A5007647967- Turtle Biology and Conservation
- Immunotherapy and Immune Responses
- Amphibian and Reptile Biology
- Species Distribution and Climate Change
- HIV Research and Treatment
- Immune Cell Function and Interaction
- vaccines and immunoinformatics approaches
- Paleontology and Evolutionary Biology
- Ichthyology and Marine Biology
- T-cell and B-cell Immunology
- Virus-based gene therapy research
- Herpesvirus Infections and Treatments
- Wildlife Ecology and Conservation
- Evolution and Paleontology Studies
- Ecology and Vegetation Dynamics Studies
- Viral-associated cancers and disorders
- Hepatitis B Virus Studies
- Venomous Animal Envenomation and Studies
- Monoclonal and Polyclonal Antibodies Research
- Invertebrate Taxonomy and Ecology
- Lymphoma Diagnosis and Treatment
- Virology and Viral Diseases
- Cystic Fibrosis Research Advances
- interferon and immune responses
- Animal Diversity and Health Studies
Charles Darwin University
2023-2024
Senckenberg Natural History Collections Dresden
2024
Institute of Zoology
2024
Universidade do Estado do Amazonas
2023
Universidade de São Paulo
2014-2021
Species360
2021
São Paulo Museum of Art
2018-2020
University of Leicester
2017
Australian National University
1999-2011
University of Canberra
1996-2011
We present a review and analysis of the conservation status International Union for Conservation Nature (IUCN) threat categories all 360 currently recognized species extant recently extinct turtles tortoises (Order Testudines). Our is based on 2018 IUCN Red List 251 listed species, augmented by provisional assessments Tortoise Freshwater Turtle Specialist Group (TFTSG) 109 unlisted freshwater turtles, as well re-assessments several outdated assessments. Of tortoises, this combined indicates...
Lists of species underpin many fields human endeavour, but there are currently no universally accepted principles for deciding which biological should be when alternative taxonomic treatments (and, by extension, scientific names applied to those species). As improvements in information technology make it easier communicate, access, and aggregate biodiversity information, is a need framework that helps taxonomists the users taxonomy decide taxa used society whilst continuing encourage...
Murine interferon‐inducible T cell alpha chemokine (I‐TAC) is a potent non‐ELR Cys‐X‐Cys (CXC) that predominantly attracts activated lymphocytes and binds to the receptor CXCR3. Using semiquantitative reverse transcription–polymerase chain reaction (RT–PCR) we analysed murine I‐TAC expression in two different progenitor dendritic (DC) lines, MTHC‐D2 JAWS II which were exposed various cytokines, Con A‐activated splenocytes from panel of knockout mice. Analysis DC lines A cultures demonstrated...
Development of CD8 alphabeta CTL epitope-based vaccines requires an effective strategy capable co-delivering large numbers epitopes. Here we describe a DNA plasmid encoding polyepitope or "polytope" protein, which contained multiple contiguous minimal murine Mice vaccinated with this made MHC-restricted responses to each the epitopes, and protective were demonstrated in recombinant vaccinia virus, influenza tumor challenge models. generated by polytope vaccination lasted for 1 yr, could be...
The epitopes recognized by CD8+ cytotoxic T lymphocytes (CTL) are generated from cytosolic proteins proteolytic processing. nature of the influences exerted sequences flanking CTL on these processing events remains controversial. Here we show that each epitope within an artificial polyepitope protein containing nine minimal in sequence was processed and presented to appropriate clones. Natural were thus not required direct class I In addition, unnatural other did interfere with ability every...
Aim: Analyse the effects of professional flash glucose monitoring system (FreeStyle Libre Pro™) on glycaemic control in insulin-treated type 2 diabetes. Methods: Primary (n = 17) and secondary care centres 5) randomised 148 diabetes patients into three groups: (A) self-monitoring blood 52), (B) two Pro sensor wears 46) or (C) four 50). endpoint was time range (glucose 3.9–10 mmol/L) within group C comparing baseline with days 172–187. Predefined endpoints included HbA1c, hypoglycaemia...
Development of epitope-based CD8 alpha beta CTL vaccines requires effective strategies for codelivery large numbers individual epitopes. We have designed an artificial "polyepitope" protein containing 10 contiguous minimal epitopes, which were restricted by five MHC alleles and derived from viruses, a parasite, tumor model. A recombinant vaccinia virus coding this was capable inducing MHC-restricted primary responses to all Mice immunized with showed protection against murine...
Development and expansion of high-avidity T cell populations may be important for the success immunization strategies against HIV other pathogens that have presented major problems vaccine development. We used tetrameric-MHC complexes ex vivo lytic assays to show 'prime-boost' with DNA vaccines recombinant poxvirus vectors generates high frequencies cytotoxic lymphocytes (CTL) recognize target cells expressing very low levels specific antigen. These persist at least 6 months representing...
There have been many substantial advances in our knowledge of Australasian freshwater turtle biodiversity the last three decades, but classification genera and species is dire need review. The proliferation names unpublished manuscripts taxonomic works published ephemeral (often privately printed) magazines, journals or books, without benefits peer review often with little justification scant diagnoses, which are not allowable nomenclatural actions under International Code Zoological...
Abstract Self-published taxon descriptions, bereft of a basis evidence, are long-standing problem in taxonomy. The derives part from the Principle Priority International Code Zoological Nomenclature, which forces use oldest available nomen irrespective scientific merit. This provides route to ‘immortality’ for unscrupulous individuals through mass-naming taxa without basis, phenomenon referred as taxonomic vandalism. Following flood unscientific namings, 2013 group concerned herpetologists...
The polymerase chain reaction (PCR) is paramount in nucleic acid amplification testing, and for many assays, the use of PCR or qPCR considered 'gold standard'. While instrumentation executing has advanced over last two decades, a growing interest point-of-need testing highlighted deficit that exists 'rapid PCR' systems. Here, we describe field-forward prototype instrument capable ultra-fast thermal cycling real-time DNA RNA. custom-designed, injection-molded microfluidic chips interface with...
In the present study, we have isolated CD4+ CTLs that recognize an epitope from EBV nuclear Ag 2 in association with two different HLA-DQ Ags, DQA1*0501/DQB1*0201 (DQ2) or DQA1*0501/DQB1*0301 (DQ7). Both HLA-DQ2 and HLA-DQ7 alleles displayed a similar efficiency endogenous exogenous presentation of this epitope. Since earlier studies shown EBV-associated malignancy, Burkitt's lymphoma (BL), escapes class I-restricted immune recognition by down-regulating expression peptide transporter genes,...
The EBV-encoded latent membrane proteins (LMP1 and LMP2), which are expressed in various EBV-associated malignancies have been proposed as a potential target for CTL-based therapy. However, the precursor frequency LMP-specific CTL is generally low, immunotherapy based on these antigens often compromised by poor immunogenicity threat from their oncogenic potential. Here we developed replication- incompetent adenoviral vaccine that encodes multiple HLA class I-restricted epitopes LMP1 LMP2...
ABSTRACT Further advances are required in understanding protection from AIDS by T-cell immunity. We analyzed a set of multigenic simian/human immunodeficiency virus (SHIV) DNA and fowlpox priming boosting vaccines for immunogenicity protective efficacy outbred pigtail macaques. The number vaccinations required, the effect vaccination alone, cytokine (gamma interferon) coexpression boost was also studied. A coordinated induction high levels broadly reactive CD4 CD8 immune responses induced...
Diagnosability is central to taxonomy as are type specimens which define taxa. New advances in technologies and the discovery of new informative traits must be matched with previous taxonomic decisions based on name-bearing specimens. Consequently, challenge sequencing highly degraded DNA from historical types becomes an inevitability resolve very many issues arising from, by modern standards, poor species descriptions leading difficulties assign names genetic clusters identified fresh...
The identity of Chelodina oblonga has been unclear because it variously defined to include populations snake-necked chelid turtle from the southwest Western Australia, across northern Cape York and southern New Guinea in its broadest conception, just part this range (northern Australia Guinea), or restricted corner narrowest conception. Uncertainty over type specimens added confusion. In paper, we review historical data on extent series oblonga, potential provenance, find evidence that...