A5101729625- HIV/AIDS Research and Interventions
- HIV Research and Treatment
- HIV/AIDS drug development and treatment
- HIV, Drug Use, Sexual Risk
- HIV-related health complications and treatments
- Adolescent Sexual and Reproductive Health
- Clinical practice guidelines implementation
- Childhood Cancer Survivors' Quality of Life
- COVID-19 epidemiological studies
- Mycobacterium research and diagnosis
- Biosimilars and Bioanalytical Methods
- Viral Infections and Vectors
- Health Promotion and Cardiovascular Prevention
- COVID-19 Clinical Research Studies
- Economic and Financial Impacts of Cancer
- Tuberculosis Research and Epidemiology
- Healthcare Policy and Management
- Cardiovascular Health and Risk Factors
- COVID-19 and healthcare impacts
- Human Rights and Development
- Pharmacological Effects and Toxicity Studies
- Sex work and related issues
- HIV/AIDS oral health manifestations
- Pneumocystis jirovecii pneumonia detection and treatment
Centers for Disease Control and Prevention
2008-2023
Chinese Center For Disease Control and Prevention
2012-2021
National Center for HIV/AIDS Viral Hepatitis STD and TB Prevention
2008-2021
State Key Laboratory of Virology
2018
Wuhan Institute of Virology
2018
Wuhan University
2018
Yunnan Center for Disease Control And Prevention
2012-2017
Center for Disease Control
2013-2015
Yunnan Institute For Drug Abuse
2012
Bio-Medical Science (South Korea)
2008
In the absence of an effective vaccine, HIV continues to spread globally, emphasizing need for novel strategies limit its transmission. Pre-exposure prophylaxis (PrEP) with antiretroviral drugs could prove be intervention strategy if highly efficacious and cost-effective PrEP modalities are identified. We evaluated daily intermittent regimens increasing antiviral activity in a macaque model that closely resembles human
Serodiagnosis of human immunodeficiency virus (HIV) infection in the United States has traditionally relied on a sequential two-test algorithm: an initial screen with enzyme immunoassay (EIA) and reflex testing EIA-reactive specimens more specific supplemental test such as Western blotting or immunofluorescence. The tests are tedious, subjective, expensive. In addition, there have been major improvements performance accuracy EIA well introduction rapid serologic (RT) HIV nucleic acid...
We demonstrate that integration of laboratory, phylogenetic, and epidemiologic data sources allow detailed reconstruction an outbreak. High-resolution outbreak phylodynamics allows prevention intervention strategies to be tailored community needs.
To investigate the prevalence and associated risk factors of human immunodeficiency virus (HIV), hepatitis B (HBV) sexually transmitted infections (STIs) among men who have sex with (MSM) in Kunming, 300 MSM were recruited through community-based organizations between September 2014 January 2015. The HIV, HBsAg, syphilis, Chlamydia trachomatis (CT) Neisseria gonorrhoeae (NG) 17.0%, 7.7%, 11.3%, 18.2% 13.2%, respectively. In three different anatomic sites (urethra, rectum pharynx), rectal CT...
Abstract Background Knowledge of COVID-19 epidemiology remains incomplete and crucial questions persist. We aimed to examine risk factors for death. Methods A total 80 543 cases reported in China, nationwide, through 8 April 2020 were included. Risk death investigated by Cox proportional hazards regression stratified analyses. Results Overall national case-fatality ratio (CFR) was 5.64%. older age (≥80: adjusted hazard ratio, 12.58; 95% confidence interval, 6.78–23.33), presence underlying...
Mycobacterium tuberculosis (M. tb) is emerging as a more serious pathogen due to the increased multidrug-resistant TB and co-infection of human immunodeficiency virus (HIV). The development an effective sensitive detection method urgently needed for bacterial load evaluation in vaccine development, early diagnosis, treatment. Droplet digital polymerase chain reaction (ddPCR) newly developed PCR absolute quantification nucleic acid concentrations. Here, we used ddPCR quantify circulating...
Little is known about mortality of opiate users attending methadone maintenance treatment (MMT) clinics. We sought to investigate and its predictors among human immunodeficiency virus (HIV)-positive MMT clients.Records 306 786 clients enrolled in China's program from 24 March 2004 30 April 2011 were abstracted. Mortality rates calculated for all HIV-positive antiretroviral (ART)-naive ART-experienced clients. Risk factors examined using stratified proportional hazard ratios (HRs).The...
Gay, bisexual, and other men who have sex with (MSM), particularly Black or African American MSM (BMSM) Hispanic Latino (HLMSM), continue to be disproportionately affected by the HIV epidemic in United States. Previous self-testing programs yielded high testing rates, although these studies predominantly enrolled White, non-Hispanic MSM. Mobile health tools can support prevention, testing, treatment. This protocol details an implementation study of mailing free self-tests (HIVSTs) nested...
Pre-exposure prophylaxis (PrEP) with anti-viral drugs is currently in clinical trials for the prevention of HIV infection. Induction adaptive immune responses to virus exposures during drug administration, i.e., a "chemo-vaccination" effect, could contribute PrEP efficacy. To study possible chemo-vaccination, we monitored humoral and cellular nine rhesus macaques undergoing up 14 weekly, low-dose SHIVSF162P3 rectal exposures. Six concurrently received intermittent, oral Truvada; three were...
Since 2014, the recommended algorithm for laboratory diagnosis of HIV infection in United States has consisted an HIV-1/2 antigen/antibody (Ag/Ab) test followed by antibody (Ab) differentiation and, if necessary, a diagnostic HIV-1 nucleic acid to resolve discordant or indeterminate results.Using stored specimens from persons seeking testing who had not received previous treatment, we compared performance 3-step alternative consisting Ag/Ab quantitative RNA viral load assay is detected, Ab...
In the US, one in six men who have sex with (MSM) HIV are unaware of their infection. certain circumstances, access to testing and viral load (VL) monitoring is challenging. The objective this study was evaluate feasibility conducting laboratory-based antiretroviral (ARV) drug testing, VL as part two studies on self-collected dried blood spots (DBS).
There is benefit to early HIV-1 diagnosis and treatment, but there no Food Drug Administration-approved quantitative assay with a diagnostic claim. We compared the performance of Hologic Aptima Quant (APT-Quant) Qual (APT-Qual) assays for use algorithm consisting Bio-Rad BioPlex 2200 HIV Ag-Ab (BPC) followed by APT-Quant (2-test) BPC Geenius HIV-1/2 supplemental (Geenius) reflex APT-Qual (3-test).
Background Serological assays to determine HIV incidence have contributed estimates of incidence, monitoring spread, and evaluation prevention strategies. Two frequently used are the Sedia HIV-1 LAg-Avidity EIA (LAg) Bio-Rad avidity (BRAI) with a mean duration recent infection (MDRI) 130 240 days for subtype B infections, respectively. Little is known about how these perform recombinant strains. We evaluated concordance in population infected mainly CRF06_cpx. Material/Methods Remnant serum...
We set out to identify factors associated with unprotected sex among HIV-positive patients on methadone maintenance therapy (MMT) in China.We conducted a cross-sectional study 60 MMT clinics Yunnan, Sichuan, Guizhou, Guangxi, and Xinjiang provinces, China, total of 2742 participants.The median age participants was 35 years (range, 19-63 years), 78.3% were male. More than half (1471/2742; 53.6%) married, 6.4% (176/2742) had regular partner, 3.5% (95/2742) 1 or more occasional partners. Among...
Objective: Passive immunization with broadly neutralizing antibodies (bNAbs) is under evaluation for HIV prevention. BNAbs target gp120 or gp41, two envelope antigens commonly present in diagnostic tests. Depending on bNAb type and dose administered to humans, serum levels can reach nearly 1 mg/ml wane over several weeks months. We investigated the reactivity of bNAbs serological tests inform testing practices persons treated these products. Design methods: The antigp120 VRCO1, PGT121,...