A5034449838- Nanoparticle-Based Drug Delivery
- Chemical Reaction Mechanisms
- Characterization and Applications of Magnetic Nanoparticles
- Magnetic and Electromagnetic Effects
- Organophosphorus compounds synthesis
- Microfluidic and Bio-sensing Technologies
- Gold and Silver Nanoparticles Synthesis and Applications
- Electromagnetic Fields and Biological Effects
- Phosphorus compounds and reactions
- Laser-Ablation Synthesis of Nanoparticles
- Nanoplatforms for cancer theranostics
- Aerogels and thermal insulation
- Enzyme Structure and Function
- Biofield Effects and Biophysics
- Synthesis and Reactivity of Sulfur-Containing Compounds
- Quantum Dots Synthesis And Properties
- Iron oxide chemistry and applications
- Magnetic properties of thin films
- Transition Metal Oxide Nanomaterials
- Microfluidic and Capillary Electrophoresis Applications
- Chemical and Physical Studies
- Proteins in Food Systems
- Nanoparticles: synthesis and applications
- Catalysis and Oxidation Reactions
- Photosynthetic Processes and Mechanisms
Eindhoven University of Technology
2022-2025
Technical University of Munich
2019-2025
Helmholtz Zentrum München
2019-2025
Lomonosov Moscow State University
2013-2024
National University of Science and Technology
2018-2022
Ada Technologies (United States)
2022
National University of Science and Technology
2021
Pirogov Russian National Research Medical University
2020
University of Nebraska Medical Center
2013
Tambov State University
2013
High-quality, 25 nm octahedral-shaped Fe
Iron oxide nanoparticles have attracted a great deal of research interest and been widely used in bioscience clinical including as contrast agents for magnetic resonance imaging, hyperthermia field assisted radionuclide therapy. It is therefore important to develop methods, which can provide high-throughput screening biological responses that predict toxicity. The use nanoelectrodes single cell analysis play vital role this process by providing relatively fast, comprehensive, cost-effective...
Deactivation and structural deformation of enzymes immobilized on magnetic nanoparticles (MNPs) are observed after exposure to fields. These changes due realignment MNPs in response the AC field, which leads stresses MNP-linked polymer chains. Such translated an enzyme molecule a MNP aggregate induce deformations irreversible (or long lasting) conformational changes.
Multicolored gene reporters for light microscopy are indispensable biomedical research, but equivalent genetic tools electron (EM) still rare despite the increasing importance of nanometer resolution reverse engineering molecular machinery and reliable mapping cellular circuits. We here introduce fully encapsulin/cargo system Quasibacillus thermotolerans (Qt), which in combination with recently characterized encapsulin from Myxococcus xanthus (Mx) enables multiplexed reporter imaging via...
Magnetomechanical modulation of biochemical processes is a promising instrument for bioengineering and nanomedicine. This work demonstrates two approaches to control activity an enzyme, α-chymotrypsin immobilized on the surface gold-coated magnetite magnetic nanoparticles (GM-MNPs) using nonheating low-frequency field (LF MF). The measurement enzyme reaction rate was carried out in situ during exposure field. first approach involves α-chymotrypsin-GM-MNPs conjugates, which undergoes...
Heterodimeric nanoparticles comprising materials with different functionalities are of great interest for fundamental research and biomedical/industrial applications. In this work, Fe3O4-Au nano-heterostructures were synthesized by a one-step thermal decomposition method. The hybrid comprise highly crystalline 12 nm magnetite octahedron decorated single noble metal sphere 6 diameter. Detailed analysis the was performed UV-visible spectroscopy, magnetometry, calorimetry relaxometry studies....
Abstract Magnetic nanoparticles have proven invaluable for biomechanical investigations due to their ability exert localized forces. However, cellular delivery of exogenous magnetic agents often results in endosomal entrapment, thereby limiting utility manipulating subcellular structures. This study characterizes and exploits fully genetically controlled biomineralization iron‐oxide cores inside encapsulin nanocompartments enable magnetic‐activated cell sorting (MACS) manipulation. The...
Particles with high anisotropy in their magnetic properties and shape are of increasing interest for mechanobiology, where transducing a remotely applied field vector to local mechanical response is crucial. An outstanding challenge quantifying the torque single nanoparticle, typically range atto- femto-Newton-meters (Nm). The magneto-mechanical manifests due misalignment external built-in axis, as opposed force, complicates measurement scheme. In this work, we developed method using...
Size-selected Fe 3 O 4 –Au hybrid nanoparticles with diameters of 6–44 nm (Fe ) and 3–11 (Au) were prepared by high temperature, wet chemical synthesis. High-quality nanocrystals bulk-like magnetic behavior obtained as confirmed the presence Verwey transition. The 25 diameter nanomaterial sample (in aqueous agarose phantom systems) showed best characteristics for application contrast agents in resonance imaging local heating using particle hyperthermia. Due to octahedral shape large...
Over the past decade, cell therapy has found many applications in treatment of different diseases. Some cells already used clinical practice include stem and CAR-T cells. Compared with traditional drugs, living are much more complicated systems that must be strictly controlled to avoid undesirable migration, differentiation, or proliferation. One approaches prevent such side effects involves monitoring distribution human body by any noninvasive technique, as magnetic resonance imaging (MRI)....
Enzymes conjugated to magnetic nanoparticles (MNPs) undergo changes in the catalytic activity of non-heating low-frequency field (LFMF). We apply silico simulations by molecular dynamics (MD) and vitro spectroscopic analysis enzyme kinetics secondary structure study α-chymotrypsin (CT) gold-coated iron oxide MNPs. The latter are functionalized either carboxylic or amino group moieties vary points attachment. MD simulation suggests that application stretching force CT globule its groups...
Magnetite–gold dumbbell nanoparticles are essential for biomedical applications due to the presence of two surfaces with different chemical natures and potential combination magnetic plasmonic properties. Here, remote actuation Fe3O4-Au hybrid particles in a rotating (1 Hz, 7 mT), static (7 mT) or pulsed low-frequency (31 175 mT, 30 s pulse/30 pause) field was studied. The were synthesized by high-temperature wet chemistry protocol exhibited superparamagnetic properties saturation...
The demand for hybrid microelectronic systems has arisen because of the trend toward miniaturization devices, in particular lab-on-a-chip devices biomedicine. This paper aims to describe development microelectromagnetic structures manipulation biological cells. An innovative, low-cost, and highly practical approach based on use parallel conductive wires is described. types connection their effect magnetic field shape were investigated with simulations. strategy estimate required...
The study of growth and possible metastasis in animal models tumors would benefit from reliable cell labels for noninvasive whole-organism imaging techniques such as magnetic resonance imaging. Genetically encoded cell-tracking reporters have the advantage that they are contrast-selective viable cells with intact protein expression machinery. Besides, these do not suffer dilution during division. Encapsulins, which bacterial nanocompartments, can serve genetically controlled multimodal...
Desaktiviert und deformiert werden Enzyme, die auf magnetischen Nanopartikeln (MNPs) immobilisiert sind, beim Anlegen von Feldern. Diese Veränderungen resultieren aus der erneuten Ausrichtung MNPs im AC-Magnetfeld, mit den verknüpfte Polymerketten unter Belastung setzt. Für immobilisierte Enzymmoleküle einem MNP-Aggregat ergeben sich dadurch Deformationen irreversible (oder lange anhaltende) Konformationsänderungen.
Solid solution AuFe nanoparticles with paramagnetic Fe atoms in the Au matrix synthesized at 25 °C transform into Janus particles upon annealing 700 ferromagnetic bcc phase epitaxially grown on fcc Au.