A5087309529- Congenital heart defects research
- Cystic Fibrosis Research Advances
- Congenital Heart Disease Studies
- Neonatal Respiratory Health Research
- Advanced Radiotherapy Techniques
- Inhalation and Respiratory Drug Delivery
- Family Support in Illness
- Palliative Care and End-of-Life Issues
- Cancer survivorship and care
- Prostate Cancer Diagnosis and Treatment
- Genetic factors in colorectal cancer
- Ion channel regulation and function
- Respiratory Support and Mechanisms
- Skin and Cellular Biology Research
- MRI in cancer diagnosis
- Economic and Financial Impacts of Cancer
- Connexins and lens biology
- Radiomics and Machine Learning in Medical Imaging
- Heat shock proteins research
- Colorectal Cancer Treatments and Studies
- Management of metastatic bone disease
- Prostate Cancer Treatment and Research
- Medical Imaging Techniques and Applications
- Physiological and biochemical adaptations
- Cancer-related cognitive impairment studies
Gold Coast Hospital
2020-2024
Greenslopes Private Hospital
2024
Cancer Council Queensland
2024
Broad Center
2019-2020
University of California, San Francisco
2019-2020
Gold Coast Health
2020
Bond University
2020
The University of Queensland
1996-2001
Centre for Cellular and Molecular Biology
2000
Poole Hospital
1999-2000
Tissue regenerative potential displays striking divergence across phylogeny and ontogeny, but the underlying mechanisms remain enigmatic. Loss of mammalian cardiac correlates with cardiomyocyte cell-cycle arrest polyploidization as well development postnatal endothermy. We reveal that diploid abundance 41 species conforms to Kleiber's law-the ¾-power law scaling metabolism bodyweight-and inversely standard metabolic rate, body temperature, serum thyroxine level. Inactivation thyroid hormone...
Abstract The major cause of death in cystic fibrosis (CF) is chronic lung disease associated with persistent infection by the bacterium, Pseudomonas aeruginosa. S100A8, an S-100 calcium-binding protein chemotactic activity, constitutively expressed lungs and serum CF patients. Levels S100A8 mRNA were found to be three four times higher mice carrying G551D mutation transmembrane conductance regulator compared littermate controls. Intravenous injection bacterial LPS induced a greater extent...
To investigate the function of murine cystic fibrosis transmembrane conductance regulator (CFTR), a full‐length cDNA encoding wild‐type CFTR was assembled and stably expressed in Chinese hamster ovary (CHO) cells. Like human CFTR, formed Cl − channels that were regulated by cAMP‐dependent phosphorylation intracellular ATP. However, had reduced single‐channel decreased open probability ( P o ) compared with those CFTR. Analysis dwell time distributions single suggested caused both residence...
Several cystic fibrosis (CF) mouse models demonstrate an increased susceptibility to Pseudomonas aeruginosa lung infection, characterized by excessive inflammation and high rates of mortality. Here we developed a model chronic P. disease in mice homozygous for the murine CF transmembrane conductance regulator G551D mutation that provides excellent disease. After 3 days infection with mucoid entrapped agar beads, animals lost substantially more body weight than non-CF control were less able...
Abstract Introduction Stereotactic radiation therapy is a highly specialised technique which requires careful and structured implementation. As part of national stereotactic programme implementation, protocols were developed chart round was formed, strongly recommended attendance presentation all cases before treatment. Herein, we describe our experiences launching its importance in programme. Method rounds held via videoconference between July 2018 2019. Data collected included attendances,...
The aim of this study was to produce a patient-centred information strategy based on the results local survey cancer patients about they receive and their needs. An anonymous patient distributed at Dorset Cancer Centre, Poole Hospital, regional centre for Dorset, in South-west England. All attending Centre during 1 week September 1999 were asked complete questionnaire experience sources, receipt quality information, perception requirements. Two hundred eighty-two returned. Most respondents...
Abstract Introduction Palliative radiotherapy (PRT) is frequently used to treat symptoms of advanced cancer, however benefits are questionable when life expectancy limited. The 30‐day mortality rate after PRT a potential quality indicator, and results from recent meta‐analysis suggest benchmark 16% as an upper limit. In this population‐based study Queensland, Australia, we examined rates following factors associated with decreased expectancy. Methods Retrospective population data Queensland...
Abstract Introduction Neo‐adjuvant androgen deprivation therapy prior to radiotherapy (RT) causes shrinkage of the prostate gland, but changes in volume have never been mapped over time detail, nor associations between reduction and testosterone escape or prostate‐specific antigen (PSA) kinetics determined. Methods Fifty consecutive patients with cancer were treated 6 months triptorelin definitive RT. The gland was measured at outset every 6–7 weeks thereafter using MRI scans. volumes...
ABSTRACT Cardiomyocyte (CM) proliferative potential varies considerably across species. While lower vertebrates and neonatal mammals retain robust capacities for CM proliferation, adult mammalian CMs lose due to cell-cycle withdrawal polyploidization, failing mount a response regenerate lost after cardiac injury. The decline of murine occurs in the period when endocrine system undergoes drastic changes adaptation extrauterine life. We recently demonstrated that thyroid hormone (TH) signaling...
Background and purpose Breast cancer survivorship care will become increasingly important as advances in treatment continue to increase survival. This study was a benchmarking project for large metropolitan breast service. Methods Participants consisted of 130 women who were >1 year since diagnosis cancer, attending any Service outpatient clinic. They assessed demographic clinical characteristics completed series self-report questionnaires examining service satisfaction, benchmarks,...
The regenerative capacity of the heart varies drastically across animal kingdom. Certain species, such as zebrafish and newts, display a remarkable innate ability for regeneration. In contrast, regeneration in adult mammals is limited. Heart potential also during organismal development. For example, while neonatal mice can regenerate their hearts, this lost first week after birth. Understanding cardiac pathways will play critical role discovering therapeutic approaches to stimulate human...