A5063798649- Neurological disorders and treatments
- Parkinson's Disease Mechanisms and Treatments
- Botulinum Toxin and Related Neurological Disorders
- Genetic Neurodegenerative Diseases
- Amyotrophic Lateral Sclerosis Research
- Hereditary Neurological Disorders
- Parkinson's Disease and Spinal Disorders
- Microtubule and mitosis dynamics
- Gastric Cancer Management and Outcomes
- Neuroscience and Neuropharmacology Research
- Genetics and Neurodevelopmental Disorders
- Neurogenetic and Muscular Disorders Research
- Metastasis and carcinoma case studies
- Genomics and Rare Diseases
- Autoimmune Neurological Disorders and Treatments
- Tryptophan and brain disorders
- Esophageal Cancer Research and Treatment
- Myasthenia Gravis and Thymoma
- NF-κB Signaling Pathways
- Neurosurgical Procedures and Complications
- Nerve injury and regeneration
- Amino Acid Enzymes and Metabolism
- Prion Diseases and Protein Misfolding
- Moyamoya disease diagnosis and treatment
- Cerebrospinal fluid and hydrocephalus
Mukogawa Women's University
2024
Ritsumeikan University
2024
Tokushima University
2011-2024
Osaka Neurological Institute
2022-2024
Kyoto Prefectural Education Center
2022
Kyoto Prefectural University of Medicine
2012-2018
Society for Neuroscience
2014
Neuroscience Institute
2013
Ijinkai Takeda General Hospital
2013
Tokushima University Hospital
2011
Hereditary motor and sensory neuropathy with proximal dominant involvement (HMSN-P) is an autosomal-dominant neurodegenerative disorder characterized by widespread fasciculations, proximal-predominant muscle weakness, atrophy followed distal involvement. To date, large families affected HMSN-P have been reported from two different regions in Japan. Linkage haplotype analyses of previously new the use high-density SNP arrays further defined minimum candidate region 3.3 Mb chromosomal 3q12....
Neuropeptide Y is a novel bioactive substance that plays role in the modulation of neurogenesis and neurotransmitter release, thereby exerts protective influence against neurodegeneration. Using sensitive immunohistochemical method with tyramide signal amplification protocol, we performed post-mortem analysis to determine striatal localization profile neuropeptide neurologically normal individuals patients X-linked dystonia-parkinsonism, major representative neurodegenerative diseases...
Because of its unique ability to exert long-lasting synaptic transmission blockade, botulinum neurotoxin A (BoNT/A) is used treat a wide variety disorders involving peripheral nerve terminal hyperexcitability. However, it has been matter debate whether this toxin central or sites action. We employed rat model in which BoNT/A1 BoNT/A2 was unilaterally injected into the gastrocnemius muscle. On time-course measurements compound muscle action potential (CMAP) amplitudes after injection at doses...
<b><i>Background:</i></b> A missense mutation of the <i>THAP1</i> gene results in DYT6 primary dystonia. While deep brain stimulation (DBS) internal globus pallidus (GPi) is effective treating dystonia, recent reports indicate that GPi DBS only mildly for <b><i>Objective:</i></b> To describe a patient with dystonia who underwent thalamic ventral lateral anterior (VLa) nucleus DBS. <b><i>Patient:</i></b>...
Imbalanced activities between dopamine D
Nuclear factor κ B (NF-κB) is involved in the pathogenesis of a number neurodegenerative disorders with neuroinflammation. In order to clarify role NF-κB ALS, immunohistochemical studies an antibody that recognizes p65 subunit were performed on spinal anterior horn 4 patients sporadic ALS (sALS), 1 patient optineurin-mutated (OPTN-ALS), and 3 normal controls (NC). sALS or OPTN-ALS, expression pattern was altered when compared NC; immunoreactivity tended be absent from neuronal nucleus...
The opioid peptide receptors consist of three major subclasses, namely, mu, delta and kappa (MOR, DOR KOR, respectively). They are involved in the regulation striatal dopamine functions, increased transmissions thought to play a compensatory role altered functions basal ganglia Parkinson's disease (PD). In this study, we used an immunohistochemistry with tyramide signal amplification protocols determine distributional patterns striosome-matrix systems rat striatum. As most striking feature...
The gold standard for the diagnosis of idiopathic normal pressure hydrocephalus (iNPH) is CSF removal test. For elderly patients, however, a less invasive diagnostic method required. On MRI, high-convexity tightness was reported to be an important finding iNPH. SPECT, patients with iNPH often show hyperperfusion area. authors tested 2 hypotheses regarding SPECT finding: 1) it relative reflecting increased gray matter density convexity, and 2) useful termed convexity apparent (CAPPAH) sign.
Striatal functions depend on the activity balance between dopamine and glutamate neurotransmissions. Glutamate inputs activate cyclin-dependent kinase 5 (Cdk5), which inhibits postsynaptic signaling by phosphorylating DARPP-32 (dopamine- cAMP-regulated phosphoprotein, 32 kDa) at Thr75 in striatum. c-Abelson tyrosine (c-Abl) is known to phosphorylate Cdk5 Tyr15 (Tyr15-Cdk5) thereby facilitates activity. We here report that with phosphorylation (Cdk5-pTyr15) enriched mouse striatum, where...
Blepharospasm is typically diagnosed by excluding any secondary diseases and neuropsychiatric disorders, as specific tests for blepharospasm are currently unavailable. Since anticholinergic agents used to improve the symptoms of dystonia, we hypothesized that edrophonium chloride, an acetylcholinesterase inhibitor, may make dystonia more apparent. Therefore, examined whether challenge test would be useful diagnosing blepharospasm.We studied 10 patients with hemifacial spasms (as disease...
Isolated dystonia is a rare movement disorder characterized by involuntary, repetitive, sustained muscle contractions or postures of the entire body, occasionally resulting from actions DYT1 gene DYT6 gene. There are several treatment options, including pharmacological therapies such as use anticholinergics (most commonly trihexiphenydil) and surgical approaches DBS internal globus pallidus (GPi-DBS). However, these treatments notoriously difficult often unsuccessful. Zolpidem, an...
Impairment of balanced activity between dopamine D1 and D2 receptor functions in the striatum, particularly striatal functional subdivisions (i.e., striosome matrix compartments), has been proposed to underlie dystonia genesis. This study was undertaken examine therapeutic effect dual dopaminergic modulation with L-3,4-dihydroxyphenylalanine (L-DOPA) chlorpromazine (CPZ) patients blepharospasm, a focal dystonia. For this purpose, Dopacol tablets™ (L-DOPA 50 mg plus carbidopa 5 mg) Wintermin™...
Although there are some newly-developed options to treat dystonia, its medical treatment is not always satisfactory. Zolpidem, an imidazopyridine agonist with a high affinity benzodiazepine receptor subtype ω1, has been reported improve clinical symptoms of dystonia in cases. We conducted open-label study assess the efficacy zolpidem 34 patients primary patients, The Burke Fahn Marsden Dystonia Rating Scale (BFMDRS) scores were decreased from 7.2 ± 7.9 5.5 5.0 after therapy (P=0.042). Next...
Objective To examine whether or not an edrophonium challenge test is useful for diagnosing cervical dystonia. Patients We evaluated 10 patients with dystonia and hemifacial spasms (disease controls). administered saline in this double-blinded study. Before after the injection, we recorded participants' clinical signs using a video camera to assess objective symptoms every two minutes. Ten minutes injections, participants their subjective visual analog scale. The on recordings were scored by...
A 56-year-old man with anti-acetylcholine receptor antibody-mediated myasthenia gravis had bilateral facial muscular atrophy and noticed blepharoptosis 15 years earlier. From 45 to 51 of age, 5-10 mg prednisolone 180 pyridostigmine daily relieved his symptoms. Subsequently, these treatments no longer improved the weakness, though was absent. At 56 edrophonium test repetitive supramaximal stimulation testing orbicularis oris were negative. Frontalis muscle needle electromyography showed low...
Dystonia is a rare movement disorder with some cases being difficult to treat. Although dystonia can occur as symptom of moyamoya disease, few studies have reported truncal occurring middle cerebral artery (MCA) stenosis. Here, we report case MCA occlusion.The patient was 48-year-old female clerical worker who lived alone. An abnormal cervical posture initially appeared 7 years before (right flexion). Symptoms improved medication and botulinum toxin injection. Five this report, her symptoms...
OBJECTIVE: We present the clinicopathological characteristics of patients with amyotrophic lateral sclerosis (ALS) who experienced precedent parkinsonism. BACKGROUND: ALS is characterized by TAR DNA-binding protein 43 kD (TDP-43) proteinopathy and Parkinson disease (PD) α-synucleinopathy. However, coexistence two has not been demonstrated. DESIGN/METHODS: Among 180 resistered from July 2007 to September 2013, 3 (1.6%) presented parkinsonism before developing ALS-related symptoms. All...