A5058255615- Microtubule and mitosis dynamics
- Cellular transport and secretion
- Pluripotent Stem Cells Research
- Genetic and Kidney Cyst Diseases
- Genetics, Aging, and Longevity in Model Organisms
- Autophagy in Disease and Therapy
- RNA Interference and Gene Delivery
- Epigenetics and DNA Methylation
- Cellular Mechanics and Interactions
- Muscle Physiology and Disorders
- Plant Molecular Biology Research
- Ubiquitin and proteasome pathways
- CRISPR and Genetic Engineering
- Neurogenesis and neuroplasticity mechanisms
- Microbial Community Ecology and Physiology
- Nuclear Structure and Function
- Cardiomyopathy and Myosin Studies
- Mitochondrial Function and Pathology
- Photosynthetic Processes and Mechanisms
- Neurobiology and Insect Physiology Research
- Retinal Development and Disorders
- Genetics, Bioinformatics, and Biomedical Research
- Fungal and yeast genetics research
- Adipose Tissue and Metabolism
- Science, Research, and Medicine
École Polytechnique Fédérale de Lausanne
2010
University of Geneva
2006
University of Cambridge
2003
Wellcome Trust
2003
Wellcome/Cancer Research UK Gurdon Institute
2003
European Bioinformatics Institute
2001
European Molecular Biology Laboratory
2001
Institut Curie
1998
Indiana University – Purdue University Indianapolis
1998
University of Illinois Urbana-Champaign
1998
Melanophores move pigment organelles (melanosomes) from the cell center to periphery and vice-versa. These bidirectional movements require cytoplasmic microtubules microfilaments depend on function of microtubule motors a myosin. Earlier we found that melanosomes purified Xenopus melanophores contain plus end motor kinesin II, indicating it may be involved in dispersion (Rogers, S.L., I.S. Tint, P.C. Fanapour, V.I. Gelfand. 1997. Proc. Natl. Acad. Sci. USA. 94: 3720–3725). Here, generated...
The effect of phosphorus (P) and nitrogen (N) additions on the Synechococcus cell cycle was tested with natural populations from Mediterranean Sea in summer. In absence stimulation, synchronized to light-dark cycle. DNA synthesis began around 1600, a maximum S-phase cells observed at dusk (2100), G(inf2)-phase 2400. Addition P (as PO(inf4)(sup3-)) caused, all cases, decrease fraction G(inf2) 1800, no change 2400, an increase 1200 next day, while addition N NO(inf3)(sup-)) had effect. We...
Because of their tiny size (0.2 to 2 microns), oceanic picophytoplanktonic cells (either cultured strains or natural communities) are difficult identify, and some basic questions concerning taxonomy, physiology, ecology still largely unanswered. The present study was designed test the suitability in situ hybridization with rRNA fluorescent probes detected by flow cytometry for identification small photosynthetic eukaryotes. Oligonucleotide targeted against regions 18S rRNAs Chlorophyta...
Neurexins (NRXNs) are synaptic cell adhesion molecules having essential roles in the assembly and maturation of synapses into fully functional units. Immunocytochemical electrophysiological studies have shown that specific binding across cleft ectodomains presynaptic NRXNs postsynaptic neuroligins potential to bidirectionally coordinate trigger synapse formation. Moreover, vivo as well genome-wide association pointed out implication pathogenesis cognitive disorders including autism spectrum...
The function of the Golgi apparatus is to modify proteins and lipids synthesized in ER sort them their final destination. steady-state size maintained through recycling some components back ER. Several lines evidence indicate that spatial segregation between as well trafficking these two compartments require both microtubules motors. We have cloned characterized a new Xenopus kinesin like protein, Xklp3, subunit heterotrimeric Kinesin II. By immunofluorescence it found region. A more...
Cell polarity is essential for many decisions made during development. While investigation of polarity-specific factors has yielded great insights into the polarization process, little known on how these link to basic cellular mechanisms that function in non-polarity aspects cell. To better understand establish embryonic polarity, we investigated genes required one-cell C. elegans embryo are also other functions. This led identification Pod-class mutants characterized by osmosensitive...
Nuclear receptors (NRs) are a large family of transcription factors. One hallmark this is the ligand-binding domain (LBD), for its primary sequence, structure, and regulatory function. To date, NRs have been found exclusively in animals sponges, which has led to generally accepted notion that they arose with them. We overcome limitations sequence searches by combining profile structural predictions at genomic scale, discovered heterodimeric factors Oaf1/Pip2 budding yeast Saccharomyces...