A5039660325- Heart Rate Variability and Autonomic Control
- Blood Pressure and Hypertension Studies
- COVID-19 Clinical Research Studies
- Cardiovascular and exercise physiology
- Cardiovascular Effects of Exercise
- Neurological Disorders and Treatments
- Cardiovascular Disease and Adiposity
- Healthcare Systems and Public Health
- Lipoproteins and Cardiovascular Health
- Long-Term Effects of COVID-19
- Antiplatelet Therapy and Cardiovascular Diseases
- Cardiovascular Function and Risk Factors
- Heart Failure Treatment and Management
- Atrial Fibrillation Management and Outcomes
- Cardiovascular Syncope and Autonomic Disorders
- Chemical and Physical Studies
- Renin-Angiotensin System Studies
- Cardiovascular Issues in Pregnancy
- Paraoxonase enzyme and polymorphisms
- Gastrointestinal motility and disorders
- Diabetes Treatment and Management
- Herbal Medicine Research Studies
- Patient Satisfaction in Healthcare
- Nutrition, Genetics, and Disease
- Venous Thromboembolism Diagnosis and Management
Saratov State Medical University
2015-2025
Ministry of Health of the Russian Federation
2017-2024
Saratov Research Institute of Traumatology and Orthopedics
2024
Stanford University
2016
Bridgepoint (United Kingdom)
2013
Federal Agency for Health and Social Development
2007
Aim: A growing body of research suggests that acute myocardial infarction (AMI) may be an independent risk factor for cognitive impairment in patients with cardiovascular disease. The role premature ventricular contractions (PVCs) or atrial (PACs) occurring during the day has not been fully explored this patient population. objective study was to investigate clinical and functional relationships between functions severity daytime cardiac contractions, as well echocardiographic parameters...
Once a patient has been diagnosed with severe COVID-19 pneumonia, treatment options have limited effectiveness. Opaganib is an oral under investigation being evaluated for of hospitalized patients pneumonia. A randomized, placebo-controlled, double-blind phase 2/3 trial was conducted in 57 sites worldwide from August 2020 to July 2021. Patients received either opaganib (n = 230; 500 mg twice daily) or matching placebo 233) 14 days. The primary outcome the proportion no longer requiring...
Aim. To evaluate the interrelationship between diurnal changes in thyrotropic hormone (TTH), free triiodothyronine (FT3), and clinical features of IHD combination with AH atrial fibrillation (AF). Materials methods. Levels TTH, FT3, plasma cortisol were measured 133 patients or without paroxysmal AF. The studied indexes included duration IHD, AH, AF; presence absence AF AH; incidence rate episodes per week; severity exertional angina; systolic diastolic BP; EchoCG data. Results. Morning...
A new dosage form of lappaconitine hydrobromide has been created – the long-acting drug Allaforte®, which fewer side effects compared to traditional (Allapinin®). Objective. To evaluate effectiveness, safety and tolerability Allaforte® therapy in comparison with Rytmonorm® patients paroxysmal atrial fibrillation (AF). Material methods. Patients who met inclusion criteria those did not meet non-inclusion were randomized into 2 groups: 1st (n=50) received 25 mg 3 times a day an increase dose...
The genetic architecture of blood pressure (BP) includes more than 30 genes, the polymorphic variants which cause phenotypic heterogeneity BP. Given that a human information is largely stable from birth, it can act as an early predictor hypertension (HTN). Identification genes associated with high HTN risk may be one promising areas diagnosis and prevention this disease. In addition, availability data will make possible to clarify prognosis patients already HTN, well personalize treatment...
To compare the efficacy and safety of ketoprofen plasters diclofenac after 3 weeks administration in patients with osteoarthritis-related knee pain.This multicenter, randomized, active-controlled, open-label, parallel-group, noninferiority phase III study randomized 236 adults pain for plaster 30 mg twice daily (n = 118) or 15 once 118). The primary end point was mean change from baseline to week intensity score during walking, as measured by a 100-mm visual analog scale predefined margin...
Aim. To study the interrelation of polymorphic gene variants playing role in atherosclerosis development, with cognition disorders, central nervous system condition and chronic heart failure (CHF) course specifics patients ischemic disease. Material methods. 40 CHF I-IV functional class (NYHA) origin underwent testing, nuclear-magnetic resonance tomography brain, duplex brachiocephalic arteries scanning, APOC3, ABCA1 и PON1 polymorphism assessment, lipid, homocystein, brain natriuretic...
ABSTRACT Rationale There are few treatment options for severe COVID-19 pneumonia. Opaganib is an oral under investigation. Objective Evaluate opaganib in hospitalized patients with Methods A randomized, placebo-controlled, double-blind phase 2/3 trial was conducted 60 sites worldwide from August 2020 to July 2021. Patients received either (n=230; 500mg twice daily) or matching placebo (n=233) 14 days. Main Outcome Measurements Primary outcome the proportion of no longer requiring...
Саратовский ГМУ имени В
Aim: Although the prevalence of coronary heart disease (CHD) and hypertension which are most common causes development progression chronic failure (CHF) is high, 24-hour ambulatory blood pressure (BP) monitoring (ABPM) in patients with CHF not mandatory to be performed. The growing number evidence suggests that excessive decrease BP clearly reflects increased variability (BPV) affects survival (HF). objective study was investigate relationship between parameters specific severity features...
Background: Hyaluronan is an emerging target for COVID-19 and lung fibrosis. In open-label study the hyaluronidase bovhyaluronidase azoximer (BA) was associated with improved pulmonary function exercise tolerance in patients sequelae of COVID-19. this randomized, double-blind, placebo-controlled trial we evaluated effect BA on up to 12 months after COVID-19, characterized by reduced function, dyspnea, decreased oxygen saturation. Methods: Patients (n=392) were randomized 1:1 receive (3000U)...
The article discusses the results of a comparative phase III clinical trial efficacy and safety biosimilar Complarate (CPR; JSC Generium, Russia) reference drug Actemra (ACT; F. Hoffmann-La Roche Ltd., Switzerland) to assess their equivalence in patients with rheumatoid arthritis, RA (NCT06475508 clinicaltrials.gov). Materials methods. Male female aged 18–75 years moderate high disease activity insufficient response methotrexate (MTX) monotherapy and/or poor tolerability MTX or intolerance...
Aim. To assess the relation of polymorphism genes APOC3, PON1, AGT, AGTR1 and psychovegetative disorders in young, relatively healthy persons. Material methods. Totally, 75 volunteers included, white race, aged 20-25 y.o. Psychovegetative status was assessed with tests for panic attacks revealing, anxiety level assessment, as questionnaire vegetovascular dystony. The inclusion criteria organic pathology cardiovascular central nervous system. Genes identified method pyrosequencing...
Practitioners are often faced with a combination of coronary heart disease (CHD), chronic failure (CHF), and anaemic syndrome. These patients typically characterised by worse prognosis acute CHD, as well rapid progression CHF renal (CKF). This review is focussed on the epidemiology anaemia in CHD patients; aetiology pathogenesis CHF; changes cardiovascular parameters Despite abundance studies clinical course syndrome, very little known about effects treatment CHD. The presents external...
This review considers the risk factors for arterial hypertension (AH) progression, obstructive sleep apnea syndrome (OSAS) and novel coronavirus infection (COVID-19) as potential variables prognostic models of estimating probability destabilization mentioned conditions. The most published studies consider AH OSAS influencing course COVID-19, while moderate mild COVID-19 can be destabilizing factor regarding to OSAS. In addition, are interrelated with quality. worsening quality often both a...
Physical activity is a generally accepted means of primary and secondary prevention cardiovascular diseases, but in some cases, it can be risk factor for events, including sudden cardiac death (SCD). Most studies analyze the relationship events with volume general directions exercise. Besides, significant part guidelines are devoted to effects aerobic exercise, while importance anaerobic exercise remains controversial. The review analyzes works influence strength training, such as...
The aim of the study was to examine dependence functional and morphological changes in brain factors severity chronic heart failure. Materials methods: 54 patients with failure ischemic genesis, I-IV class were cognitive tests, echocardiography, nuclear magnetic resonance imaging brain. Results. With an increase failure, worst results Veksler-5 7 subtests are noted, a smaller thickness gray matter parietal lobes, lower diffusion coefficients water molecules white occipital middle legs...
Aim. To analyze the changes of systemic arterial pressure (BP) before and after sport load, incl. diagnosis hypertension (AH) antihypertensive treatment, in veteran sportsmen. Material methods. Questionnaires were applied for main cardiovascular risk factors assessment, BP measurement upright resting (before warming up exercises) just load 108 competitive sportsmen 40-72 y.o. In study, previously set was taken consideration its treatment type. Results. Among all participants, 41% had...
Urogenital form of autonomous diabetic polyneuropathy is a specific lesion the autonomic nervous system in patients with diabetes mellitus (DM) and main pathogenetic cause sexual dysfunction these patients. The most common DM an erectile dysfunction, risk which at 3 times higher for compared to population without it. Considering that are special group because presence complications, preferences therapy given inhibitors PDE-5 type inhibitors. Aim - optimization diagnosis treatment neurogenic...
Aim. To study the differences in views on treatment among patients with cardiovascular diseases state and private outpatient clinics, as well motivation for choosing one of these clinics. Material methods. Anonymous voluntary survey cardiology (n=90) 2 (57.7%) 3 clinics (42.2%) was conducted Saratov. Results. 33.3% respondents were men; median age 65 years. Patients more likely to have retirement (p=0.0008), low income (p=0.0006), history hypertensive crises (p=0.0129) chronic heart failure...
Abstract Funding Acknowledgements Type of funding sources: None. Background. Many patients with COVID-19 suffer from arterial hypertension and have marked variations in blood pressure (BP) during the acute period infection. The reasons for such changes are poorly understood. Purpose. To assess relationship between level BP severity main clinical laboratory parameters a moderate course at stage height disease. Materials methods. study included 86 hospitalized verified coronavirus disease...