A5017115123- Cellular Mechanics and Interactions
- 3D Printing in Biomedical Research
- Bioinformatics and Genomic Networks
- Microbial Metabolic Engineering and Bioproduction
- Bone Tissue Engineering Materials
- Machine Learning in Bioinformatics
- Quantum Dots Synthesis And Properties
- Polymer Surface Interaction Studies
- Gold and Silver Nanoparticles Synthesis and Applications
- Protein Structure and Dynamics
- Ferroelectric and Piezoelectric Materials
- Multiferroics and related materials
- Computational Drug Discovery Methods
- Seaweed-derived Bioactive Compounds
- Microwave Dielectric Ceramics Synthesis
- Retinal Development and Disorders
- biodegradable polymer synthesis and properties
- Meat and Animal Product Quality
- Advanced Polymer Synthesis and Characterization
- Plasmonic and Surface Plasmon Research
- Fatty Acid Research and Health
- Retinoids in leukemia and cellular processes
- RNA Research and Splicing
- RNA regulation and disease
- Nanofabrication and Lithography Techniques
Fudan University
2020-2023
Affiliated Eye Hospital of Wenzhou Medical College
2021-2023
Wenzhou Medical University
2021-2023
Guangzhou University
2023
Institute of Animal Sciences
2022
Chinese Academy of Agricultural Sciences
2022
Northwestern Polytechnical University
2018-2020
Zhejiang University
2012-2017
State Key Laboratory of Silicon Materials
2012
Materials Science & Engineering
2012
Surface topography is a biophysical factor affecting cell behaviors, yet the underlying cues are still not clear. Herein, we hypothesized that stereo coverage and overall stiffness of biomaterial arrays on scale single cells underly parts effects adhesion. We fabricated series microarrays (micropillar, micropit, microtube) poly(l-lactic acid) (PLLA) using mold casting based pre-designed templates. The characteristic sizes array units were less than cell, thus, each could sense micropatterns...
Enabling a biodegradable polymer radiopaque under X-ray is much desired for many medical devices. Physical blending of present and commercialized contrast agent convenient yet lacks comprehensive fundamental research. Herein, we prepared polymer-based raw material by poly(l-lactic acid) (PLLA or simply PLA) iohexol (IHX), where PLA constituted the continuous phase IHX particles served as dispersed phase. The strong adsorption enabled composite radiopaque; hydrolysis polyester water...
Directed migration of cells through cell-surface interactions is a paramount prerequisite in biomaterial-induced tissue regeneration. However, whether and how the nanoscale spatial gradient adhesion molecules on material surface can induce directed not sufficiently known. Herein, we employed block copolymer micelle nanolithography to prepare gold nanoarrays with nanospacing gradient, which were prepared by continuously changing dipping velocity. Then, self-assembly monolayer technique was...
Although many tissue regeneration processes after biomaterial implantation are related to migrations of multiple cell types on material surfaces, available tools adjust relative migration speeds very limited. Herein, we put forward a nanomaterial strategy employ surface modification with arginine-glycine-aspartate (RGD) nanoarrays tune in vitro using endothelial cells (ECs) and smooth muscle (SMCs) as demonstrated types. We found that both exhibited nonmonotonic trend the increase RGD...
Docosahexaenoic acid (DHA) can improve human and animal health, particularly including anti-inflammatory, antioxidant, anticancer, neurological, visual functions. Schizochytrium sp. is a marine heterotrophic protist producing oil with high DHA content, which widely used in food production. However, different fermentation conditions have intensive impacts on the growth content of Thus, this study aimed to enhance yield concentration I-F-9 by optimizing medium. First, single-factor design was...
The decreased antioxidant capacity in the retinal pigment epithelium (RPE) is hallmark of degenerative diseases including age-related macular degeneration (AMD). Nevertheless, exact regulatory mechanisms underlying pathogenesis degenerations remain largely unknown. Here we show mice that deficiencies Dapl1, a susceptibility gene for human AMD, impair RPE and lead to 18-month-old homozygous partial deletion Dapl1. Dapl1-deficiency associated with reduction RPE's capacity, experimental...
Transcription factors (TFs) play important roles in the regulation of gene expression. They can activate or block transcription downstream genes a manner binding to specific genomic sequences. Therefore, motif discovery these preference patterns is central significance understanding molecular mechanism. Many algorithms have been proposed for identification factor sites. However, it remains challengeable problem. Here, we novel algorithm based on support vector machine (MD-SVM) learn...
The discovery of functionally conserved proteins is a tough and important task in system biology. Global network alignment provides systematic framework to search for these from multiple protein-protein interaction (PPI) networks. Although there exist many web servers alignment, no one allows perform global tasks on users’ test datasets. Here, we developed server WebNetcoffee based the algorithm NetCoffee To build series online datasets, manually collected 218,339 proteins, 4,009,541...
Purpose: Retinal pigment epithelium (RPE) cell proliferation is precisely regulated to maintain retinal homoeostasis. Microphthalmia-associated transcription factor (MITF), a critical in RPE cells, has two alternatively spliced isoforms: (+)MITF and (−)MITF. Previous work shown that (−)MITF but not inhibits proliferation. This study aims investigate the role of long non-coding RNA (lncRNA) nuclear-enriched abundant transcript 1 (NEAT1) regulating MITF splicing hence cells. Methods: Mouse...
Heat stress (HS) alters the rumen fermentation of dairy cows thereby affecting metabolism papillae and thus epithelial barrier function. The aim present study was to investigate if HS damages function ruminal epithelia. Eight multiparous Holstein with cannula were randomly equally allocated two replicates ( n = 4), each replicate being subjected heat or thermal neutrality pair-feeding in four environmental chambers. Micromorphological observation showed aggravated shedding corneum destroyed...
Shape-controlled synthesis of tetragonal PbZr0.52Ti0.48O3 (PZT) perovskite nanocrystallites, microrolls, microrods and 3D complex architectures composed microroll-bundles or microrod-bundles were realized via a hydrothermal reaction route by simply adjusting the poly-vinylalcohol (PVA) KOH concentrations. X-ray diffraction (XRD), scanning electron microscopy (SEM), high-resolution transmission (HRTEM), differential temperature thermogravimetric analysis (DTA TG) used to characterize phase...
Abstract Background Network alignment is an efficient computational framework in the prediction of protein function and phylogenetic relationships systems biology. However, most existing methods focus on aligning PPIs based static network model, which are actually dynamic real-world systems. The characteristic PPI networks essential for understanding evolution regulation mechanism at molecular level there still much room to improve quality networks. Results In this paper, we proposed a novel...
Proteins play essential roles in almost all life processes. The prediction of protein function is significance for the understanding molecular and evolution. Network alignment provides a fast effective framework to automatically identify functionally conserved proteins systematic way. However, due growing genomic data, interactions annotation there an increasing demand more accurate efficient tools deal with multiple PPI networks. Here, we present novel global algorithm NetCoffee2 based on...
Lead titanate nanostructures with different phases and morphologies, layered hexagonal PbTiO 2 (CO 3 ) 0.3 ‐ (NO 0.35 (OH) nanosheets, pyrochlore Pb Ti O 6 nanodendites, pre‐perovskite nanofibres perovskite nanoplates, have been synthesized via a conventional hydrothermal route assisted concentrations of tetramethylammonium hydroxide (TMAH). X‐ray diffraction (XRD), scanning electron microscopy (SEM), transmission (TEM), high‐resolution TEM (HRTEM) were employed to characterize the phase,...