A5003415027- Burn Injury Management and Outcomes
- Traumatic Ocular and Foreign Body Injuries
- Cancer, Hypoxia, and Metabolism
- Wound Healing and Treatments
- Cancer Immunotherapy and Biomarkers
- Restraint-Related Deaths
- Heme Oxygenase-1 and Carbon Monoxide
- Cancer-related molecular mechanisms research
- Reconstructive Surgery and Microvascular Techniques
- Angiogenesis and VEGF in Cancer
- MicroRNA in disease regulation
- Immunotherapy and Immune Responses
- Nitric Oxide and Endothelin Effects
- Ferroptosis and cancer prognosis
- Cancer, Lipids, and Metabolism
- Advanced Decision-Making Techniques
- Extracellular vesicles in disease
- Combustion and Detonation Processes
- Single-cell and spatial transcriptomics
- Risk and Safety Analysis
- Automotive and Human Injury Biomechanics
- Medical Research and Treatments
- Barrier Structure and Function Studies
- Plant and Fungal Interactions Research
- Autophagy in Disease and Therapy
First Affiliated Hospital of Anhui Medical University
2002-2023
Anhui Medical University
2002-2023
Shenzhen University
2009
Global patterns of immune cell communications in the microenvironment skin cutaneous melanoma (SKCM) haven't been well understood. Here we recognized signaling roles populations and main contributive signals. We explored how multiple cells signal paths coordinate with each other established a prognosis signature based on key specific biomarkers cellular communication.The single-cell RNA sequencing (scRNA-seq) dataset was downloaded from Gene Expression Omnibus (GEO) database, which various...
microRNA is a small non-coding RNA molecule and functions in silencing post-transcriptional regulation of gene expression. This study was designed to evaluate the role miR-98 development microvascular permeability its molecular pathogenesis.Forty-eight healthy adult Wistar rats were divided into control group (n = 8) burn 40) that inflicted with 30% total body surface area third-degree burn. Groups processed at 2, 4, 8, 12, 24 h post-burn. Plasma for vascular endothelial cell culture...
Abstract The mechanism underlying burn injury-induced enhanced vascular endothelial permeability and consequent body fluid extravasation is unclear. Here, the rat aortic cells (RAECs) were treated with serum derived from rats injury to elucidate mechanism. Sprague–Dawley (SD) grouped as follows (10 rats/group): control, 2, 4, 8, 12, 24 hours postburn groups. heart, liver, kidney, lung, jejunum, ileum of injected 2% Evans blue (EB) through tail vein excised detect EB level in each organ....
Skin cutaneous melanoma (SKCM) attracts attention worldwide for its extremely high malignancy. A novel term cytolytic activity (CYT) has been introduced as a potential immunotherapy biomarker associated with counter-regulatory immune responses and enhanced prognosis in tumors. In this study, we extracted all datasets of SKCM patients, namely, RNA sequencing data clinical information from The Cancer Genome Atlas (TCGA) database the Gene Expression Omnibus (GEO) database, conducted...
Abstract Background Local tissue damage caused by electrical burns is often deep and severe. High-voltage are common in the head, neck torso areas. These mostly direct contact with power supply accompanied injuries of nerve, blood vessel, muscle, tendon, bone. We must pay great attention to clinical treatment these parts injured burn. Case presentation The first case involved a migrant worker who touched 6-kV high-tension wire when welding steel; this electric shock many places. Deep burn...
Objective: To analyze the reasons for failure of Meek micro-skin grafting in children with severe burns and to observe clinical effects treatment measures. Methods: Thirty hospitalized First Affiliated Hospital Anhui Medical University (hereinafter referred as author's affiliation) from January 2012 2018, conforming inclusion criteria were included failed skin graft group. Children group performed operation failed, including 17 males 13 females aged 1 12 year(s). affiliation during same...
Objective: To investigate the regulation of hypoxia-inducible factor-1α (HIF-1α) on permeability rat vascular endothelial cells and mechanism. Methods: Twelve male Sprague-Dawley rats aged 35 to 38 days were collected separated cultured. The morphology was observed after 4 culture, following experiments performed 2nd or 3rd passage cells. (1) Rat divided into blank control group, negative HIF-1α interference sequence 1 2 3 group according random number table (the same grouping method below),...
Abstract Background and aims Evidence has shown that miR-31 is a molecule associated with inflammation in different types of cells.However,the changes LPS-stimulated endothelial cells the effect this change expression on are unknown.This study sought to investigate how modulates permeability culture pulmonary microvascular (PMVECs). Methods It was discovered enhanced cell monolayer defined by lower TER higher FITC-dextran levels. Cell viability evaluated using an MTT assay, inflammatory...
Abstract CO poisoning is the most common cause of injuries and deaths after worldwide. Exposed charcoals furnaces are often used for heating in parts world. When occurs a coma, people may faint on burning charcoal furnace, suffer severe burns. This article reports two cases burns caused by poisoning, first patient even required amputation his left leg. Besides, long painful treatments irreversible changes appearance function have brought huge economic pressure serious psychological barriers...