A5039337342- Colorectal Cancer Screening and Detection
- Pancreatic and Hepatic Oncology Research
- Gastric Cancer Management and Outcomes
- Pancreatitis Pathology and Treatment
- Colorectal Cancer Surgical Treatments
- Genetic factors in colorectal cancer
- Helicobacter pylori-related gastroenterology studies
- Gastroesophageal reflux and treatments
- Esophageal and GI Pathology
- Colorectal and Anal Carcinomas
- Esophageal Cancer Research and Treatment
- Eosinophilic Esophagitis
- Neuroendocrine Tumor Research Advances
- Cholangiocarcinoma and Gallbladder Cancer Studies
- COVID-19 and healthcare impacts
- Cancer, Lipids, and Metabolism
- Global Cancer Incidence and Screening
- Multiple and Secondary Primary Cancers
- Cancer, Stress, Anesthesia, and Immune Response
- Photodynamic Therapy Research Studies
- Medical research and treatments
- Veterinary medicine and infectious diseases
- Bioactive Compounds and Antitumor Agents
- Machine Learning in Healthcare
- Microscopic Colitis
VA San Diego Healthcare System
2016-2024
University of California, San Diego
2016-2024
Central Arkansas Veterans Healthcare System
2018
San Francisco VA Medical Center
2018
Myriad (Germany)
2018
AstraZeneca (Poland)
2018
Astellas Pharma (China)
2018
Boehringer Ingelheim (France)
2018
Exact Sciences (United States)
2018
Background & AimsColorectal cancer (CRC) incidence and mortality are increasing among persons younger than 50 years old in the United States, but risk factors associated with early-onset CRC (EOCRC) have not been widely studied.MethodsWe conducted a case-control study of US veterans 18 to 49 who underwent colonoscopy examinations from 1999 through 2014. EOCRC cases were identified national registry; free at their baseline 3 follow-up as controls. We collected data on age, sex,...
is the most common cause of infection-associated cancer worldwide. We aimed to evaluate impact H. pylori infection and treatment on colorectal (CRC) incidence mortality.
Objective To conduct an anatomic site-specific case–control study of candidate colorectal cancer (CRC) risk factors. Design Case–control US veterans with >1 colonoscopy during 1999–2011. Cases had registry-identified CRC at colonoscopy, while controls were free and within 3 years colonoscopy. Primary outcome was CRC, stratified by site: proximal, distal, or rectal. Candidate factors included age, sex, race/ethnicity, body mass index, height, diabetes, smoking status, aspirin exposure...
Cancer ascertainment using large-scale electronic health records is a challenge. Our aim was to propose and apply structured approach for evaluating multiple candidate approaches cancer colorectal (CRC) within the US Department of Veterans Affairs (VA) as use case.The proposed strategies includes assessment individual strategy performance, comparison agreement across strategies, review discordant diagnoses. We applied this compare three CRC VA: administrative claims data consisting...
INTRODUCTION: Achalasia is a postulated risk factor of esophageal cancer (EC); however, EC-associated in achalasia understudied. We aimed to evaluate EC among individuals within the nationwide Veterans Affairs Cohort. METHODS: conducted matched cohort study US veterans aged 18 years or older from 1999 2019. Individuals with were age and sex 1:4 without achalasia. Follow-up continued entry until diagnosis incident/fatal (primary outcome), death non–EC-related causes, end follow-up (December...
Background: Aspirin impacts risk for important outcomes such as cancer, cardiovascular disease, and gastrointestinal bleeding. However, ascertaining exposure to medications available both by prescription over-the-counter aspirin research quality improvement purposes is a challenge. Objectives: Develop validate strategy exposure, utilizing combination of structured unstructured data. Research Design: This retrospective cohort study. Subjects: In total, 1,869,439 Veterans who underwent usual...
INTRODUCTION: Metformin may be associated with reduced colorectal cancer (CRC) risk, but findings from previous studies have been inconsistent and had insufficient sample sizes to examine whether the association differs by anatomic site. This study examined metformin was CRC both overall stratified site, in a large of persons diabetes who underwent colonoscopy. METHODS: We performed case-control US Veterans prevalent colonoscopy between 1999 2014 using Department Affairs electronic health...
Postpolypectomy risk stratification for subsequent metachronous advanced neoplasia (MAN) is imprecise and does not account colonoscopist adenoma detection rate (ADR). Our aim was to assess association of ADR with MAN create a prediction model postpolypectomy incorporating other factors.We conducted retrospective cohort study individuals baseline polypectomy surveillance colonoscopy from 2004 2016 within the U.S. Department Veterans Affairs (VA). Clinical factors, polyp findings, were...
Standardized approaches for rigorous validation of phenotyping from large-scale electronic health record (EHR) data have not been widely reported. We proposed a methodologically and efficient approach to guide such validation, including strategies sampling cases controls, determining sample sizes, estimating algorithm performance, terminating the process, hereafter referred as San Diego Approach Variable Validation (SDAVV). propose size formulae which should be used prior chart review, based...
INTRODUCTION: Colorectal cancer (CRC) incidence and mortality rates are increasing in adults aged <50 years. Young-onset adenoma (YOA)—adenoma detected younger than 50 years—may signify increased CRC risk, but this association has not been widely studied. Our aim was to compare the risk of incident fatal years with YOA diagnosis compared those a normal colonoscopy. METHODS: We conducted cohort study US Veterans 18–49 who received colonoscopy between 2005 2016. The primary exposure...
Pancreatic cancer incidence and mortality among patients with pancreas cysts are unclear. The aims of this study to evaluate pancreatic cause-specific using a large national cohort over long follow-up period.We conducted retrospective US Veterans diagnosed cyst 1999-2013, based on International Classification Diseases, 9th edition (ICD9) coding within Department Affairs (VA) data. was ascertained VA registry data, ICD-9 codes, the National Death Index, centralized database death records,...
Objective: To describe a framework for leveraging big data research and quality improvement purposes demonstrate implementation of the design Department Veterans Affairs (VA) Colonoscopy Collaborative.Methods: We propose that utilizing large-scale electronic health records (EHRs) can be approached in 4 step framework: 1) Identify sources required to answer question; 2) Determine whether variables are available as structured or free-text data; 3) Utilize rigorous approach refine assess...
Background and AimsTraditional serrated adenomas (TSAs) may confer increased risk for colorectal cancer (CRC). Our objective with this study was to examine clinical characteristics long-term outcomes associated TSA diagnosis.MethodsWe conducted a retrospective cohort of U.S. Veterans ≥18 years age ≥1 between 1999 2018. Baseline characteristics, colonoscopy findings, diagnosis incident fatal CRC were abstracted. Advanced neoplasia defined by or adenoma high-grade dysplasia, villous histology,...
Background and AimsRisk factors for pancreatic cancer among patients with cysts are incompletely characterized. The primary aim of this study was to evaluate risk development cysts.MethodsWe conducted a retrospective case-control U.S. veterans suspected diagnosis branch-duct intraductal papillary mucinous neoplasm from 1999 2013.ResultsAge (hazard ratio [HR], 1.03 per year; 95% confidence interval [CI], 1.00-1.06), larger cyst size at (HR, mm; CI, 1.01-1.04), growth rate 1.22 mm/y;...
Delays in colonoscopy work-up for red flag signs or symptoms of colorectal cancer (CRC) during the COVID-19 pandemic are not well characterized. To examine uptake and time to after diagnosis, before pandemic. Cohort study adults ages 50–75 with iron deficiency anemia (IDA), hematochezia, abnormal stool blood test receiving Veterans Health Administration (VHA) care from April 2019 December 2020. Index date was first diagnosis date, categorized into "pre" (April–December 2019) "intra" 2020)...
There are limited contemporary population-based data on
Introduction: Pancreatic cysts are commonly seen, particularly with the growing use of abdominal imaging, a prevalence 2% to 15%. The primary concern for patients is risk present or future pancreatic cancer. However, incidence cancer among remains unclear due small study samples, reliance on surgical resection series and short follow-up in prior studies. aim this evaluate using large national cohort Veterans Affairs (VA) over long period. Methods: We conducted retrospective identifying adult...