A5066724088- Muscle metabolism and nutrition
- Adipose Tissue and Metabolism
- Cardiovascular and exercise physiology
- Parathyroid Disorders and Treatments
- Diet and metabolism studies
- Nutrition and Health in Aging
- Obesity, Physical Activity, Diet
- Genetic Syndromes and Imprinting
- Sports Performance and Training
- Vitamin D Research Studies
- Fatty Acid Research and Health
- Nutritional Studies and Diet
- Physical Activity and Health
- Sleep and related disorders
- Exercise and Physiological Responses
- Obstructive Sleep Apnea Research
- Cannabis and Cannabinoid Research
- Dietary Effects on Health
- Body Composition Measurement Techniques
- Lipid metabolism and biosynthesis
- Diet, Metabolism, and Disease
- Muscle activation and electromyography studies
- Thermoregulation and physiological responses
- Heart Rate Variability and Autonomic Control
- Eicosanoids and Hypertension Pharmacology
Universidad de Granada
2017-2025
Centro de Investigación Biomédica en Red
2025
Instituto de Salud Carlos III
2025
Institute of Space Sciences
2024
Vrije Universiteit Amsterdam
2024
Instituto de Investigación Biosanitaria de Granada
2023
Obesity is the leading cause of obstructive sleep apnea (OSA); however, effects weight loss and lifestyle interventions on OSA comorbidities remain uncertain.
Exercise holds promise as a non-pharmacological intervention for the improvement of sleep quality. Therefore, this study investigates effects different training modalities on quality parameters.A total 69 (52.7% women) middle-aged sedentary adults were randomized to (a) control group, (b) physical activity recommendation from World Health Organization, (c) high-intensity interval (HIIT) and (d) group adding whole-body electromyostimulation (HIITEMS). Sleep was assessed using Pittsburgh...
Abstract Exercise modulates both brown adipose tissue (BAT) metabolism and white (WAT) browning in murine models. Whether this is true humans, however, has remained unknown. An unblinded randomized controlled trial (ClinicalTrials.gov ID: NCT02365129) was therefore conducted to study the effects of a 24-week supervised exercise intervention, combining endurance resistance training, on BAT volume activity (primary outcome). The carried out Sport Health University Research Institute Virgen de...
The secreted form of the α-Klotho gene (S-Klotho), which is considered a powerful biomarker longevity, makes it an attractive target as anti-ageing therapy against functional decline, sarcopenic obesity, metabolic and cardiovascular diseases, osteoporosis, neurodegenerative disorders. S-Klotho plasma levels could be related to physical exercise inasmuch involved in physiological pathways that regulate levels. FIT-AGEING will determine effect different training modalities on (primary outcome)...
This study aimed to investigate the influence of different exercise training modalities [(i) a concurrent based on physical activity recommendation from World Health Organization group (PAR group), (ii) high intensity interval (HIIT and (iii) adding whole-body electromyostimulation (WB-EMS group)] fitness in sedentary middle-aged adults. A total 89 (52.7% women) adults (53.7 ± 5.1 years old) were enrolled FIT-AGING study. Cardiorespiratory was determined by maximum treadmill test using...
Succinate is produced by both host and microbiota, with a key role in the interplay of immunity metabolism an emerging as biomarker for inflammatory metabolic disorders middle-aged adults. The relationship between plasma succinate levels cardiovascular disease (CVD) risk young adults unknown.Cross-sectional study 100 (65% women) individuals aged 18-25 years from ACTIvating Brown Adipose Tissue through Exercise (ACTIBATE) cohort. CVD factors, body composition, dietary intake, basal rate,...
BackgroundThere is a subset of individuals with overweight/obesity characterized by lower risk cardiometabolic complications, the so-called metabolically healthy (MHOO) phenotype. Despite relatively higher levels subcutaneous adipose tissue and visceral observed in MHOO than unhealthy (MUOO), little known about differences brown (BAT).MethodsThis study included 53 young adults (28 women) body mass index (BMI) ≥25 kg/m2 which were classified as (n = 34) or MUOO 19). BAT was assessed through...
Cold exposure activates brown adipose tissue (BAT) and potentially improves cardiometabolic health through the secretion of signaling lipids by BAT. Here, we show that 2 h cold in young adults increases levels omega-6 omega-3 oxylipins, endocannabinoids (eCBs) anandamide docosahexaenoylethanolamine, lysophospholipids containing polyunsaturated fatty acids. Contrarily, it decreases eCBs 1-LG 2-LG 1-OG 2-OG, lysophosphatidic acids, lysophosphatidylethanolamines. Participants overweight or...
α-Klotho protein is a powerful predictor of the aging process and lifespan. Although lowered circulating soluble levels have been observed in aged non-healthy individuals, no specific reference values across wide range ages sex using an enzyme-linked immunosorbent assay (ELISA) are available for larger cohorts healthy individuals. The present analytical cross-sectional study was aimed to establish serum adults by age groups. A total 346 (59% women) individuals from 18 85 years were...
Background/Objectives: Sports performance is influenced by a complex interplay of physical, physiological, and psychological factors, which differ across disciplines. Thus, this study aims to identify compare the distinct multidimensional profiles (i.e., body composition, diet, resting metabolic rate, physical activity, sleep quality, subjective well-being) athletes from different sports disciplines endurance, strength, intermittent sports). Methods: This included 77 (28 women) classified as...
Indirect calorimetry (IC) is considered the reference method to determine resting energy expenditure (REE), but its use in a clinical context limited. Alternatively, there number of REE predictive equations estimate REE. However, it has been shown that available could either overestimate or underestimate as measured by IC. Moreover, role weight status accuracy and validity requires further attention. Therefore, this study aimed normal-weight, overweight, obese sedentary middle-aged adults. A...
This study aimed to investigate the effects of different training modalities on soluble Klotho (S-Klotho) plasma levels in sedentary middle-aged adults. A total 74 adults (53.4 ± 5.0 years old; 52.7% women) were enrolled FIT-AGEING study. We conducted a 12-week randomised controlled trial. The participants randomly assigned 4 groups: (i) control group (no exercise), (ii) physical activity recommendation from World Health Organization (PAR), (iii) high intensity interval (HIIT), and (iv)...
Abstract Objective Omega‐6 and omega‐3 oxylipins are known to play a role in inflammation cardiometabolic diseases preclinical models. The associations between plasma levels of omega‐6 polyunsaturated fatty acid–derived body composition risk factors young adults were assessed. Methods Body composition, brown adipose tissue, traditional serum factors, inflammatory markers, panel 83 analyzed 133 (age 22.1[SD 2.2] years, 67% women). Results Plasma four (15‐HeTrE, 5‐HETE, 14,15‐EpETrE, the...
Introduction Several metabolite classes have been identified in human endometrium, including lipids, nucleotides, amino acids, organic and sugars. The first studies suggest the importance of metabolites endometrial functions, as imbalance uterine has associated with low implantation rate endometriosis. Nevertheless, most put emphasis on specific classes, we lack knowledge whole metabolome composition uterus. Further, a healthy dietary pattern shown to potentially protect against different...
To analyze the diurnal variation of maximal fat oxidation (MFO) and intensity that elicits MFO (Fatmax) in trained male athletes.A total 12 endurance-trained athletes age 24.7 (4.1) y participated study. The authors measured MFO, Fatmax, maximum oxygen uptake (VO2max), VO2 percentage at ventilatory threshold 2 with a graded exercise protocol performed on days separated by 1 wk. One test was morning other afternoon. assessed participants' chronotype using HÖME questionnaire.MFO Fatmax were...
We aimed to investigate the effects of different exercise training programs on body composition parameters in sedentary middle‐aged adults. A total 89 adults (53.5 ± 4.9 years old; ~53% women) participated FIT‐AGEING study. 12‐week randomized controlled trial was performed with a parallel group design. The participants were randomly assigned (a) concurrent based physical activity recommendation from World Health Organization (PAR group), (b) high‐intensity interval (HIIT and (c) adding...
This cross-sectional study investigates the relationship between shed form of Klotho protein (S-Klotho) in plasma, and cardiometabolic risk healthy, sedentary adults.The subjects were 214 adults (~64% women).Data collected during baseline assessments two randomized controlled trials: The FIT-AGEING (n=74 [~50% women] middle-aged aged 40-65 years) ACTIBATE (n=140 [~70% young 18-25 years).A sex-specific score was calculated for each subject based on waist circumference, systolic diastolic...
Regular physical activity (PA) is an important part of the treatment several medical conditions, including overweight and obesity, in which there may be a weakened appetite control. Eating behaviour traits influence weight control different active sedentary subjects. This paper reports relationships between time spent intensity, eating young, healthy adults. Additionally, it results six-month-long, randomized, controlled trial to examine effect exercise intervention on traits. A total 139...