A5100422511- Extracellular vesicles in disease
- RNA Interference and Gene Delivery
- MicroRNA in disease regulation
- Angiogenesis and VEGF in Cancer
- Nanoplatforms for cancer theranostics
- Circular RNAs in diseases
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Advanced Nanomaterials in Catalysis
- Clostridium difficile and Clostridium perfringens research
- Gut microbiota and health
- Helicobacter pylori-related gastroenterology studies
- Gastrointestinal motility and disorders
- Chemokine receptors and signaling
- Immune Cell Function and Interaction
- Drug Transport and Resistance Mechanisms
- Prenatal Screening and Diagnostics
- MXene and MAX Phase Materials
- Cerebrovascular and Carotid Artery Diseases
- Nanoparticle-Based Drug Delivery
- Inflammatory Biomarkers in Disease Prognosis
- Congenital Heart Disease Studies
- Graphene and Nanomaterials Applications
- Medical and Biological Ozone Research
- Psoriasis: Treatment and Pathogenesis
- Cardiovascular, Neuropeptides, and Oxidative Stress Research
Shanghai East Hospital
2025
Lishui Maternity and Child Health Care Hospital
2025
Shanghai Jiao Tong University
2018-2024
Jiangsu University
2020-2024
Affiliated Hospital of Jiangsu University
2020-2024
Shanghai Sixth People's Hospital
2019-2024
Nanjing University of Chinese Medicine
2024
Sichuan University
2023
West China Hospital of Sichuan University
2023
Shanghai Children's Hospital
2018-2022
Reactive oxygen species (ROS) are generated and consumed in living organism for normal metabolism. Paradoxically, the overproduction and/or mismanagement of ROS have been involved pathogenesis progression various human diseases. Here, we reported a two-dimensional (2D) vanadium carbide (V2C) MXene nanoenzyme (MXenzyme) that can mimic up to six naturally-occurring enzymes, including superoxide dismutase (SOD), catalase (CAT), peroxidase (POD), glutathione (GPx), thiol (TPx) haloperoxidase...
Abstract Evidence is accumulating that extracellular microvesicles (MV) facilitate progression and relapse in cancer. Using a model which MVs derived from K562 chronic myelogenous leukemia (CML) cells transform normal hematopoietic transplants into leukemia-like cells, we defined the underlying mechanisms of this process through gene-expression studies network analyses transcription factors (TF) miRNAs. We found antitumor miRNAs were increased several defense pathways initiated during early...
Exosomes derived from bone mesenchymal stem cells (BMSC-Exos) are one of the main factors responsible for therapeutic effects BMSCs. The study aimed to investigate whether BMSC-Exos could promote angiogenesis in ischemic stroke mice via miR-21-5p. In mice, were evaluated by neurological functions and infarct volume. Microvessel density was detected BrdU/vWF immunofluorescence staining. vitro experiments, proangiogenic assessed proliferation, migration, tube formation human umbilical vein...
Abstract Background: Our previous studies observed that administration of exosomes from endothelial progenitor cells (EPC) facilitated vascular repair in the rat model balloon injury. However, molecular events underlying this process remain elusive. Here, we aim to interrogate key miRNAs within EPC-derived (EPC-exosomes) responsible for activation cell (EC) repair. Methods: The efficacy EPC-exosomes re-endothelialization was examined by Evans Blue dye and histological examination...
Liver health, fecal bile acid (BA) concentrations, and gut microbiota composition are closely connected. BAs the microbiome influence each other in gut, where bacteria modify BA profile, while intestinal regulate growth of commensal bacteria, maintain barrier integrity, modulate immune system. Previous studies have found that co-occurrence dysbiosis metabolism alteration is present many human liver diseases. Our study first to assess infantile cholestatic jaundice (CJ) elucidate linkage...
<h3>BACKGROUND AND PURPOSE:</h3> Carotid web was recognized as a cause of ischemic stroke. We sought to determine the clinical and imaging profiles patients with carotid well its association TIA. <h3>MATERIALS METHODS:</h3> A retrospective review CT angiography studies brain MR in TIA during past 3 years (<i>n</i> = 135) performed presence webs by 2 experienced neuroradiologists according previously published criteria. Demographics characteristics are shown descriptive statistics for an...
Abstract Photothermal therapy (PTT) is a minimally invasive and highly specific antineoplastic treatment, whereas the significant upregulation of TXNDC5 gene expression following PTT cripples photothermal ablation efficacy through protein processing in endoplasmic reticulum signaling pathway, as transcriptome sequencing bioinformatics analysis revealed this research. To tackle crucial issue, second near‐infrared biowindow (NIR‐II) light‐controlled CRISPR/Cas9 nanosystem (silicene‐Cas9)...
This study evaluated the utility of single nucleotide polymorphism (SNP) microarray analysis in prenatal genetic assessment fetuses diagnosed with congenital heart disease (CHD), retrospectively analyzing pregnancy outcomes and their association physical intellectual development within first year life. It included 105 CHD via echocardiography from January 2016 to June 2020, categorized into two groups: isolated cardiac structural abnormalities (76 cases) additional extracardiac (29 cases)....
Fecal microbiota transplantation (FMT) has been shown as an effective treatment for recurrent clostridium difficile infection (RCDI) in adults. In this study, we aim to evaluate the clinical efficacy of FMT treating children with RCDI, and explore fecal changes during treatment. A total 11 RCDI subjects a median age 3.5 years were enrolled single-center prospective pilot study. All patients cured (11/11, 100%) by either through upper gastrointestinal tract route nasointestinal tube (13/16,...
Abstract Background Endothelial progenitor cell (EPC) dysfunction contributes to vascular disease in diabetes mellitus. However, the molecular mechanism underlying EPC and its contribution delayed reendothelialization mellitus remain unclear. Our study aimed illustrate potential diabetic vivo vitro. Furthermore, we assessed effect of transplantation on endothelial regeneration rats. Methods Late outgrowth EPCs were isolated from bone marrow rats for vitro studies. In functional assays...
Exclusive enteral nutrition (EEN) can induce remission in patients with pediatric Crohn's disease (CD). This study aims to depict EEN's modification of bile acid (BA) metabolism CD and explores the effect EEN-enriched BA inhibiting inflammatory response. The twelve enrolled showed dysmetabolism, represented by decreased levels fecal secondary unconjugated BAs as determined UPLC-TQMS, which were accompanied gut microbiota dysbiosis reduced BA-metabolizing bacteria including Eubacterium...
Abstract Background Beckwith-Wiedemann syndrome (BWS) is a genetic overgrowth disorder with variable clinical features and cancer predisposition. In this study, we aim to characterize the molecular defects of BWS patients in China. Methods Thirty-one suspicion were retrospectively recruited study from Shanghai Children’s Hospital between January 2014 December 2017. Clinical data, including demographics, features, testing results extracted systematically analyzed. Results Twenty-one score ≥ 4...
Fecal microbiota transplantation (FMT) is the administration of fecal bacterial liquid from healthy donors to a recipient's digestive tract, which recommended as therapeutic method for recurrent Clostridium difficile infection (CDI). Many clinical trials focusing on different diseases are in progress. To date, scarce research and long-term follow-up have been conducted FMT children or proper guidelines. Our center first performed treat 13-month-old boy with severe CDI 2013. Until February...
The present study was conducted to assess the effects of AMD3100 and stromal cell-derived factor 1 (SDF-1) on cellular functions endothelial regeneration progenitor cells (EPCs). cell proliferation adhesion capacity EPCs were evaluated in vitro following treatment with SDF‑1 using a Cell Counting Kit‑8 assay. Furthermore, expression levels C‑X‑C motif chemokine receptor 4 (CXCR4) 7 (CXCR7) detected before after elucidate their possible role regulating function EPCs. A rat carotid artery...
Clostridiodes difficile infection (CDI) is one of the most common causes antibiotic-associated diarrhea in children. Conventional antibiotics and emerging fecal microbiota transplantation (FMT) are used to treat CDI. Children with CDI admitted Shanghai Children's Hospital, from September 2014 2020, were retrospectively included this observational study. Pediatric patients assigned as initial recurrent (RCDI), symptoms, comorbidities, imaging findings, laboratory tests, treatments...
The effect of metformin on human esophageal normal and carcinoma cells remains poorly understood. We aim to investigate the different antiproliferation effects underlying distinct molecular mechanisms between these two types cells. Human squamous cell line, EC109, epithelial HEEC, were used in experiment. survival rate was determined by counting kit-8 (CCK-8). Cell apoptosis analyzed flow cytometry. mRNA protein levels signal transducer activator transcription 3 (Stat3) detected real-time...
To evaluate the efficacy and safety of fecal microbiota transplantation (FMT) in functional gastrointestinal disorders (FGIDs) children with abdominal bloating changes their gut microbiome metabolome.Twelve pediatric FGID patients predominant who underwent FMT were enrolled study. Fourteen healthy controls four stool donors included for analysis. Clinical responses assessed at 8 weeks after FMT. Fecal bacterial composition was determined by 16S rRNA gene sequencing. The metabolome measured...