A5021064225- Peripheral Nerve Disorders
- Orthopedic Surgery and Rehabilitation
- Congenital heart defects research
- Nerve Injury and Rehabilitation
- Shoulder Injury and Treatment
- Developmental Biology and Gene Regulation
- Shoulder and Clavicle Injuries
- Reconstructive Surgery and Microvascular Techniques
- Voice and Speech Disorders
- Tracheal and airway disorders
- Epigenetics and DNA Methylation
- Muscle Physiology and Disorders
- Vascular Procedures and Complications
- Foot and Ankle Surgery
- Lymphatic System and Diseases
- Tissue Engineering and Regenerative Medicine
- Genomics and Chromatin Dynamics
- Tendon Structure and Treatment
- Angiogenesis and VEGF in Cancer
- Telomeres, Telomerase, and Senescence
- Peripheral Artery Disease Management
- Vascular Malformations and Hemangiomas
- Lower Extremity Biomechanics and Pathologies
- Knee injuries and reconstruction techniques
- Facial Nerve Paralysis Treatment and Research
Universidad Complutense de Madrid
2011-2020
GTx (United States)
2013
Cancer Research UK
2009
King's College London
2006
University of Freiburg
2001-2006
Guy's Hospital
2006
Universitat Autònoma de Barcelona
1999-2003
Universitat de Barcelona
2002
Foro Italico University of Rome
2002
The INK4a/ARF tumor suppressor locus, a key executor of cellular senescence, is regulated by members the Polycomb group (PcG) transcriptional repressors. Here we show that signaling from oncogenic RAS overrides PcG-mediated repression INK4a activating H3K27 demethylase JMJD3 and down-regulating methyltransferase EZH2. In human fibroblasts, activates , but not ARF causes p16 -dependent arrest. mouse embryo Jmjd3 both Ink4a Arf elicits p53-dependent arrest, echoing effects in this system. Our...
A total of 112 human embryos (224 upper limbs) between stages 12 and 23 development were examined. It was observed that formation the arterial system in limb takes place as a dual process. An initial capillary plexus appears from dorsal aorta during stage develops at same rate limb. At 13, begins maturation process involving enlargement differentiation selected parts. This remodelling starts continues proximal to distal sequence. By 15 has reached subclavian axillary arteries, by 17 it...
Misexpression of Polycomb repressive complex 1 (PRC1) components in human cells profoundly influences the onset cellular senescence by modulating transcription INK4a tumor suppressor gene. Using tandem affinity purification, we find that CBX7 and CBX8, two (Pc) homologs repress INK4a, both participate PRC1-like complexes with at least Posterior sex combs (Psc) proteins, MEL18 BMI1. Each contains a single representative Pc Psc families. In primary fibroblasts, CBX7, BMI1 are present locus...
This study confirms that the median artery may persist in adult life 2 different patterns, palmar and antebrachial, based on their vascular territory. The type, which represents embryonic pattern, is large, long reaches palm. antebrachial a partial regression of slender, short, terminates before reaching wrist. These arterial patterns appear with incidence. pattern was studied whole sample (120 cadavers) had an incidence 20%, being more frequent females than males (1.3 1), occurring...
Based on a study of 70 human cadavers (31 male, 39 female) and cases described previously, we propose new classification the Martin-Gruber anastomosis, neural connection between median ulnar nerves in forearm. The anastomosis was found 16 (22.9%) cadavers, being bilateral three (18.7%) unilateral 13 (81.3%), five right eight left. It occurred (25.8%) 31 male (20.5%) females. Therefore, 19 (13.6%) 140 forearms. In Pattern I (89.5%) made by only one branch, whereas II (10.5%) it two....
Abstract Supernumerary humeral heads of the biceps brachii muscle were found in 27 (15.4%) 175 cadavers. They bilateral five cadavers and unilateral 22 (8 left, 14 right), giving a total 32 examples 350 arms (9.1%). Depending on their origin location, supernumerary classified as superior, infero‐medial, infero‐lateral heads. Previous studies reviewed using this classification. The infero‐medial head was observed 31 (9%) therefore most common variation. superior (1.5%). least variation, only...
Abstract The T‐box transcription factor Tbx1 has been implicated in DiGeorge syndrome, the most frequent syndrome due to a chromosomal deletion. Gene inactivation of mice results craniofacial and branchial arch defects, including myogenic defects first second arches. A binding site identified Xenopus Myf5 promoter, other species, genes have fate. Here we analyze expression developing chick embryo relating its onset differentiation cellular fate within mesoderm. We show that is expressed...
Abstract Background The aim of this work was to evaluate, prove their reliability, the different surgical landmarks previously proposed as a mean locate recurrent laryngeal nerve (RLN). Methods necks 143 (68 male and 76 female) human adult embalmed cadavers were examined. RLN origin length its relationship recorded results compared with those reported. Statistical comparisons performed using chi‐square test (significance, p ≤ .05). Results Mostly, is located anterior tracheoesophageal sulcus...
Polycomb group proteins form multicomponent complexes that are important for establishing lineage-specific patterns of gene expression. Mammalian cells encode multiple permutations the prototypic repressive complex 1 (PRC1) with little evidence functional specialization. An aim this study is to determine whether orthologs co-expressed in human fibroblasts act on different target genes and their genomic location changes during cellular senescence.Deep sequencing chromatin immunoprecipitated...
Abstract Recently, highly specific markers of the lymphatic endothelium have been found enabling us to reinvestigate embryonic origin lymphatics. Here we present a review our studies on development system in chick and quail embryos. We show that is derived from two sources: lymph sacs mesenchymal lymphangioblasts. Proliferation reveal BrdU‐labeling index 11.5% sac endothelial cells by day 6.25, which drops 3.5% 7. Lymphangioblasts are able integrate into lining sacs. Lymphatic express...
Abstract Objectives/Hypothesis: Current knowledge of the functional role human laryngeal nerves is based on traditional neuroanatomic descriptions or contradictory electromyographic studies. The aim this study was to clarify neural connections between by correlating different patterns observed after stimulation and existence connections. Study Design: Descriptive. Methods: Electromyographic morphologic in 13 patients during total laryngectomy procedure. Results: Seven showed an additional...
This study confirms that the median artery may persist in adult life 2 different patterns, palmar and antebrachial, based on their vascular territory. The type, which represents embryonic pattern, is large, long reaches palm. antebrachial a partial regression of slender, short, terminates before reaching wrist. These arterial patterns appear with incidence. pattern was studied whole sample (120 cadavers) had an incidence 20%, being more frequent females than males (1.3[ratio ]1), occurring...