A5027736495- Pancreatic and Hepatic Oncology Research
- CRISPR and Genetic Engineering
- Adenosine and Purinergic Signaling
- Ubiquitin and proteasome pathways
- Cancer Genomics and Diagnostics
- Glioma Diagnosis and Treatment
- Cancer Research and Treatments
Universitätsklinikum Erlangen
2019-2024
Friedrich-Alexander-Universität Erlangen-Nürnberg
2019-2024
In 90% of pancreatic ductal adenocarcinoma cases, genetic alteration the proto-oncogene Kras has occurred, leading to uncontrolled proliferation cancerous cells. Targeting proven be difficult and battle against cancer is ongoing. A promising approach combat was discovery clustered regularly interspaced short palindromic repeat (CRISPR)/CRISPR-associated (Cas) system, which can used genetically modify To assess potential a CRISPR/CRISPR-associated protein 9 (Cas9) method eliminate mutations...
Pancreatic cancer is a malignant tumor of the digestive system. It highly aggressive, easily metastasizes, and extremely difficult to treat. This study aimed analyze genes that might regulate pancreatic migration provide an essential basis for prognostic assessment individualized treatment. A CRISPR knockout library directed against 915 murine was transfected into TB 32047 cell line screen which gene loss promoted migration. Next-generation sequencing PinAPL.py- analysis performed identify...