A5005050970- Mesenchymal stem cell research
- Reproductive System and Pregnancy
- Pluripotent Stem Cells Research
- Renal and related cancers
- Renal Diseases and Glomerulopathies
- CAR-T cell therapy research
- Wound Healing and Treatments
- Virus-based gene therapy research
- Neuroscience and Neural Engineering
- Ferroptosis and cancer prognosis
- Oral and gingival health research
- Tissue Engineering and Regenerative Medicine
- Cancer Diagnosis and Treatment
- Renal cell carcinoma treatment
- Cancer Cells and Metastasis
- AI in cancer detection
- 3D Printing in Biomedical Research
- HIV-related health complications and treatments
- CRISPR and Genetic Engineering
- Endometriosis Research and Treatment
- Reconstructive Surgery and Microvascular Techniques
- Biomarkers in Disease Mechanisms
- HIV Research and Treatment
- Cancer Immunotherapy and Biomarkers
- Bone and Joint Diseases
Universidad Nacional de La Plata
2020-2025
Consejo Nacional de Investigaciones Científicas y Técnicas
2021-2025
Fundación para la Lucha contra las Enfermedades Neurológicas de la Infancia
2021-2024
University of Carabobo
2013
Pulmonary and extrapulmonary manifestations have been reported following infection with SARS-CoV-2, the causative agent of COVID-19. The virus persists in multiple organs due to its tropism for various tissues, including skeletal system. This study investigates effects SARS-CoV-2 infection, both ancestral Omicron viral strains, on differentiating mesenchymal stem cells (MSCs), precursor cells, into osteoblasts. Although strains can productively infect osteoblasts, cell remained abortive....
Abstract Background Clear cell renal carcinoma (ccRCC), the most aggressive cancer, is characterized by early lymph node metastases and bad prognosis. Most therapies targeting advanced or metastatic ccRCC are based, as first-line treatment, on administration of vascular endothelial growth factor (VEGF) neutralizing antibody termed Bevacizumab. Despite proven benefits, expected results were not obtained for majority patients. The possibility that an intricate interplay between angiogenesis...
Wound healing after skin injury is a complex process, particularly in equines where leg wounds are prevalent and their repair complicated due to the anatomical characteristics. Conventional treatments not effective enough. The umbilical cord offers an unlimited source of adult mesenchymal stem cells (ucMSCs) from Wharton's jelly tissue. present study aims demonstrate safety therapeutic potential allogeneic use equine ucMSCs (e-ucMSCs) severe wounds. methods employed were isolation, culture...
In the mouse embryo, transition from preimplantation to postimplantation epiblast is governed by changes in gene regulatory network (GRN) that lead transcriptional, epigenetic, and functional changes. This can be faithfully recapitulated vitro differentiation of embryonic stem cells (mESCs) epiblast-like (EpiLCs), reside naïve formative states pluripotency, respectively. However, GRN drives this conversion not fully elucidated. Here we demonstrate transcription factor OCT6 a key driver...
In normal physiological conditions, restoration of a functional epidermal barrier is highly efficient; nevertheless, when it fails, one the main consequences chronic ulcerative skin defect, most frequently recognized complications diabetes. Most these venous ulcers do not heal with conventional treatment, leading to appearance infections and in patient. Treatments based on use autologous mesenchymal stem cells (MSC) have been successful; however, its implementation entails complications. The...
Cancer immunotherapies based mainly on the blockade of immune-checkpoint (IC) molecules by anti-IC antibodies offer new alternatives for treatment in oncological diseases. However, a considerable proportion patients remain unresponsive to them. Hence, development novel clinical immunotherapeutic approaches and/or targets are crucial.W In this context, targeting HLA-G/ILT2/ILT4 has caused great interest since it is abnormally expressed several malignancies generating tolerogenic...
Feature selection is a process used in the automatic learning that consists selecting an optimal subset of features database to reduce its dimensionality, remove noise and improve performance algorithm. That is, speed, precision prediction (measured by hit rate) comprehensibility results obtained. The aim this paper apply such techniques dimensionality reduction on processed image extracted through textural analysis. images were obtained colposcope as part routine gynaecological...
Bone loss is a prevalent characteristic among people with HIV (PWH). We focused on mesenchymal stem cells (MSCs) and osteoblasts, examining their susceptibility to different strains (R5- X4-tropic) the subsequent effects bone tissue homeostasis. Our findings suggest that MSCs osteoblasts are susceptible R5- X4-tropic but do not support productive replication. exposure during osteoblast differentiation process revealed virus could alter mineral organic matrix deposition. However, reduction in...
Abstract Animal development relies on complex gene regulatory networks (GRNs) that govern the nearly irreversible changes occur during cell differentiation. In this work we aimed to determine key transcription factors (TFs) associated with dissolution of naïve pluripotent state and acquisition a formative identity. We identified OCT6 as one earliest TFs induced onset mouse embryonic stem (mESCs) To investigate its role, generated an Oct6 knockout mESC line, which failed acquire...
Abstract Cancer immunotherapies based mainly on the blockade of immune-checkpoint (IC) molecules by anti-IC antibodies offer new alternatives for treatment in oncological diseases. However, a considerable proportion patients remain unresponsive to them. Hence, development novel clinical immunotherapeutic approaches and/or targets are crucial. In this context, targeting HLA-G/ILT2/ILT4 has caused great interest since it is abnormally expressed several malignancies generating tolerogenic...