A5021932774- Nanoparticle-Based Drug Delivery
- Molecular Communication and Nanonetworks
- Amyotrophic Lateral Sclerosis Research
- Barrier Structure and Function Studies
- Extracellular vesicles in disease
- Micro and Nano Robotics
- Advanced Polymer Synthesis and Characterization
- Lipid Membrane Structure and Behavior
- Cellular transport and secretion
- Neurogenetic and Muscular Disorders Research
- Microfluidic and Bio-sensing Technologies
- Connexins and lens biology
- Labor Movements and Unions
- Polymer Surface Interaction Studies
- Free Radicals and Antioxidants
- International Environmental Law and Policies
- Pickering emulsions and particle stabilization
- Regulation and Compliance Studies
- Heat shock proteins research
- Characterization and Applications of Magnetic Nanoparticles
- Photoreceptor and optogenetics research
- Nanoplatforms for cancer theranostics
- Social and Educational Sciences
- biodegradable polymer synthesis and properties
- Caveolin-1 and cellular processes
University of Sheffield
2013-2022
University College London
2015-2020
Sunnybrook Research Institute
2016-2019
Sunnybrook Health Science Centre
2017-2019
Sunnybrook Hospital
2016
Brain homing nanoswimmers: Glucose-fueled propulsion combined with blood-brain barrier crossing enhances brain delivery.
The blood-brain barrier (BBB) is by far the most important target in developing new approaches to improve delivery of drugs and diagnostic tools into Central Nervous System (CNS). Here we report engineering pH- sensitive polymersomes (synthetic vesicles formed amphiphilic copolymers) that exploit endogenous transport mechanisms traverse BBB, enabling large macromolecules both CNS parenchyma cells. We achieve this targeting Low Density Lipoprotein Receptor-Related Protein 1 (LRP-1) receptor....
The blood-brain barrier is made of polarized brain endothelial cells (BECs) phenotypically conditioned by the central nervous system (CNS). Although transport across BECs paramount importance for nutrient uptake as well ridding waste products, intracellular sorting mechanisms that regulate successful receptor-mediated transcytosis in remain to be elucidated. Here, we used a synthetic multivalent with tunable avidity low-density lipoprotein receptor-related protein 1 (LRP1) investigate BECs....
Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease with no effective cure. Astrocytes display toxic phenotype in ALS and contribute to motoneuron (MN) degeneration. Modulating astrocytes' neurotoxicity can reduce MN death. Our previous studies showed the beneficial effect of mesenchymal stem cell (MSC) administration SOD1G93A mice, but mechanisms are still unclear. We postulated that effects could be mediated by extracellular vesicles (EVs) secreted MSCs. investigated,...
Amyotrophic lateral sclerosis (ALS) is characterised by motor neuron (MN) death; however, astrocytes play a key role in disease pathogenesis. Developments the field of artificial intelligence (AI) have potential to impact drug discovery multiple ways, including rapid identification repurposing candidates. A combination natural language processing and deep learning algorithms was used generate knowledge graph based on scientific literature, omics chemical databases, other public sources with...
Stroke is one of the commonest causes death with limited treatment options. L-Carnosine has shown great promise as a neuroprotective agent in experimental stroke, but translation to clinic impeded by large doses needed. We developed and evaluated therapeutic potential novel delivery vehicle which encapsulated carnosine lipoprotein receptor related protein-1 (LRP-1)-targeted functionalized polymersomes ischemic stroke. found that following encapsulating exhibited remarkable effects dose 3...
In recent years, scientists have created artificial microscopic and nanoscopic self-propelling particles, often referred to as nano- or micro-swimmers, capable of mimicking biological locomotion taxis. This active diffusion enables the engineering complex operations that so far not been possible at micro- nanoscale. One most promising task is ability engineer nanocarriers can autonomously navigate within tissues organs, accessing nearly every site human body guided by endogenous chemical...
<h3>Background</h3> Exosomes -– nano-sized, lipidvesicles released by cells into the blood – can protect myocardium against ischaemia/reperfusion (IR) injury.<sup>1</sup> This cardioprotection is mediated heat shock protein 70 (HSP70) on exosome surface interacting with Toll-like receptor 4 (TLR-4) cardiomyocytes and activating intracellular protective signalling kinases.<sup>1</sup> Polymersomes are synthetic nanovesicles a structural similarity to exosomes, capacity function as drug...
The blood-brain barrier is made of polarised brain endothelial cells (BECs) phenotypically conditioned by the central nervous system (CNS). Transport across BECs paramount importance for nutrient uptake as well to rid waste products. Nevertheless, currently we do not understand how large macromolecular cargo shuttles and discriminate between brain-bound own nutrients. Here, study low-density lipoprotein receptor-related protein 1 (LRP1) an essential regulator BEC transport, show that it...