A5061377370- Sesquiterpenes and Asteraceae Studies
- Natural product bioactivities and synthesis
- Essential Oils and Antimicrobial Activity
- Phytochemistry and Biological Activities
- Plant Toxicity and Pharmacological Properties
- Plant tissue culture and regeneration
- Microbial Natural Products and Biosynthesis
- Marine Sponges and Natural Products
- Traditional Chinese Medicine Analysis
- Plant biochemistry and biosynthesis
- Natural Antidiabetic Agents Studies
- Metabolomics and Mass Spectrometry Studies
- Fungal Biology and Applications
- SARS-CoV-2 and COVID-19 Research
- Traditional and Medicinal Uses of Annonaceae
- Magnolia and Illicium research
- Allelopathy and phytotoxic interactions
- Phytochemicals and Antioxidant Activities
- Cholesterol and Lipid Metabolism
- Medicinal Plants and Bioactive Compounds
- Insect Pest Control Strategies
- Phytochemistry and Bioactive Compounds
- Transgenic Plants and Applications
- Nephrotoxicity and Medicinal Plants
- Synthesis and Biological Activity
Assiut University
2021-2024
Sphinx University
2021-2024
Deraya University
2018-2020
Minia University
2018-2019
Ibb University
2016
Beni-Suef University
2016
Applied Science Private University
2010
<p><strong>Objective:</strong><strong> </strong>To evaluate the <em>in vitro</em> cytotoxicity, antioxidant activities and structure-activity relationship of secondary metabolites isolated from <em>Pulicaria undulata</em>.</p><p><strong>Methods: </strong>The methylene chloride-methanol (1:1) extract air-dried aerial parts undulata</em> was fractionated separated to obtain compounds by different...
Abstract The Egyptian Sinai is a rich source of plant‐derived medicines from the highly represented Asteraceae family; however, protocol for effective chemical extraction has not been standardized. To identify an method essential oils species, Achillea fragrantissima , Artemisia judaica and Tanacetum sinaicum were analysed by hydro‐distillation (HD) vs microwave‐assisted (MA) extraction. A total 82 metabolites identified gas chromatography‐mass spectrometry (GC‐MS). While oxygenated...
Abstract The aerial parts of Centaureaa egyptiaca afforded 10 secondary metabolites including four sesquiterpene lactones; chlorohyssopifolin A (centaurepensin) ( 1 ), rediolpidetriol 2 linichlorinA 3 and sinaicin 4 one monoterpene; loliolid 5 phenolic: tyrosol 6 three lignans; arctigenin 7 matairesinol 8 pinoresinol 9 steroid; ergosta‐5,22‐dien‐3‐ol ). cluster analysis 32 Centaurea species revealed that C. aegyptiaca is closely related to repens solstitialise . isolated compounds – ) were...
Centaurothamnus maximus (family Asteraceae), is a leafy shrub indigenous to the southwestern Arabian Peninsula. With paucity of phytochemical data on this species, we set out chemically characterize plant. From aerial parts, two newly identified guaianolides were isolated: 3β-hydroxy-4α(acetoxy)-4β(hydroxymethyl)-8α-(4-hydroxy methacrylate)-1αH,5αH, 6αH-gual-10(14),11(13)-dien-6,12-olide (1) and 15-descarboxy picrolide A (2). Seven previously reported compounds also 3β, 4α,...
Three new cembrenoids, lobophylins F-H (1–3), along with three known ones, A-C (4–6), were isolated from the ethyl acetate extract of Taiwan water soft coral Lobophytum crassum. The structures cembrenoids elucidated on basis extensive spectroscopic methods such as IR, 1D, 2D NMR and HR–ESI–MS.
Since ancient times, the three Salvia L. species: aegyptiaca L., lanigera Poir., and multicaulis Vahl, have been utilised in traditional medicine all across world. These species are now subjected to in-depth chemical pharmacological investigations order find physiologically active chemicals. In present study, essential oil composition biological activity of these were studied. Using various extraction methods: hydrodistillation (HD) microwave-assisted (MAHD) compare efficiency, volatile...
Genus Stachys, the largest genera of family Lamiaceae, and its species are frequently used as herbal teas due to their essential oils. Tubers some Stachys also consumed important nutrients for humans animals carbohydrate contents. Three new neo-clerodane diterpene peroxides, named stachaegyptin F-H (1, 2, 4), together with two known compounds, stachysperoxide (3) A (5), were isolated from aegyptiaca aerial parts. Their structures determined using a combination spectroscopic techniques,...
Soft corals are recognized as an abundant source of diverse secondary metabolites with unique chemical features and physiologic capabilities. However, the discovery these is usually hindered by traditional protocol which requires a large quantity living tissue for isolation spectroscopic investigations. In order to overcome this problem, untargeted metabolomics protocols have been developed. The latter applied here study chemodiversity common Egyptian soft coral species, using only minute...
A new cadinane-type sesquiterpene glucoside, 10α-hydroxy, 1α(H), 6β(H), 7β(H), 8β(H)-cadinane-4-en-8-O-β-D-glucoside (1) as well as, 2 known analogues [sinaicin (2)- linichlorinA (3)], were isolated from the CH2Cl2:MeOH organic extract of Centaurea alexandrina. Chemical structures all compounds established depending upon spectroscopic data including, 1D and 2D NMR HRMS. Colo-205 (colorectal cancer), HepG2 (hepatocellular carcinoma) MCF-7 (breast adenocarcinoma) cancer cell lines used to test...
In the current study, both essential oil composition and biological activity of Saussurea lappa Ligusticum sinensis were investigated by means microwave-assisted hydrodistillation (MAHD) characterized Gas chromatography/mass spectrometry (GC/MS), whereas antimicrobial efficiency MAHD oils was examined against four pathogens: Staphylococcus aureus, Escherichia coli, Aspergillus niger, Candida albicans responsible for microbial infections. The goal to spot synergy a favorable method that gives...
A NEW metabolite, a phenolic derivative, 2-tert-butyl-4-(2-methylhex-5-en-2-yl) phenol(1), together with three known phthalates (2-4), was first isolated from the endophytic fungus Gymnoascus thermotolerans which collected roots, stems, and leaves of Euphorbia geniculata for time.The structures were determined by mass spectrometric measurements, 1D 2D NMR investigations, spectroscopic analyses.The antibacterial, antioxidant, cytotoxic properties these metabolites assessed in...
Ageratum conyzoides L., is an annual herb with a long history of traditional medicinal uses in many countries the world, especially tropical and subtropical regions. A wide range chemical compounds including alkaloids, flavonoids, chromenes, benzofurans terpenoids have been isolated from this species. Extracts metabolites plant found to possess pharmacological insecticidal activities. In continuation our interest Egyptian plants, reinvestigation methylenechloride extract air-dried aerial...
The methylene chloride-methanol (1:1) extract of the air-dried aerial parts Magnolia grandiflora was fractionated and separated to obtain isolated compounds by different chromatographic techniques. Structures were determined on basis extensive spectroscopic analysis, including 1D 2D NMR compared with literature data. Three secondary metabolites from in this study. Of which two sesquiterpenoidal compounds; parthenolide (1) 1,10-epoxy-parthenolide (2), together an aromatic compound identified...
Due to the rapidly increasing number of pathogenic bacteria, viruses, and tumor cells that possess resistance toward established therapies, lead structures for development new drugs are in high demand. The plant material Tanacetum sinaicum is considered a prolific source potent biologically active sesquiterpene Tanacetolide A ( 1 ). In our research, we focused on structural transformation substrate (compound ) by suspended culture novel locally isolated terrestrial fungus Rhizopus oryzae...
The plant selected for the present study was Saussurea costus (Falc.) Lipsch, which belongs to Asteraceae family. S. roots are used traditionally cure a variety of conditions, including infection in throat, dysentery, ulcers, and asthma. Studies have shown that wide range therapeutic effects, anti-oxidant, anti-tumor, hepatoprotective, anti-inflammatory. In study, pharmacognostical evaluation done provide supplementary information on identification parameters costus. This includes...