A5077367312- Occupational and environmental lung diseases
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Mosquito-borne diseases and control
- Medical Imaging and Pathology Studies
- Insect symbiosis and bacterial influences
- SARS-CoV-2 detection and testing
- Aluminum toxicity and tolerance in plants and animals
- Carcinogens and Genotoxicity Assessment
- Viral gastroenteritis research and epidemiology
- Occupational exposure and asthma
- Chronic Disease Management Strategies
- Viral Infections and Vectors
- Cancer Research and Treatments
- Metabolism, Diabetes, and Cancer
- Cancer, Lipids, and Metabolism
- Pleural and Pulmonary Diseases
- Reproductive System and Pregnancy
- Blood Pressure and Hypertension Studies
- Endoplasmic Reticulum Stress and Disease
- Bone and Dental Protein Studies
- Diabetes Treatment and Management
- Renin-Angiotensin System Studies
- Endometriosis Research and Treatment
- Biomarkers in Disease Mechanisms
St. George's University
2019-2025
University of Vermont
2004-2023
Only a fraction of subjects exposed to asbestos develop malignant mesothelioma (MM), suggesting that additional factors may render some individuals more susceptible. We tested the hypothesis and Simian virus (SV40) are cocarcinogens. Asbestos SV40 in combination had costimulatory effect inducing ERK1/2 phosphorylation activator protein-1 (AP-1) activity both primary Syrian hamster mesothelial cells (SHM) human (HM). Ap-1 caused expression activation matrix metalloprotease (MMP)-1 MMP-9,...
Peroxisome proliferator-activated receptors (PPARs) have emerged as important drug targets for diabetes. Drugs that activate PPARγ, such the thiazolidinediones (TZDs), are widely used treatment of Type 2 diabetes mellitus. PPARγ signaling could also play an anti-neoplastic role in several vitro models, although conflicting results reported from vivo models. The effects TZDs on cancer risk humans needs to be resolved these drugs prescribed long periods time patients with A total 1003 subjects...
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The ligand hepatocyte growth factor/scatter factor (HGF) and its receptor tyrosine kinase, c-Met, are highly expressed in most human malignant mesotheliomas (MMs) may contribute to their increased viability. Based upon our observation that RNA silencing of fos-related antigen 1 (Fra-1) inhibited c-met expression rat (1), we hypothesized Fra-1 was a key player HGF-induced proliferation MMs. In three seven MM lines evaluated, HGF levels phosphorylation both extracellular signal-regulated...
Human mesothelial cells (LP9/TERT-1) were exposed to low and high (15 75 microm(2)/cm(2) dish) equal surface area concentrations of crocidolite asbestos, nonfibrous talc, fine titanium dioxide (TiO2), or glass beads for 8 24 hours. RNA was then isolated Affymetrix microarrays, GeneSifter analysis QRT-PCR. Gene changes by asbestos concentration- time-dependent. At nontoxic concentrations, caused significant in mRNA expression 29 genes at hours 205 hours, whereas levels 236 occurred primary...
Antimicrobial resistance (AMR) is a growing global health threat. This study investigated antibiotic in E. coli isolates from municipal wastewater (86 isolates) and clinical urinary tract infection (UTI) cases (34 Grenadian community, using data January 2022 to October 2023. Antibiogram data, assessed per WHO guidelines for Critically Important antimicrobials (CIA), showed the highest levels both samples ampicillin, followed by amoxicillin/clavulanic acid nalidixic acid, all classified as...
Wastewater-based epidemiology (WBE) is a valuable tool for monitoring pathogen spread in communities; however, current protocols mainly target non-enveloped viruses. This study addresses the need standardized methods to detect both enveloped and viruses by testing four aluminum hydroxide adsorption–precipitation techniques. Wastewater samples were spiked with an virus surrogate (Φ6 bacteriophage) (MS2 coliphage), viral recovery was assessed using reverse-transcription quantitative PCR...
The mosquitoes Aedes aegypti (Linnaeus, 1762) (Diptera: Culicidae) and Culex quinquefasciatus Say, 1823 are two major vectors of arthropod-borne pathogens in Grenada, West Indies. As conventional vector control methods present many challenges, alternatives urgently needed. Manipulation mosquito microbiota is emerging as a field for the development strategies. Critical to this approach knowledge these finding candidate microorganisms that common with properties could be used modification...
Arboviruses cause diseases of significant global health concerns. Interactions between mosquitoes and their microbiota as well the important role this interaction in mosquito's capacity to harbor transmit pathogens have emerged fields research. Aedes aegypti is one most abundant many geographic locations, a vector capable transmitting number arboviruses such dengue Zika. Currently, there are few studies on metavirome mosquito particularly Americas. This study analyzes A. from Grenada,...
Abstract Malignant mesothelioma is an aggressive cancer with no known cure, which has become a therapeutic challenge. Onconase one of few chemotherapeutic agents that have been studied in patients malignant the advantage low toxicity and limited side effects. Here, we evaluate effect on killing cells how phosphatidylinositol 3-kinase/AKT (PI3-K/AKT) survival pathway influences this effect. Our results show induces apoptosis cell lines tumor specific. highest AKT activation, correlated...
Abstract New and effective treatment strategies are desperately needed for malignant mesothelioma (MM), an aggressive cancer with a poor prognosis. We have shown previously that acid‐prepared mesoporous microspheres (APMS) nontoxic after intrapleural or intraperitoneal (IP) administration to rodents. The purpose here was evaluate the utility of APMS in delivering chemotherapeutic drugs human MM cells vitro two mouse xenograft models MM. Uptake release doxorubicin (DOX) alone loaded...
Abstract Blood-feeding patterns of mosquitoes affect the transmission and maintenance arboviral diseases. In Caribbean, Aedes aegypti (L.) Culex quinquefasciatus Say are dominant mosquito species in developed areas. However, no information is available on bloodmeal hosts these invasive vectors Grenada, where pathogens such as dengue, chikungunya, Zika viruses cause significant human suffering. To this end, Ae. Cx. were investigated from five semirural locations near houses St. George’s...
Silencing of Fra-1, a component the dimeric transcription factor, activator protein-1 (AP-1), inhibits mRNA expression c-met and cd44 in rat mesothelioma cells is causally linked to maintenance transformed phenotype. However, mechanisms Fra-1 regulation regulated gene human malignant (MM) are unclear. We first show panel MM that complex by extracellular signal-regulated kinase (ERK1, ERK2), Src, phosphatidyl-inositol-3-kinase (PI3K) pathways tumor-specific fashion. Cell lines with...