A5033202341- Lymphoma Diagnosis and Treatment
- Occupational and environmental lung diseases
- Chronic Lymphocytic Leukemia Research
- Pleural and Pulmonary Diseases
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Autoimmune and Inflammatory Disorders Research
- CNS Lymphoma Diagnosis and Treatment
- Immune Cell Function and Interaction
- T-cell and Retrovirus Studies
- Eosinophilic Disorders and Syndromes
- Multiple Myeloma Research and Treatments
- Acute Myeloid Leukemia Research
- Viral-associated cancers and disorders
- Platelet Disorders and Treatments
- Calpain Protease Function and Regulation
- Lung Cancer Treatments and Mutations
- Blood groups and transfusion
- Medical Imaging and Pathology Studies
- Peptidase Inhibition and Analysis
- Parvovirus B19 Infection Studies
- Immunodeficiency and Autoimmune Disorders
- Occupational exposure and asthma
- Advanced Glycation End Products research
- Cell death mechanisms and regulation
- Myasthenia Gravis and Thymoma
Saiseikai Ibaraki Hospital
2021-2025
Hyogo University
2011-2024
Noguchi Hospital
2007-2016
Hyogo Prefectural Amagasaki General Medical Center
2016
King Saud University
2012
Hyogo Medical University
2011
Kyoto University
2006
Kitano Hospital
2000-2001
Malignant pleural mesothelioma (MPM) is an aggressive malignant tumor of mesothelial origin that shows a limited response to conventional chemotherapy and radiotherapy. Therefore, diagnosing MPM early very important. Some researchers have previously reported high-mobility group box 1 (HMGB1) was correlated with pulmonary fibrosis. involves the transformation cells, which originate from mesenchymal cells similar lung fibroblasts. Here, we investigated serum levels HMGB1 in patients compared...
Abstract Pulmonary fibrosis in humans can occur as a result of large number conditions. In idiopathic pulmonary (IPF), function becomes progressively compromised resulting high mortality rate. Currently there are no proven effective treatments for IPF. We have recently reported that IL-6 and TGF-β1 plays an important role proliferation differentiation lung fibroblasts, all-trans-retinoic acid (ATRA) prevented bleomycin-induced through the inhibition these cytokines. Thalidomide (Thal) has...
Rationale: Although radiotherapy is effective in treating lung cancers, resultant pulmonary injury the main obstacle. Pulmonary fibrosis characterized by progressive worsening function leading to high incidence of death. Currently, however, there has been little progress preventive and therapeutic strategies.Objectives: Previously, we reported that all-trans-retinoic acid (ATRA) reduced both irradiation-induced interleukin (IL)-6 production fibroblasts IL-6–dependent cell growth, also...
Liver fibrosis with any aetiology, induced by the transdifferentiation and proliferation of hepatic stellate cells (HSCs) to produce collagen, is characterized progressive worsening in liver function, leading a high incidence death. We have recently reported that all-trans-retinoic acid (ATRA) suppresses lung fibroblasts prevents radiation- or bleomycin-induced fibrosis.We examined impact ATRA on carbon tetrachloride (CCl(4))-induced fibrosis. performed histological examinations quantitative...
Although high-dose thoracic radiotherapy is an effective strategy for some malignancies including lung cancers and malignant lymphomas, it often causes complications of radiation fibrosis. To study the mechanism initiating tissue fibrosis, we investigated irradiation-induced cytokine production from human fibroblastic cells found that IL-6 was stimulated by irradiation. autocrine growth factor myeloma cells, retinoic acid reported to inhibit their growth. Thus evaluated effect all- trans...
Summary Pulmonary fibrosis is characterized by progressive worsening of pulmonary function leading to a high incidence death. Currently, however, there has been little progress in therapeutic strategies for fibrosis. There have several reports on cytokines being associated with lung fibrosis, including interleukin (IL)-6 and transforming growth factor (TGF)-β1. We reported recently that two substances (ATRA thalidomide) preventive effects inhibiting IL-6-dependent proliferation...
Diffuse malignant peritoneal mesothelioma (DMPM) is an aggressive tumor of mesothelial origin that shows a limited response to cytoreductive surgery along with intraperitoneal chemotherapy. Therefore, early diagnosis DMPM very important. Some researchers have previously reported high-mobility group box 1 (HMGB1) was correlated pulmonary fibrosis. involves the transformation cells, which originate from mesenchymal similar lung fibroblasts. Here, we investigated serum levels HMGB1 in patients...
Background: Malignant pleural mesothelioma (MPM) is an aggressive malignant tumor of mesothelial origin associated with asbestos exposure. MPM has a limited response to conventional chemotherapy and radiotherapy, so early diagnosis very important. This study investigated the effusion mesothelin levels in patients compared them those population non-malignant pleuritis or lung cancer involving effusion.
Malignant pleural mesothelioma (MPM) is an aggressive malignant tumor of mesothelial origin associated with asbestos exposure. MPM has a limited response to conventional chemotherapy and radiotherapy, thus early diagnosis extremely critical. CT scans have accuracy in the differentiation between benign disease. Several studies reported that 18-fluorodeoxyglucose (FDG) positron emission tomography (PET) plays important role assessment thoracic malignancy such as lung cancer. Here, we...
Background: Diffuse malignant peritoneal mesothelioma (DMPM) is an aggressive tumor of mesothelial origin that shows a limited response to cytoreductive surgery along with intraperitoneal chemotherapy. Therefore, diagnosing DMPM early very important. Reactive oxygen species play important role in asbestos toxicity, which associated the pathogenesis growth. Thioredoxin-1 (TRX) small redox-active protein demonstrates antioxidative activity Here, we investigated serum levels TRX patients and...
Malignant pleural mesothelioma (MPM) is an aggressive malignant tumour of mesothelial origin associated with asbestos exposure. Because MPM has limited response to conventional chemotherapy and radiotherapy, the prognosis very poor. Several researchers have reported that cytokines such as interleukin (IL)-6 play important role in growth MPM. Previously, it was all- trans -retinoic acid (ATRA) inhibited production function IL-6 transforming factor (TGF)-β1 experiments using lung fibroblasts....
Malignant pleural mesothelioma (MPM) is an aggressive malignant tumour associated with asbestos exposure that has only a limited response to conventional therapy; therefore, diagnosing MPM early very important. We have previously reported angiopoietin (Ang)-1 was correlated bleomycin-induced pulmonary fibrosis. Here, we investigated the association of Ang-1 development cells, which originate from mesenchymal cells similar lung fibroblasts, and demonstrated stimulated growth migration in...
Malignant pleural mesothelioma (MPM), an asbestos-related aggressive malignant tumor of mesothelial origin, shows limited response to therapy and overall survival remains very poor. Reactive oxygen species play important role in asbestos toxicity. Here, we found that the patients with MPM had significantly higher serum levels thioredoxin-1 (TRX) than control population. The advanced-stage showed TRX those early-stage MPM. difference between groups lower was significant. Our data suggest...