A5051309714- Malaria Research and Control
- Mosquito-borne diseases and control
- Parasites and Host Interactions
- Vibrio bacteria research studies
- Child Nutrition and Water Access
- Travel-related health issues
- Parasite Biology and Host Interactions
- Toxoplasma gondii Research Studies
- Viral Infections and Vectors
- Global Maternal and Child Health
- Parasitic Diseases Research and Treatment
- Complement system in diseases
- Aquatic Ecosystems and Biodiversity
- Herpesvirus Infections and Treatments
- Iron Metabolism and Disorders
- Insect symbiosis and bacterial influences
- Hepatitis B Virus Studies
- Tryptophan and brain disorders
- Metabolomics and Mass Spectrometry Studies
- Digestive system and related health
- interferon and immune responses
- Parasitic Infections and Diagnostics
- Diverse Scientific Research Studies
- Moringa oleifera research and applications
- Insects and Parasite Interactions
National University of Malaysia
2014-2025
University Kebangsaan Malaysia Medical Centre
2017-2022
Universiti Malaysia Sarawak
2020-2021
Kasetsart University
2020-2021
National Institutes of Biotechnology Malaysia
2021
University of North Sumatra
2020
Karolinska Institutet
2014-2019
Universiti Sains Malaysia
2010-2012
University of Tübingen
2010
Abstract Kenya is intensifying its national efforts in malaria control to achieve elimination. Detailed characterization of infection among populations living the areas where disease endemic a crucial priority, especially for planning and evaluating future elimination strategy. This study aimed investigate distribution extent on islands Lake Victoria aid designing new interventions Five cross-sectional surveys were conducted between January 2012 August 2014 four (Mfangano, Takawiri, Kibuogi...
Introduction The incidence of malaria in Indonesia has declined significantly over the last few decades. Thus, a demand for more sensitive techniques to describe low levels transmission country is important. This study was conducted evaluate antibody response Plasmodium falciparum and vivax an area nearing elimination North Sumatera Province, Indonesia. Methods A cross-sectional survey Langkat district, June 2019. Basic demographic data filter paper blood spots were collected from 339...
Abstract Background Malaysia is on track towards malaria elimination. However, several cases of still occur in the country. Contributing factors and communal aspects have noteworthy effects any elimination activities. Thus, assessing community’s knowledge, attitudes practices (KAP) essential. This study was performed to evaluate KAP regarding among indigenous people (i.e. Orang Asli) Peninsular Malaysia. Methods A household-based cross-sectional conducted five remote villages (clusters) Asli...
Seroepidemiology can provide evidence for temporal changes in malaria transmission and is an important tool to evaluate the effectiveness of control interventions. During early 2000s, Vanuatu experienced acute increase incidence due a lapse funding vector control. After distribution subsidised insecticide-treated nets (ITNs) resumed 2003, decreased subsequent years. This study was conducted find serological supporting impact ITN on exposure Anopheles bites parasite prevalence.On Ambae...
As markers of exposure anti-malaria antibody responses can help characterise heterogeneity in malaria transmission. In the present study to Plasmodium falciparum AMA-1, MSP-119 and CSP were measured with aim describe transmission patterns meso-endemic settings Lake Victoria. Two cross-sectional surveys conducted Victoria January August 2012. The area comprised three settings: mainland (Ungoye), large island (Mfangano) small islands (Takawiri, Kibuogi, Ngodhe). Individuals provided a...
Naturally acquired antibodies to proteins expressed on the Plasmodium falciparum parasitized red blood cell (pRBC) surface steer course of a malaria infection by reducing sequestration and stimulating phagocytosis pRBC. Here we have studied selection representing three different parasite gene families employing well-characterized with severe phenotype (FCR3S1.2). The presence naturally antibodies, impact rosetting rate, reactivity opsonization for in relation groups ABO system were assessed...
Abstract Although WHO recommends mass drug administration (MDA) for malaria elimination, further evidence is required understanding the obstacles optimum implementation of MDA. Just before long rain in 2016, two rounds MDA with artemisinin/piperaquine (Artequick) and low-dose primaquine were conducted a 35-day interval entire population Ngodhe Island (~500 inhabitants) Lake Victoria, Kenya, which surrounded by areas moderate high transmission. With approximately 90% compliance, Plasmodium...
Rapid diagnosis of malaria using acridine orange (AO) staining and a light microscope with halogen lamp interference filter was deployed in some malaria-endemic countries. However, it has not been widely adopted because: (1) the weak as an excitation set-up did work well under unstable power supply; and, (2) samples frequently inconsistent. The replaced by low-cost, blue light-emitting diode (LED) lamp. Using reformulated AO solution, protocol revised to make use concentration gradient...
Malaria remains a public health problem in many parts of the world. In Malaysia, significant progress towards national elimination programme and effective disease notification on malaria has resulted zero indigenous human cases since 2018. However, country still needs to determine extent exposure transmission patterns, particularly high-risk populations. this study, serological method was used measure levels Plasmodium falciparum vivax among Orang Asli communities Kelantan, Peninsular...
Understanding the transmission and movement of Plasmodium parasites is crucial for malaria elimination prevention resurgence. Located at limit in Pacific, Vanuatu an ideal candidate programs due to low endemicity isolated nature its island setting. We analyzed variation merozoite surface protein 1 (msp1) circumsporozoite (csp) P. falciparum vivax populations examine patterns gene flow population structures among seven sites on five islands Vanuatu. Genetic diversity was general higher than...
Plasmodium falciparum SURFIN4.1 is a putative ligand expressed on the merozoite and likely infected red blood cell, whose gene was suggested to be under directional selection in eastern Kenyan population, but balancing Thai population. To understand this difference, surf 4.1 sequences of western P. isolates were analysed. Frameshift mutations copy number variation (CNV) also examined for parasites from Kenya Thailand. Positively significant departures neutral expectations detected region...
Urinary schistosomiasis is caused by the digenetic trematode Schistosoma haematobium, characterized accumulation of eggs in genitourinary tract. Cytotoxic T-lymphocyte antigen 4 (CTLA-4) can play an important role parasitic infection due to its major as a negative regulator T-cell activation and proliferation. This study was performed patients with healthy controls analyze allele genotype frequencies four CTLA-4 gene polymorphisms. The amplified using Taqman real-time polymerase chain...
While there has been a tremendous decline in malaria disease burden the remote parts of Malaysia, little is known about incidence its urban localities. This study aimed to analyze trends cases Kuala Lumpur, Malaysia. All suspected presented university hospital Lumpur from January 2005 December 2020 were examined by microscopy. Infection status was analyzed using descriptive statistics and curve estimation analysis. Of 3105 blood films examined, 92 (3%) microscopically confirmed cases....
Malaria remains a major public health challenge in Thailand. Continuous assessment and understanding of the behavior perceptions related to malaria exposure high-risk group are necessary achieve elimination goal. This study aimed investigate parasite prevalence, seroprevalence rate, knowledge, attitudes, practices (KAP), risk factors rural communities living close forested area northeastern part A community-based cross-sectional survey was conducted three forest-goer (i.e., Ban Khok, Koh,...
Toxoplasma gondii is an opportunistic protozoan parasite known to affect the human brain. The infection has been associated with increased incidence of schizophrenia; however, link between two conditions remains unclear. This study aimed compare plasma metabolome schizophrenia and non-schizophrenia subjects or without infection. Untargeted metabolomic profiling was carried out by liquid chromatography-mass spectrometry. Elevation α-hydroxyglutaric acid level reduced adenosine monophosphate,...
Indonesia is progressing towards malaria elimination. To achieve this goal, intervention measures must be addressed to cover all Plasmodium species. Comprehensive control and surveillance programmes intensified. This study aims determine the prevalence of microscopic submicroscopic in Langkat district, North Sumatera Province, Indonesia.A cross-sectional survey was conducted six villages Province June 2019. Data were recorded using a standardized questionnaire. Finger pricked blood samples...
Opisthorchiasis caused by Opisthorchis viverrini infection is a major public health concern in Thailand.Despite many decades of national campaigns place to reduce and control opisthorchiasis Thailand, the infections remain exist particularly northern northeastern parts country.This study aimed evaluate current prevalence O. rural communities northeast Thailand.A cross-sectional survey was conducted between February October 2018 three districts (Na Kae, That Phanom Wang Yang) Nakhon Province,...
SUMMARY Brugia malayi is one of the parasitic worms which causes lymphatic filariasis in humans. Its geographical distribution includes a large part Asia. Despite its wide distribution, very little known about genetic variation and molecular epidemiology this species. In study, internal transcribed spacer 1 (ITS1) nucleotide sequences B. from microfilaria-positive human blood samples Northeast Borneo Island were determined, compared with published ITS1 isolated cats humans Thailand. Multiple...