A5086783961- Legionella and Acanthamoeba research
- Respiratory viral infections research
- Viral gastroenteritis research and epidemiology
- Heme Oxygenase-1 and Carbon Monoxide
- Vaccine Coverage and Hesitancy
- Vibrio bacteria research studies
- COVID-19 Clinical Research Studies
- Influenza Virus Research Studies
- COVID-19 Impact on Reproduction
- Kawasaki Disease and Coronary Complications
- COVID-19 Pandemic Impacts
- COVID-19 and Mental Health
- Herpesvirus Infections and Treatments
- Viral Infections and Vectors
- Infection Control and Ventilation
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Enterobacteriaceae and Cronobacter Research
- Cerebrospinal fluid and hydrocephalus
- Parasites and Host Interactions
- Rabies epidemiology and control
- Research on Leishmaniasis Studies
- Clostridium difficile and Clostridium perfringens research
- COVID-19 epidemiological studies
- Food Safety and Hygiene
- Virology and Viral Diseases
Centers for Disease Control and Prevention
2021-2024
Waterborne Environmental (United States)
2023-2024
National Center for Emerging and Zoonotic Infectious Diseases
2023-2024
Epidemic Intelligence Service
2022-2023
Oak Ridge Associated Universities
2023
Oak Ridge Institute for Science and Education
2023
Computer Emergency Response Team
2022
Emory University
2019
Children's Healthcare of Atlanta
2019
Medical University of South Carolina
2016-2017
During June 2021, the highly transmissible† B.1.617.2 (Delta) variant of SARS-CoV-2, virus that causes COVID-19, became predominant circulating strain in United States. U.S. pediatric COVID-19-related hospitalizations increased during July-August 2021 following emergence Delta and peaked September 2021.§ As May 12, CDC recommended COVID-19 vaccinations for persons aged ≥12 years,¶ on November 2, were 5-11 years.** To date, clinical signs symptoms, illness course, factors contributing to...
Genomic DNA was extracted and sequenced on MiSeq instruments (Illumina) following Nextera XT or Prep
Recent population-based data are limited regarding influenza-associated hospitalizations in US children.We identified children <18 years hospitalized with laboratory-confirmed influenza during 2010-2019 seasons, through the Centers for Disease Control and Prevention's Influenza Hospitalization Surveillance Network. Adjusted hospitalization in-hospital mortality rates were calculated, multivariable logistic regression was conducted to evaluate risk factors pneumonia, intensive care unit (ICU)...
Granulomatous amebic encephalitis, caused by the free-living amebae Balamuthia mandrillaris or Acanthamoeba species, is a rare and deadly infectious syndrome with current mortality rate of >90%. Much work remains to define optimal treatment for these infections. Here, we provide comprehensive overview supporting evidence behind antimicrobials currently recommended Centers Disease Control Prevention (CDC) updated statistics on survival rates medication usage from CDC Free-Living Ameba...
Washing hands often, especially during times when one is likely to acquire and spread pathogens,* important measure help prevent the of SARS-CoV-2, virus that causes coronavirus disease 2019 (COVID-19), as well other pathogens by respiratory or fecal-oral transmission (1,2). Studies have reported moderate high levels self-reported handwashing among adults worldwide COVID-19 pandemic (3-5)†; however, little known about how behavior U.S. has changed since start pandemic. For this study, survey...
Abstract Background Acanthamoeba is a free-living ameba that can cause severe disease affecting the central nervous system, skin, sinuses, and other organs, particularly in immunocompromised individuals. These rare but infections are often fatal, yet incompletely described. Methods Cases included were either reported to Centers for Disease Control Prevention (CDC) Free-Living Ameba program or published scientific literature. Characteristics of all patients United States with...
Abstract Background Free-living amebae (FLA) including Acanthamoeba spp., Balamuthia mandrillaris, and Naegleria fowleri live in soil water worldwide cause severe infections humans. Approximately 15 people the United States are infected by FLA each year; most do not survive. Early diagnosis treatment improve outcomes. Targeted testing options for require tissue or cerebrospinal fluid (CSF) offered at &lt; 5 laboratories U.S., making it challenging to diagnose quickly non-invasively....
A fatal case of primary amebic meningoencephalitis (PAM), an infection caused by Naegleria fowleri, was diagnosed in Arkansas a young child September 2023. public health investigation completed, with epidemiologic, laboratory, and environmental data suggesting that splash pad (an interactive water play venue sprays or jets on users has little no standing water) inadequately disinfected the most likely site patient's N. fowleri exposure. This is third occurrence pad-associated PAM reported...
Abstract Background Encephalitis is an inflammatory condition of the brain associated with long-term neurologic sequelae and even death in children. Although viruses are often implicated, etiology not identified majority cases. Metagenomics-based next-generation sequencing (mNGS) a high-throughput technique that can enhance detection novel or low-frequency pathogens. Methods Hospitalized immunocompetent children aged 6 months to 18 years encephalitis unidentified were eligible for...
To describe coronavirus disease 2019 (COVID-19)-related pediatric hospitalizations during a period of B.1.617.2 (Δ) variant predominance and to determine age-specific factors associated with severe illness.
Abstract We describe 10 patients with nonkeratitis Acanthamoeba infection who reported performing nasal rinsing before becoming ill. All were immunocompromised, 7 had chronic sinusitis, and many used tap water for rinsing. Immunocompromised persons should be educated about safe to prevent free-living ameba infections.
Tap water is not sterile, and its use in home medical devices can result infections from waterborne pathogens. However, many participants a recent survey the United States said tap could safely be used for devices. These results inform communication materials to reduce high consequence of infections.
ABSTRACT We report a case of Acanthamoeba infection in an HCT recipient with steroid‐refractory GVHD. highlight the multiple challenges that free‐living ameba infections present to clinician, clinical laboratory, transplant infectious disease for review, hospital epidemiology if nosocomial transmission is considered, and public health officials, as exposure source identification can be significant challenge. Transplant physicians should include their differential diagnosis patient skin,...
Abstract Background Shigellosis is an acute diarrheal disease transmitted through contaminated food, water, objects, poor hand hygiene, or sexual activity. Healthcare providers (HCP) may not be aware of the multiple routes Shigella transmission, populations at increased risk, importance antibiotic susceptibility testing (AST). This study assessed HCP knowledge and clinical practices regarding shigellosis resistance. Methods Porter Novelli Public Services administered a web-based survey (Fall...
OBJECTIVES/SPECIFIC AIMS: The overall goal of this project is to determine whether timing seasonal influenza vaccination affects the severity illness in vaccinated individuals who are hospitalized with influenza. This will be assessed following aims: 1. To differences demographic and clinical characteristics exist among patients short duration between influenza-related hospitalization those longer duration. 2. time associated hospitalization. 3. rate ICU admission 4. death adults...
Abstract Background Seasonal influenza vaccine may attenuate disease severity among people infected with despite vaccination, but effectiveness decrease increasing time between vaccination and infection. Patient characteristics play a role in the timing of receipt. Methods We used data from Influenza Hospitalization Surveillance Network (FluSurv-NET) included patients ≥ 9 years hospitalized laboratory-confirmed during October 1–April 30 seasons 2013–2014 through 2016–2017 who received...