Kun Zhang

ORCID: 0000-0002-5280-4479
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About
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Research Areas
  • Ear Surgery and Otitis Media
  • Pelvic and Acetabular Injuries
  • Osteoarthritis Treatment and Mechanisms
  • Pelvic floor disorders treatments
  • Sarcoma Diagnosis and Treatment
  • Ear and Head Tumors
  • Bone Tumor Diagnosis and Treatments
  • Folate and B Vitamins Research
  • IgG4-Related and Inflammatory Diseases
  • Urinary Bladder and Prostate Research
  • Vestibular and auditory disorders
  • Bone and Joint Diseases
  • Mesenchymal stem cell research
  • Head and Neck Cancer Studies
  • Tracheal and airway disorders
  • Hearing, Cochlea, Tinnitus, Genetics
  • Oral and Maxillofacial Pathology
  • Anorectal Disease Treatments and Outcomes
  • Oral Health Pathology and Treatment
  • Soft tissue tumors and treatment
  • Diagnosis and Treatment of Venous Diseases
  • Neurological Complications and Syndromes
  • Inflammatory Biomarkers in Disease Prognosis
  • COVID-19 and healthcare impacts
  • Venous Thromboembolism Diagnosis and Management

First Affiliated Hospital of Chengdu Medical College
2025

Wenzhou Medical University
2024

Peking University
2012-2023

Peking University Third Hospital
2016-2023

Shenzhen University Health Science Center
2023

University of Electronic Science and Technology of China
2022-2023

Sichuan Academy of Medical Sciences & Sichuan Provincial People's Hospital
2023

Zhengzhou University
2022

Fifth Affiliated Hospital of Zhengzhou University
2022

Qilu Hospital of Shandong University
2016-2022

Objective. To describe coronavirus disease 2019 (COVID-19) patient presentations requiring otolaryngology consultation and provide recommendations for protective measures based on the experience of ear, nose, throat (ENT) departments in 4 Chinese hospitals during COVID-19 pandemic. Study Design. Retrospective case series. Setting. Multicenter. Subjects Methods. Twenty hospitalized patients ENT from 3 designated Wuhan, Shanghai, Shenzhen were identified. Data demographics, comorbidities,...

10.1177/0194599820926144 article EN cc-by Otolaryngology 2020-05-12

Objective The primary aim of this scholarly investigation was to elucidate the correlation between Number Pain Sites and cognitive decline within older adult population. Additionally, study sought examine potential mediating influence depressive symptoms in moderating association pain deterioration. Methods We analyzed 8,835 participants aged 45 above, with data collected from 2011 2018. Participants were categorized into two groups—stable rapidly declining function—using KML3D clustering...

10.3389/fpubh.2025.1526086 article EN cc-by Frontiers in Public Health 2025-03-31

Elevated homocysteine (HCY) and smoking are both important risk factors for hypertensive patients. However, whether they have crossing effect on renal function deterioration of patients what is the underlying mechanism unclear. In present study, 3033 participants diagnosed as essential hypertension with estimated glomerular filtration rate (eGFR)> 30 ml/min/1.73 m2 from southern China were enrolled in this cross-sectional study. We collected demographic clinical data. addition, mediation...

10.18632/oncotarget.13308 article EN Oncotarget 2016-11-11

Radiotherapy is the primary treatment option for nasopharyngeal carcinoma (NPC). Local recurrence and metastasis caused by radioresistance become a bottleneck of curative effect patients with NPC. Currently, serum predictive biomarkers are scare. We enrolled NPC patients, who underwent radiotherapy in Department Oncology, Xiangya Hospital, Central Southern University, analyzed proteins profiles using quantitative label-free proteomics ultra-definition MS. Patients were divided into those...

10.1042/bsr20190027 article EN cc-by Bioscience Reports 2019-04-30

The aim of this study was to an antimicrobial peptide (AMP), aurein 1.2, which substantially increased protein delivery directly into multiple mammalian inner-ear cell types in vivo. Different concentrations 1.2 with superpositively charged GFP (+36 GFP) fused Cre recombinase were delivered postnatal day 1-2 (P1-2) and adult cochleae reporter transgenic mice various methods. By cochleostomy at different 1.2–+36 (1 μM, 5 22.5 50 respectively), the tdTomato (tdT) expression observed outer hair...

10.1016/j.omtm.2020.06.023 article EN cc-by-nc-nd Molecular Therapy — Methods & Clinical Development 2020-06-30

This article summarizes the experience of diagnosis and treatment temporal bone fibrous dysplasia (FD) with external auditory canal (EAC) stenosis secondary cholesteatoma in Chinese population, order to improve quality life patients future.Eleven FD who underwent surgery were retrospectively reviewed.All lesions originated from bone, all involved EAC. There 11 cases EAC, 4 middle ear. The most common symptoms hearing loss (100%), tinnitus (36.4%), otorrhea (36.4%). Two severe-profound...

10.1177/0145561320927922 article EN cc-by-nc Ear Nose & Throat Journal 2020-05-22

Background High resolution melting (HRM) is a simple, flexible and low-cost mutation screening technique. The methylenetetrahydrofolate reductase (MTHFR) gene encoding critical enzyme, potentially affects susceptibility to some congenital defects like heart disease (CHD). We evaluate the performance of HRM for genotyping MTHFR C677T locus in CHD cases healthy controls Chinese Han population. Methods A total 315 blood samples from 147 patients (male72, female 75) 168 (male 92, 76) were...

10.1371/journal.pone.0151140 article EN cc-by PLoS ONE 2016-03-18

Background: Temporal bone chondrosarcoma (TBC) are uncommon primary temporal malignancies, and clinicians lack experience in its diagnosis treatment. The optimal management of patients with tumor TBC also remains a topic debate controversy. Objectives: This article summarizes the treatment TBC, order to improve quality life cancer future. Material methods: We conducted retrospective analysis 10 who were referred our hospital from June 2009 2018 for TBC. Results: There 3 males 7 females. most...

10.1080/00016489.2019.1641220 article EN Acta Oto-Laryngologica 2019-08-02

This study is aimed at investigating the tissue reactions of heterogenic and allogeneic acellular dermal matrix (ADM) mesh implanted in vesicovaginal space a rabbit model.Twenty eight rabbits were with or mesh, respectively, space, 4 served as no-implantation control group. Rabbits sacrificed 7, 30, 90 days after implantation. Histopathological immunohistochemical examination for collagen performed.Heterogenic but not was identifiable days. In group, neovascularization observed from day 7 A...

10.1159/000449414 article EN Gynecologic and Obstetric Investigation 2016-09-14

To investigate the characteristics of cerebral perfusion and hemodynamics bypass grafting in treatment moyamoya disease (MMD) using iFlow color-coded flow map comparison with magnetic resonance imaging-perfusion-weighted imaging (MRI-PWI) computational fluid dynamic (CFD) analysis.Patients MMD treated who had undergone MRI PWI digital subtraction angiography for was retrospectively enrolled CFD performed calculating hemodynamic stresses around grafting.Forty-five patients unilateral surgery...

10.3389/fnins.2022.922482 article EN cc-by Frontiers in Neuroscience 2022-06-14

BACKGROUND Myopericytoma is a benign tumor that typically occurs within subcutaneous tissue and most often involves the distal extremities, followed by proximal neck, thoracic vertebrae oral cavity. Complete resection curative. Malignant myopericytoma extremely rare has poor prognosis. Here, we report for first time case of malignant originating from colon. CASE SUMMARY A 69-year-old male was admitted to our hospital with right upper quadrant pain five days. Imaging suggested liver mass...

10.4240/wjgs.v16.i6.1918 article EN World Journal of Gastrointestinal Surgery 2024-06-27

Background: Frequency-specific hearing studies are important for predicting results and the prognosis after stapes surgery, to prepare rehabilitation of frequency-specific in patients with otosclerosis.Objectives: To evaluate outcomes surgery Chinese otosclerosis different degrees loss.Methods: We conducted a retrospective analysis 213 who underwent our hospital. Pre- post-operative audiometric evaluation using conventional audiometry.Results: The post-op ABG was less than 20 dB 94.52% all...

10.1080/00016489.2020.1724331 article EN Acta Oto-Laryngologica 2020-02-18

Otogenic brain abscess caused by middle ear cholesteatoma is a potentially serious and life-threatening complication in the ear, nose, throat clinic. The mortality rate associated with otogenic abscesses 8%-26.3%. Recently, China, incidence of secondary to has started increase due antibiotic resistance.A 55-year-old male presented hearing loss right headache for 1 mo 2018. Computed tomography (CT) showed an area low density mastoid auditory ossicle defects small amount soft tissue left ear....

10.12998/wjcc.v10.i28.10220 article EN World Journal of Clinical Cases 2022-09-26

The aim of this study was to determine the prevalence facial nerve (FN) bifurcation in patients who undergo stapes surgery, and ascertain correlation between intraoperative radiographic findings cases where an unexpected branch malformation for undergoing surgery. Patients underwent surgery were retroactively examined confirmed FN bifurcation. Among 887 patients, 10 had a bifurcated during preoperative high-resolution computed tomography (HRCT) scan. HRCT scans by two radiologists blinded...

10.1159/000523926 article EN ORL 2022-01-01
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