A5061604853- Hepatitis B Virus Studies
- Forensic and Genetic Research
- Hepatitis C virus research
- Molecular Biology Techniques and Applications
- Genetic diversity and population structure
- Cervical Cancer and HPV Research
- Sexual Differentiation and Disorders
- Race, Genetics, and Society
- SARS-CoV-2 and COVID-19 Research
- Genetic Associations and Epidemiology
- SARS-CoV-2 detection and testing
- COVID-19 Clinical Research Studies
- Protist diversity and phylogeny
- Animal Virus Infections Studies
- Polyomavirus and related diseases
- Plant Virus Research Studies
- Viral gastroenteritis research and epidemiology
- Carcinogens and Genotoxicity Assessment
- Genomic variations and chromosomal abnormalities
- Women's cancer prevention and management
- Growth Hormone and Insulin-like Growth Factors
- Science and Education Research
- HIV/AIDS drug development and treatment
- Genomics and Rare Diseases
- Blood groups and transfusion
Secretaria da Saúde
2017-2024
Fundação Estadual de Produção e Pesquisa em Saúde
2008-2019
Universidade Luterana do Brasil
2007-2014
Instituto de Pesquisas Jardim Botânico do Rio de Janeiro
2008-2011
Congenital adrenal hyperplasia (CAH) is an autosomal recessive disorder associated with inborn errors of steroid metabolism. 21-hydroxylase enzyme deficiency occurs in 90 to 95% all cases CAH, accumulation 17 hydroxyprogesterone (17-OHP). Early diagnosis CAH based on newborn screening possible before the development symptoms and allows proper treatment, correct sex assignment, reduced mortality rates. This study describes results obtained first year a public program state Rio Grande do Sul,...
The aim of the present study was to investigate association between HPV-DNA and micronucleus (MN) frequency in women with normal cervical cytology. A total 158 smears were analyzed cytologically. HPV genome amplified using GP5+/bioGP6+ consensus primers. high-risk types 16, 18, 31, 33, 39, 45 59 also investigated. Of samples, 20 (12.7%) 47 (29.7%) positive for MN, respectively. Evidence MN found 11 out (55%) samples 36 138 (26.1%) negative ones. presence significantly higher (p = 0.016). On...
Hepatitis C virus (HCV) isolates have been divided into six genotypes (1 to 6). The duration of hepatitis standard treatment is 48 weeks for patients infected with HCV genotype 1 vs 24 those 2 and 3. A total 1544 from chronic living in the southern Brazilian states Rio Grande do Sul (RS, n = 627) Santa Catarina (SC, 917) were genotyped by restriction fragment length polymorphism (RFLP) polymerase chain reaction (PCR) products. In RS, 338 (53.9%; 95% CI 50.0 - 57.8%), 34 (5.4%; 3.8 7.4%) and,...
The aim of this study was to evaluate the association between frequency micronuclei (MN) and cellular changes detected in conventional Papanicolaou test. One hundred seventy-four test smears with were examined. MN screening done cytopathological by counting 1,000 cervical cells a light microscope. frequencies significantly higher group compared control (p < 0.001). mean 0.95 ± 1.12 (mean SD) (n = 223), 2.98 1.20 individuals atypical squamous undetermined significance (ASC-US) 50), 4.04 1.45...
This study investigates the frequency of Torque teno virus (TTV) infection in 150 blood donors and 77 patients requiring haemodialysis southern Brazil. Plasma samples were screened for TTV DNA using polymerase chain reaction (PCR). The prevalences among 73.3% 68.8%, respectively. presence was correlated with age (p = 0.024). In patients, no association found between demographic parameters (age, sex education), duration or a history transfusion. is first to evaluate prevalence Brazilian haemodialysis.
To describe the results obtained in a neonatal screening program after its implementation and to assess clinical molecular profiles of confirmed suspicious congenital adrenal hyperplasia cases. A cross-sectional study was conducted. Newborns with suspected disease due high 17-hydroxyprogesterone levels adjusted for birth weight were selected. Classical (salt-wasting simple virilizing forms) diagnosed by an increase as retest, evaluation, genotype determined SNaPshot multiplex...
HPV types 16 and 18 were studied in paraffin-fixed cervical biopsy collected southern Brazil. 16, co-infection 16/18 identified 10/57 (17.5%), 4/57 (7%) 43/57 (75.4%) samples, respectively. Southern Brazil has one of the highest prevalence rates reported.
A single-nucleotide polymorphism (SNP) upstream of interleukin (IL)28B was recently identified as an important predictor the outcome chronic hepatitis C patients treated with pegylated interferon plus ribavirin (PEG-IFN/RBV). The aim this study to investigate association between IL28B gene (rs12979860) and virological response in patients. Brazilian (n = 263) who were infected virus (HCV) genotype 1 receiving PEG-IFN/RBV genotyped. Early (EVR) (12 weeks), end-of-treatment (EOTR) (48...
Certain host single nucleotide polymorphisms (SNPs) affect the likelihood of a sustained virological response (SVR) to treatment in subjects infected with hepatitis C virus (HCV). SNPs promoters interleukin (IL)-10 (-1082 A/G, rs1800896), myxovirus resistance protein 1 (-123 C/A, rs17000900 and -88 G/T, rs2071430) tumour necrosis factor (TNF) (-308 G/A, rs1800629 -238 rs361525) genes outcome PEGylated α-interferon plus ribavirin therapy were investigated. This analysis was performed 114...
Porto Alegre is the Brazilian state capital with second highest incidence of tuberculosis (TB) and proportion people infected human immunodeficiency virus (HIV) among patients TB. Hepatitis C (HCV) infection increases risk anti-TB drug-induced hepatotoxicity, which may result in discontinuation therapy.The aim this study was (i) to estimate prevalence HCV HIV a group newly diagnosed active TB public reference hospital (ii) compare demographic, behavioural, clinical characteristics relation...
Abstract Plasmodium vivax causes >70% of malaria cases in Latin America. The emergence simium , transmitted from humans to monkeys, increased the burden, notably after an outbreak 2015 Brazil. To investigate P. evolutionary history, we screened 646 monkey samples and analyzed whole genome variations for 19 408 isolates. strains were identified Colombian (n=3) Brazilian monkeys (n=1), suggesting host reinvasion Colombia genetic exchange between Genetic analysis indicates that originated a...
To describe the results obtained in a neonatal screening program after its implementation and to assess clinical molecular profiles of confirmed suspicious congenital adrenal hyperplasia cases. A cross-sectional study was conducted. Newborns with suspected disease due high 17-hydroxyprogesterone levels adjusted for birth weight were selected. Classical (salt-wasting simple virilizing forms) diagnosed by an increase as retest, evaluation, genotype determined SNaPshot multiplex...
This study describes a colorimetric method for detecting and genotyping hepatitis C virus (HCV) in which four different oligonucleotide probes are fixed onto microwell plates hybridized separately with biotinylated PCR amplification products derived from clinical samples. The first probe capable of hybridizing all seven known HCV genotypes was used overall detection, the remaining were to recognize specifically 1–3. When combined an improved silica-based RNA extraction method, sensitivity...
Abstract In 2019, a new coronavirus disease (COVID-19) was detected in China. Severe acute respiratory syndrome 2 (SARS-CoV-2) capable to infect domestic and captive mammals like cats, tigers minks. Due genetic similarities, concern about the infection of Non-Human Primates (NHPs) establishment sylvatic cycle has grown Americas. this study, neotropical primates (NP) were sampled different areas from Brazil investigate whether they infected by SARS-CoV-2. A total 89 samples 51 NP four species...