidase Inhibition and Analysis
- Plant nutrient uptake and metabolism
University of California, Los Angeles
2023-2025
National Taiwan University
2020-2024
Abstract Arabidopsis (Arabidopsis thaliana) FLOWERING LOCUS C (FLC) acts as a key flowering regulator by repressing the expression of floral integrator T (FT). Prolonged exposure to cold (vernalization) induces reducing FLC expression. The long noncoding RNAs (lncRNAs) COOLAIR and COLDAIR, which are transcribed from 3′ end first intron FLC, respectively, important for repression under vernalization. However, molecular mechanism how COLDAIR transcriptionally activated remains elusive. In this...
Arabidopsis telomeric repeat binding factors (TRBs) can bind DNA sequences to protect telomeres from degradation. TRBs also recruit Polycomb Repressive Complex 2 (PRC2) deposit tri-methylation of H3 lysine 27 (H3K27me3) over certain target loci. Here, we demonstrate that associate and colocalize with JUMONJI14 (JMJ14) trigger H3K4me3 demethylation at some The trb1/2/3 triple mutant the jmj14-1 show an increased level TRB JMJ14 sites, resulting in up-regulation their genes. Furthermore,...
DNA methylation plays crucial roles in gene regulation and transposon silencing. In plants, the maintenance of is controlled by several self-reinforcing loops involving histone non-coding RNAs. However, how initially patterned at specific loci unknown. Here, we describe four Arabidopsis REM transcription factors, VDD, VAL, REM12 REM13, that recognize sequence regions, together with protein GENETICS DETERMINES EPIGENETICS1 (GDE1), recruit RNA polymerase IV complexes to generate 24-nucleotide...
Arabidopsis thaliana CONSTANS (CO) is an essential transcription factor that promotes flowering by activating the expression of floral integrator FLOWERING LOCUS T (FT). A number histone modification enzymes involved in regulation have been identified, but involvement epigenetic mechanisms core regulator CO remains unclear. Previous studies indicated factors, BHLH1 (FBH1), FBH2, FBH3, and FBH4, function redundantly to activate CO. In this study, we found KDM3 group H3K9 demethylase JMJ28...
The Arabidopsis H3K9 methyltransferases KRYPTONITE/SUPPRESSOR OF VARIEGATION 3-9 HOMOLOG 4 (KYP/SUVH4), SUVH5 and SUVH6 are redundantly involved in silencing of transposable elements (TEs). Our recent study indicated that KYP/SUVH5/6 can directly interact with the histone deacetylase HDA6 to synergistically regulate TE expression. However, function plant development is still unclear. transcriptional factors ASYMMETRIC LEAVES1 (AS1) AS2 form a transcription complex, which leaf by repressing...
Eukaryotic histone deacetylation, critical for maintaining nucleosome structure and regulating gene expression, is mediated by deacetylases (HDACs). Although nucleosomes have been reported to regulate mRNA polyadenylation in humans, the role of HDACs has not uncovered. Taking advantage phenotypic studies on Arabidopsis, HDA6 (one HDACs) was found be a part many biological processes. Here, we report that affects Arabidopsis Poly(A) sites up-regulated transcripts are closer acetylation peaks...
Abstract In recent years, eukaryotic long non-coding RNAs (lncRNAs) have been identified as important factors involved in a wide variety of biological processes, including histone modification, alternative splicing and transcription enhancement. The expression lncRNAs is highly tissue-specific regulated by environmental stresses. Recently, large number plant identified, but very few them studied detail. Furthermore, the mechanism lncRNA regulation remains largely unknown. Arabidopsis HISTONE...
Abstract Arabidopsis telomeric repeat binding factors (TRBs) can bind DNA sequences to protect telomeres from degradation. TRBs also recruit Polycomb Repressive Complex 2 (PRC2) deposit tri-methylation of H3 lysine 27 (H3K27me3) over certain target loci. Here, we demonstrate that associate and colocalize with JUMONJI14 (JMJ14) trigger H3K4me3 demethylation at some The trb1/2/3 triple mutant the jmj14-1 show an increased level TRB JMJ14 sites, resulting in up-regulation their genes....
Abstract Arabidopsis KRYPTONITE/SUPPRESSOR OF VARIEGATION 3–9 HOMOLOG 4 (KYP/SUVH4), SUVH5 and SUVH6 are H3K9 methyltransferases they redundantly involved in silencing of transposable elements (TEs). A recent study indicated that KYP/SUVH5/6 can directly interact with the histone deacetylase HDA6 to synergistically regulate TE expression. However, function plant development is still unclear. The ASYMMETRIC LEAVES1 (AS1) AS2 form a transcription complex, which leaf by repressing homeobox...