A5053187517- Colorectal Cancer Screening and Detection
- Global Cancer Incidence and Screening
- Lung Cancer Diagnosis and Treatment
- Lung Cancer Treatments and Mutations
- Nutritional Studies and Diet
- Gastric Cancer Management and Outcomes
- Metabolism, Diabetes, and Cancer
- Cancer, Lipids, and Metabolism
- Economic and Financial Impacts of Cancer
- Nutrition and Health in Aging
- Genetic factors in colorectal cancer
- Cancer Risks and Factors
- Colorectal Cancer Surgical Treatments
- Lung Cancer Research Studies
- Advances in Oncology and Radiotherapy
- Health, psychology, and well-being
- Fibromyalgia and Chronic Fatigue Syndrome Research
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Frailty in Older Adults
- Colorectal and Anal Carcinomas
- Palliative Care and End-of-Life Issues
- Colorectal Cancer Treatments and Studies
- Health, Environment, Cognitive Aging
- Health Systems, Economic Evaluations, Quality of Life
- Head and Neck Cancer Studies
Durham VA Medical Center
2015-2024
Durham VA Health Care System
2017-2024
Duke University
2010-2024
Duke Medical Center
2014-2023
Women's College Hospital
2021-2022
Duke University Health System
2021
University Health Care System
2021
Duke Cancer Institute
2020
Christ University
2018
Williams (United States)
2018
Background & AimsColorectal cancer (CRC) incidence and mortality are increasing among persons younger than 50 years old in the United States, but risk factors associated with early-onset CRC (EOCRC) have not been widely studied.MethodsWe conducted a case-control study of US veterans 18 to 49 who underwent colonoscopy examinations from 1999 through 2014. EOCRC cases were identified national registry; free at their baseline 3 follow-up as controls. We collected data on age, sex,...
The optimal chemotherapy regimen to use with radiotherapy in stage III non-small-cell lung cancer is unknown. Here, we compare the outcome of patents treated within Veterans Health Administration either etoposide-cisplatin (EP) or carboplatin-paclitaxel (CP).We identified patients EP and CP concurrent from 2001 2010. Survival rates were compared using Cox proportional hazards regression models adjustments for confounding provided by propensity score methods an instrumental variables...
Introduction: Nearly 50,000 incident cancer cases are reported in Veterans Affairs (VA) Central Cancer Registry (VACCR) annually. This article provides an updated report of incidence recorded VACCR. Materials and Methods: Data were obtained from VACCR for cancers diagnosed the VA health care system, focusing on 2010 data. among patients is described by anatomical site, sex, race, stage, geographic location, was compared to general U.S. population. Results: In 2010, 46,170 invasive cancers,...
Abstract Background: Associations between individual foods and nutrients colorectal cancer have been inconsistent, few studies examined associations food, nutrients, dietary patterns, rectal cancer. We the relationship food groups patterns risk for in non-Hispanic Whites African-Americans. Methods: Data were from North Carolina Colon Cancer Study—Phase II included 1,520 (720 cases, 800 controls) 384 African-Americans (225 159 controls). Diet was assessed using History Questionnaire....
Objectives. We assessed cancer care disparities within the Veterans Affairs (VA) health system and whether between-hospital differences explained disparities. Methods. linked VA registry data with Medicare administrative examined 20 cancer-related quality measures among Black White veterans diagnosed colorectal (n = 12 897), lung 25 608), or prostate 38 202) from 2001 to 2004. used logistic regression assess racial for each measure hospital fixed-effects models determine were attributable...
IntroductionLung cancer survival is improving in the United States. We investigated whether there was a similar trend within Veterans Health Administration (VHA), largest integrated healthcare system States.MethodsData from Affairs Central Cancer Registry (VACCR) were analyzed for temporal trends using Kaplan-Meier (K-M) estimates and linear regression.Results54,922 identified with lung diagnosed 2010-2017. Histologies classified as non-small cell (NSCLC) (64.2%), small (SCLC) (12.9%),...
Studies have suggested that red and processed meat consumption elevate the risk of colon cancer; however, relationship between meat, as well fat protein, distal colorectal cancer (CRC) specifically is not clear. We determined CRC associated with fat, protein intakes in Whites African Americans. There were 945 cases (720 White, 225 American) 959 controls (800 159 American). assessed dietary intake previous 12 mo. Multivariate logistic regression analyses used to obtain odds ratios (OR) 95%...
BACKGROUND Despite clinical trials demonstrating improved survival with adjuvant chemotherapy (AC) for patients American Joint Committee on Cancer stages I to III non‐small cell lung cancer (NSCLC), it is unclear whether this benefit extends broader populations. The current study evaluated patterns of AC use and examined the impact survival. METHODS A retrospective analysis was conducted in Veterans Affairs Central Registry diagnosed IB IIIA NSCLC between 2001 2008. Descriptive statistics...
It is unclear why racial differences exist in the frequency of surgery for lung cancer treatment. Comorbidity an important consideration selection patients treatment, including surgery. To assess whether comorbidity contributes to observed differences, we evaluated prevalence and their impact on receipt surgery.A total 1,314 (1,135 white, 179 black) Veterans Health Administration diagnosed with early-stage non-small-cell 2007 were included. The effect was determined by using generalized...
Adjuvant chemotherapy after surgical resection improves outcomes for patients with early-stage non-small cell lung cancer (NSCLC). To the authors' knowledge, there are no published prospective trials to date of adjuvant administered exclusively in older patients. In current study, authors sought evaluate efficacy a Veterans Health Administration cohort.Patients who underwent American Joint Committee on Cancer stages IB III NSCLC between 2001 and 2011 were analyzed. Data regarding patient...
Metformin has been associated with improved colorectal cancer survival, but investigations are limited by small numbers of patients and confounding diabetic severity. We examined the association between metformin use overall survival (OS) in diabetes a large population U.S. veterans, while adjusting for measures severity.Patients diagnosed from January 2001 to December 2008 were identified Veterans Affairs Central Cancer Registry. Multivariable models used examine adjusted OS antidiabetic...
Cancer ascertainment using large-scale electronic health records is a challenge. Our aim was to propose and apply structured approach for evaluating multiple candidate approaches cancer colorectal (CRC) within the US Department of Veterans Affairs (VA) as use case.The proposed strategies includes assessment individual strategy performance, comparison agreement across strategies, review discordant diagnoses. We applied this compare three CRC VA: administrative claims data consisting...
Broken heart syndrome, otherwise known as takotsubo is stress-induced cardiomyopathy. Clinical presentation mimics acute ST segment elevation myocardial infarction, but with characteristic left ventricular apical ballooning. The mechanism linked to overstimulation of the sympathetic system from high circulating catecholamine levels. We report a 46-year-old Caucasian female whose treatment status asthmaticus ketamine and epinephrine precipitated this syndrome. She required hemodynamic support...
This data-based cohort consisted of 26,508 (7%) United States veterans out the 399,290 who tested positive for SARS-CoV-2 from 1 March to 10 September 2020. We aimed assess interaction post-index vitamin D (Vit D) and corticosteroid (CRT) use on 30-day mortality among hospitalized non-hospitalized patients with coronavirus disease 2019 (COVID-19). Combination Vit CRT drug was assessed according four multinomial pairs (-|+, -|-, +|+, +|-). Respective categorical effects were computed a...
Abstract Background: Risk for colorectal cancer (CRC) may accumulate through multiple environmental factors. Understanding their effects, along with genetics, age and family history, could allow improvements in clinical decisions screening protocols. We aimed to extend previous work by recalibrating an risk score (e-Score) CRC among a sample of US Veteran participants the Million Program (MVP). Methods: Demographic, lifestyle, data from 2011-2022 were abstracted survey responses health...
Recent reports of a potentially increased risk amyotrophic lateral sclerosis (ALS) for veterans deployed to the 1990-1991 Persian Gulf War prompted Department Veterans Affairs establish National Registry with ALS, charged goal enrolling all US neurologist-confirmed diagnosis ALS. The Genes and Environmental Exposures in ALS study (GENEVA) is case-control presently cases from registry representative sample veteran controls evaluate joint contributions genetic susceptibility environmental...