A5058997523- Cancer-related molecular mechanisms research
- Advances in Cucurbitaceae Research
- MicroRNA in disease regulation
- RNA Research and Splicing
- RNA modifications and cancer
- Nutrition and Health in Aging
- Plant Molecular Biology Research
- Plant Gene Expression Analysis
- Plant Virus Research Studies
- Photosynthetic Processes and Mechanisms
- Fatigue and fracture mechanics
- Bioinformatics and Genomic Networks
- High-Velocity Impact and Material Behavior
- Cardiovascular Function and Risk Factors
- Advanced MRI Techniques and Applications
- Chromosomal and Genetic Variations
- Plant Reproductive Biology
- IgG4-Related and Inflammatory Diseases
- Material Properties and Failure Mechanisms
- Gastrointestinal disorders and treatments
- S100 Proteins and Annexins
- Plant and Fungal Species Descriptions
- Acute Ischemic Stroke Management
- Sugarcane Cultivation and Processing
- RNA and protein synthesis mechanisms
Southern Medical University
2022-2025
Nanfang Hospital
2022-2025
Key Laboratory of Guangdong Province
2025
Northeast Agricultural University
2019-2024
Ministry of Agriculture and Rural Affairs
2020-2024
Dongzhimen Hospital Affiliated to Beijing University of Chinese Medicine
2023
Jiangyin People's Hospital
2022-2023
Southeast University
2022
Nantong University
2022
China University of Mining and Technology
2018-2019
Currently available microRNA (miRNA) target prediction algorithms require the presence of a conserved seed match to 5' end miRNA and limit sites 3' untranslated regions mRNAs. However, it has been noted that these requirements may be too stringent, leading substantial number missing targets. We have developed TargetS, novel computational approach for predicting targets with located along entire gene sequences, which permits finding additional are not in un-translated regions. Our model is...
This study aimed to investigate the relationship between visceral adipose tissue (VAT), measured using a body shape index (ABSI), and outcomes in patients with heart failure preserved ejection fraction (HFpEF). ABSI data cardiovascular were obtained from Treatment of Preserved Cardiac Function Heart Failure an Aldosterone Antagonist (TOPCAT) trial. was calculated waist circumference (WC), mass index, height. values categorized into tertiles for analysis (≤0.078, 0.078-0.084, > 0.084). In...
A high-density genetic map can provide a basis for quantitative trait locus (QTL) mapping and marker-assisted selection (MAS) based on single-nucleotide polymorphisms (SNPs). Specific length amplified fragment sequencing (SLAF-seq) has been successfully applied to construct maps of many species but not Cucurbita maxima. In this study, 100 F2 individuals from two morphologically diverse parents, namely "2013-12" "9-6", were used C. maxima using the SLAF-seq method. total 8,406 SLAF markers...
Sex expression is a complex process, and in-depth knowledge of its mechanism in pumpkin important. In this study, young shoot apices at the one-true-leaf stage 10-leaf Cucurbita maxima trimonoecious line ‘2013–12’ subandroecious ‘9–6’ were collected as materials, transcriptome sequencing was performed using an Illumina HiSeqTM 2000 System. 496 up-regulated genes 375 down-regulated identified between containing mostly male flower buds only female buds. Based on gene ontology (GO) Kyoto...
Clinically-informative biomarkers of ischemic stroke are needed for rapid diagnosis and timely treatment. In the present study, APOA1 unique peptide (APOA1-UP), a novel biomarker, was identified quantified by multiple reaction monitoring (MRM) using labeled reference (LRP). Serum samples 94 patients in group 37 non-stroke were analyzed levels total APOA1-UP, low density lipoprotein cholesterol (LDL-C), triglycerides (TG), high-density (HDL-C), (TC). Median ratio APOA1-UP/LRP 2.14...
Mesocarp color is an important agronomic trait of Cucurbita maxima and determined mainly by the contents compositions carotenoids. The two inbred lines with significant differences in fruit flesh were used study, orange '312-1' white '98-2'. Changes seven carotenoid produced '98-2' analyzed during development. expression eight key biosynthesis genes investigated five development stage lines. As intensified, was increased lutein, β-carotene zeaxanthin lack accumulation led to formation fruit....
RNA N6-methyladenosine (m6A) regulators are considered post-transcriptional that affect several biological functions, and their role in immunity, particular, is emerging. However, the of m6A respiratory allergic diseases remains unclear. Therefore, we aimed to investigate key mediating immune microenvironment infiltration characteristics.We downloaded gene expression profiles allergies from Gene Expression Omnibus (GEO) database performed hierarchical clustering, difference analysis,...
Abstract Motivation: MicroRNAs (miRNAs) play important roles in general biological processes and diseases pathogenesis. Identifying miRNA target genes is an essential step to fully understand the regulatory effects of miRNAs. Many computational methods based on sequence complementary rules mRNA expression profiles have been developed for this purpose. It noted that there many features targets available, including context sites, thermodynamic stability accessibility energy miRNA-mRNA...
Ethylene biosynthesis and signal transduction play critical roles in plant sex differentiation. ACS (1-aminocyclopropane-1-carboxylic acid synthase) is a rate-limiting enzyme ethylene biosynthesis. However, the understanding of gene family Cucurbita maxima limited. Here, we identified characterized 13 genes C. genome. All could be divided into three groups according to conserved serine residue at C-terminus. Thirteen CmaACS were found randomly distributed on 10 20 chromosomes maxima. The...
MicroRNAs (miRNAs) are small RNA molecules that play important roles in gene regulation and translational repression. The mechanisms facilitate miRNA target binding recognition have been extensively studied recent years. However, it is still not well known how the affected by location flanking sequences of sites. In this study, we systematically quantify contribution a wide spectrum sites on miRNA-mediated expression regulation. Our study investigates located four different regions,...
MicroRNAs (miRNAs) are small regulatory RNAs that play key gene-regulatory roles in diverse biological processes, particularly cancer development. Therefore, inferring miRNA targets is an essential step to fully understanding the functional properties of actions regulating tumorigenesis. Bayesian linear regression modeling has been proposed for identifying interactions between miRNAs and mRNAs on basis integrated sequence information matched mRNA expression data; however, this approach does...
Asthma is a heterogeneous disease, and the involvement of neurogenic inflammation crucial in its development. The standardized treatments focus on alleviating symptoms. Despite availability medications for asthma, they have proven to be inadequate controlling relapses halting progression disease. Therefore, there need novel drug targets prevent asthma.We utilized Mendelian randomization investigate potential asthma. We analyzed summary statistics from UK Biobank then replicated our findings...
The purpose of this study was to explore the role lncRNA MNX1-AS1 and its related downstream signaling pathways in colorectal adenocarcinoma (COAD). COAD tissues cells were prepared treated with sh-MNX1-AS1, pcDNA-MNX1-AS1, sh-PPFIA4, LY29004, their controls. CCK8 colony formation assays undertaken for evaluating cell proliferation. Tumor migratory ability detected by transwell assay. Apoptosis detection processed YO-PRO-1/PI Staining. regulated relationship between PPFIA4 confirmed RIP-ChIP...
The mottled leaf is one of the agronomic traits zucchini and can be applied as a marker trait in aggregation breeding. However, genetic mechanism responsible for has yet to elucidated. In present study, we used two inbred lines (line '19': silver leaf; line '113': normal leaf) parents physiological analysis leaf. synthesis net photosynthetic rate chlorophyll were not significantly affected areas leaves. detected large space between palisade parenchyma mottle area '19', which may have caused...
Trichomes provide an excellent model for studying cell differentiation and proliferation. The aboveground tissues of plants with long dense trichomes (LDTs) can cause skin itching in people working a zucchini field, which management, pollination, fruit harvesting are difficult. In this study, F 2 population was constructed the LDT inbred line “16” sparse micro trichome (SMT) “63” QTL analysis type I II density. Two QTLs were identified on chromosomes 3 15 using QTL-seq method. Additionally,...