A5038700525- Synthesis and biological activity
- Enzyme function and inhibition
- Synthesis and Characterization of Heterocyclic Compounds
- Computational Drug Discovery Methods
- Enzyme Catalysis and Immobilization
- Phenothiazines and Benzothiazines Synthesis and Activities
- Cholinesterase and Neurodegenerative Diseases
- Metal complexes synthesis and properties
- Cell death mechanisms and regulation
- Cancer therapeutics and mechanisms
- Synthesis of heterocyclic compounds
- Microbial Metabolic Engineering and Bioproduction
- Synthesis and Catalytic Reactions
- Phytochemistry and Biological Activities
- Crystallization and Solubility Studies
- Natural Antidiabetic Agents Studies
- Histone Deacetylase Inhibitors Research
- Monoclonal and Polyclonal Antibodies Research
- Free Radicals and Antioxidants
- Synthesis of Organic Compounds
- Adsorption and biosorption for pollutant removal
- X-ray Diffraction in Crystallography
- Analytical Chemistry and Chromatography
- Nanomaterials for catalytic reactions
- Diet, Metabolism, and Disease
European University Cyprus
2023-2025
European University of Lefke
2020-2025
Istanbul University
2017-2023
Fatih University
2023
Abstract In this project, non‐sulfonamide bistrifluoromethyl‐derived hydrazide‐hydrazones were synthesized as multi‐target‐directed ligands to treat Alzheimer's disease and then, the novel derivatives characterized by diverse spectral methods. Acetylcholinesterase (AChE), human carbonic anhydrase (hCA) inhibitory qualifications of these compounds determined. The reported ( 2a ‐ y ) determined be effective inhibitors hCA I, II AChE enzymes with K i values in range 1.130 ± 0.15–5.440 0.93 μM...
Background: Despite recent breakthroughs in cancer treatment, non-small cell lung (NSCLC) and breast remain major causes of death from all malignancies. The epidermal growth factor receptor (EGFR) is an important mediator the pathways involved proliferation, apoptosis, angiogenesis. Thus, its overexpression triggers several types cancer, including NSCLC cancer. Methods: In current study, we synthesized new pyrimidine-tethered compounds (chalcone derivative (B-4), pyrazoline-carbothioamide...
Aim: The present study aims to identify the synthesis and structural characterization of acyl hydrazone- sulfonamide-containing compounds that were tested in vitro on human carbonic anhydrase (hCA) isoforms I, II, IX, XII. Methods: Herein, hydrazone derivatives containing primary sulfonamide moiety synthesized via a three-step synthetic pathway starting from commercially available 4-sulfamoyl benzoic acid. Structural characterizations final assessed through IR IR, 1H-NMR, 13C-NMR, elemental...
The purpose of this study was to synthesize imidazo[2,1-b]thiazole derivatives, characterize them with spectroscopical techniques and investigate for cytotoxic apoptotic effects on glioma C6 cancer cell line. in vitro anticancer activities were also investigated against focal adhesion kinase. Most the compounds, particularly derivatives carrying 3-oxo-1-tiya-4-azaspiro[4.5]decane moiety, exhibited higher or comparable comparison reference drug, cisplatin. Compounds methyl, propyl, phenyl...
Introduction: The genus Euphorbia is known to contain diterpenoids, and several isolated compounds which exhibited biological activities including significant multidrug resistance reversal effects. This work focused on the isolation, in vitro silico studies of two natural bio-active flavonoids (1 & 2) from pulcherrima bark for very first time.Methods: phytochemical investigation resulted identification flavonoids: 3,5,7-trihydroxy-2-(4-hydroxy-3-methoxyphenyl)-6-methoxy-4H-chromen-4-one (1)...
Tumor necrosis factor receptor-associated factors (TRAFs) are a protein family with wide variety of roles and binding partners. Among them, TRAF6, ubiquitin ligase, possesses unique receptor specificity shows diverse functions in immune system regulation, cellular signaling, central nervous system, tumor formation. TRAF6 consists an N-terminal Really Interesting New Gene (RING) domain, multiple zinc fingers, C-terminal TRAF domain. is important therapeutic target for various disorders...
This paper aimed to synthesize novel compounds carrying imidazo[2,1-b]thiazole nucleus, characterize them with various spectroscopic methods, moreover evaluate their antiviral activity.All derivatives were evaluated for activity against Coxsackie B4 virus, Respiratory syncytial Influenza A/H1N1 A/H3N2, and B virus.Some of the compounds, particularly 4methylphenyl 4-bromophenyl moiety, exhibited higher comparable activities both viruses, N-propyl N-butyl at thiazolidinone ring showed high...
Background: Phenylurenyl chalcone structures have the potential to act as a scaffold in anticancer drug discovery. Methods: N-Phenethyl-N'-{4-[(2E)-3-phenylprop-2-enoyl]phenyl}urea, 4/3-[(2E)-3-substitutedphenylprop-2-enoyl]phenyl}-N-phenylurea,4/3-[(2E)-3-substitutedphenyl prop-2-enoyl]phenyl}-N-methylphenyl urea and {4/3-[(2E)-3-substitutedphenylprop-2-enoyl]phenyl}-N-ethylphenyl derivatives(1-35)were prepared evaluated for their antimicrobial activity against A-549 Hep-3B, HT-29, CF-7,...
Coronavirus (SARS-CoV-2) causes a new type of severe acute respiratory syndrome that first appeared in Wuhan December 2019; it is very fast-spreading and deadly virus. Therefore, urgent discovery or development “lead compounds” against this virus crucial. Natural compounds have always served as great source, especially the use traditional medicinal plants, modern drug discovery. This study aimed to investigate SARS-CoV-2 protease inhibition potential phenolic genus Satureja L. The affinities...
Esterification of D-glucose with oleic- and palmitic acids were carried out in the absence presence a biocatalyst, Candida antarctica lipase. The reaction medium was mixture dimethyl sulphoxide tert-butanol (1:4, v/v). products analysed by FTIR, 1H-NMR 13C-NMR, HSQC, ESI-MS. Results indicated that ester formed 6-O-glucose oleate palmitate both yields above 90%.
ABSTRACT Designing new compounds from existing chemotherapeutic drugs to enhance inhibitory effects on tumor cells while overcoming multidrug resistance is one of the important strategies for drug discovery in medicinal chemistry. A series urea and thiourea derivatives based Lenalidomide as potential anticancer agents have been designed synthesized. In vitro activity assay against Caki cancer HUVEC endothelial revealed that...
This study aimed to synthesize a series of 3-substituted piperazinomethyl derivatives (BzO1-4) via Mannich reaction and evaluate their antioxidant activities using 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical scavenging activity ferrous ion- chelation capacity assays. The synthesis process involved precise techniques, the compounds were characterized elemental analysis, FT-IR, 1H-NMR spectroscopy. Notably, BzO-1, featuring 4-methylphenyl substituent, emerged as novel compound within this...
Thiosemicarbazide derivatives have been the focus of scientists owing to their broad biological activities such as anticancer, antimicrobial, and anti-inflammatory. Herein, we designed synthesized a new thiosemicarbazide derivative (TS-1) evaluated its antiproliferative potential against human hepatocellular carcinoma cell line (HEPG2) umbilical vein endothelial (ECV-304). Also, it was aimed investigate necroptotic apoptotic death effects TS-1 in HEPG2 cells, these were supported by...
In this study two different strategy were followed to obtain a D-fructose-oleic acid ester. One of the strategies has been well established enzymatic synthesis an ester bond. The other excluded biocatalyst and only used mixture organic solvents as reaction media, 2-methyl-2-butanol / dimethyl sulfoxide or tert-butanol for production Ester products obtained characterised by using FT-IR, NMR, MS. Product yield was also assessed HPLC. Results structural analyses measurement indicated that...
The title compound, C 19 H N 5 O 3 S 2 , crystallizes in the triclinic space group P -1, with two independent molecules ( A and B ) asymmetric unit Z ′ = 2). imidazo[2,1- b ][1,3]thiazole ring systems are essentially planar (r.m.s deviations 0.004 0.005 Å, respectively), dihedral angles of 1.1 (3) 0.8 (3)°, respectively, between thiazole imidazole rings. mean planes these make 16.0 (2) 61.9 (2)° for molecule 11.8 74.3 1,3-thiazolidine methoxy-substituted benzene rings, respectively. In...
D-ribose-oleic acid esters were produced with or without a biocatalyst, using in the same organic media, dimethyl sulfoxide (DMSO): tert-butanol (TBU) 2-methyl-2-butanol (2M2B). The yield of ester product was above 90% both reactions. biocatalyst used lipase B Candida antarctica. Molecular characterization performed by all analytical methods available: IR, 1H-NMR and 13C-NMR, HSQC, ESI-MS.