A5018801267- Neurological disorders and treatments
- Genetic Neurodegenerative Diseases
- Parkinson's Disease Mechanisms and Treatments
- Botulinum Toxin and Related Neurological Disorders
- Acute Ischemic Stroke Management
- Neuroscience and Neuropharmacology Research
- Cerebrovascular and Carotid Artery Diseases
- Mitochondrial Function and Pathology
- Neurotransmitter Receptor Influence on Behavior
- Transcranial Magnetic Stimulation Studies
- Stroke Rehabilitation and Recovery
- Hereditary Neurological Disorders
- Intracranial Aneurysms: Treatment and Complications
- Neurogenetic and Muscular Disorders Research
- Neurological and metabolic disorders
- Microtubule and mitosis dynamics
- Glycogen Storage Diseases and Myoclonus
- Amyotrophic Lateral Sclerosis Research
- Genetic and rare skin diseases.
- Genomics and Rare Diseases
- Intracerebral and Subarachnoid Hemorrhage Research
- Nerve injury and regeneration
- Genetics and Neurodevelopmental Disorders
- Vascular Malformations Diagnosis and Treatment
- Neurological diseases and metabolism
Tokushima University
2014-2024
Institute of Biomedical Science
2024
Tokushima University Hospital
2013-2024
Massachusetts Institute of Technology
2020
McGovern Institute for Brain Research
2020
Tokyo Metropolitan Institute of Gerontology
2015
Tokyo Metropolitan Geriatric Hospital
2015
Kagawa National Children's Hospital
2011
Boston Children's Hospital
2011
Keio University
1997-2000
Hereditary motor and sensory neuropathy with proximal dominant involvement (HMSN-P) is an autosomal-dominant neurodegenerative disorder characterized by widespread fasciculations, proximal-predominant muscle weakness, atrophy followed distal involvement. To date, large families affected HMSN-P have been reported from two different regions in Japan. Linkage haplotype analyses of previously new the use high-density SNP arrays further defined minimum candidate region 3.3 Mb chromosomal 3q12....
Neuropeptide Y is a novel bioactive substance that plays role in the modulation of neurogenesis and neurotransmitter release, thereby exerts protective influence against neurodegeneration. Using sensitive immunohistochemical method with tyramide signal amplification protocol, we performed post-mortem analysis to determine striatal localization profile neuropeptide neurologically normal individuals patients X-linked dystonia-parkinsonism, major representative neurodegenerative diseases...
Because of its unique ability to exert long-lasting synaptic transmission blockade, botulinum neurotoxin A (BoNT/A) is used treat a wide variety disorders involving peripheral nerve terminal hyperexcitability. However, it has been matter debate whether this toxin central or sites action. We employed rat model in which BoNT/A1 BoNT/A2 was unilaterally injected into the gastrocnemius muscle. On time-course measurements compound muscle action potential (CMAP) amplitudes after injection at doses...
Abnormal motor behaviors in Parkinson's disease (PD) result from striatal dysfunction due to an imbalance between dopamine and glutamate transmissions that are integrated by dopamine- cAMP-regulated phosphoprotein of 32 kDa (DARPP-32). c-Abelson tyrosine kinase (c-Abl) phosphorylates cyclin-dependent 5 (Cdk5) at Tyr15 increase the activity Cdk5, which reduces efficacy dopaminergic signaling phosphorylating DARPP-32 Thr75 striatum. Here, we report mouse striatum, a novel c-Abl inhibitor,...
The brush sign (BS) is the enlargement of medullary veins on 3-T T2*-weighted MRI seen in patients with ischemic stroke because major cerebral artery occlusion. However, clinical relevance BS acute remains unclear. We assessed correlation between detecting development hemorrhagic transformation after intravenous thrombolysis.We enrolled consecutive M1 or M2 occlusion treated tissue plasminogen activator. classified into 2 groups: group positive for (P-BS) and negative (N-BS). investigated...
<b><i>Background:</i></b> A missense mutation of the <i>THAP1</i> gene results in DYT6 primary dystonia. While deep brain stimulation (DBS) internal globus pallidus (GPi) is effective treating dystonia, recent reports indicate that GPi DBS only mildly for <b><i>Objective:</i></b> To describe a patient with dystonia who underwent thalamic ventral lateral anterior (VLa) nucleus DBS. <b><i>Patient:</i></b>...
The opioid peptide receptors consist of three major subclasses, namely, mu, delta and kappa (MOR, DOR KOR, respectively). They are involved in the regulation striatal dopamine functions, increased transmissions thought to play a compensatory role altered functions basal ganglia Parkinson's disease (PD). In this study, we used an immunohistochemistry with tyramide signal amplification protocols determine distributional patterns striosome-matrix systems rat striatum. As most striking feature...
Immunohistochemistry (IHC) is a valuable method for identifying discrete neurochemical molecules by the interaction of target antigens with validated antibodies tagged visible label (e.g., peroxidase). We have developed an immunostaining that highly sensitive in detection antigens. Our IHC involves hybrid protocol implements aspects both polymer and avidin-biotin-complex (ABC) methods combination biotin-tyramide amplification. When using [Met]-enkephalin as antigen, sensitivity PBTA was more...
The human neostriatum consists of two functional subdivisions referred to as the striosome (patch) and matrix compartments. striosome-matrix dopamine systems play a central role in cortico-thalamo-basal ganglia circuits, their involvement is thought underlie genesis multiple movement behavioral disorders, drug addiction. Human neuropathology also has shown that striosomes have differential vulnerability patterns several striatal neurodegenerative diseases. Postsynaptic density protein 95...
✓ In this paper the authors describe two patients with recurrent hemiparesis and limb shaking that gradually progressed to hemichorea. Cerebral angiography confirmed severe unilateral internal carotid artery stenosis (95%) contra-lateral The cerebral blood flow, assessed using N -isopropyl-p-(iodine-123) iodoamphetamine single-photon emission computed tomography (SPECT), disclosed markedly decreased vascular reserves in both patients. After endarterectomy was performed, hemichorea subsided...
Striatal functions depend on the activity balance between dopamine and glutamate neurotransmissions. Glutamate inputs activate cyclin-dependent kinase 5 (Cdk5), which inhibits postsynaptic signaling by phosphorylating DARPP-32 (dopamine- cAMP-regulated phosphoprotein, 32 kDa) at Thr75 in striatum. c-Abelson tyrosine (c-Abl) is known to phosphorylate Cdk5 Tyr15 (Tyr15-Cdk5) thereby facilitates activity. We here report that with phosphorylation (Cdk5-pTyr15) enriched mouse striatum, where...
The dopamine precursor, l-3,4-dihydroxyphenylalanine (l-DOPA), exerts powerful therapeutic effects but eventually generates l-DOPA-induced dyskinesia (LID) in patients with Parkinson's disease (PD). LID has a close link deregulation of striatal dopamine/cAMP signaling, which is integrated by medium spiny neurons (MSNs). Olfactory type G-protein α subunit (Gαolf), stimulatory GTP-binding protein encoded the GNAL gene, highly concentrated striatum, where it positively couples D1 (D1R) receptor...