A5040994709- Multiple Sclerosis Research Studies
- T-cell and B-cell Immunology
- Immunotherapy and Immune Responses
- Neuroinflammation and Neurodegeneration Mechanisms
- Mesenchymal stem cell research
- Amyotrophic Lateral Sclerosis Research
- Extracellular vesicles in disease
- Peripheral Neuropathies and Disorders
- Neurogenesis and neuroplasticity mechanisms
- Chemokine receptors and signaling
- Immune Cell Function and Interaction
- Immune Response and Inflammation
- Immune cells in cancer
- Systemic Lupus Erythematosus Research
- Bone and Joint Diseases
- MicroRNA in disease regulation
- Cell Adhesion Molecules Research
- Neurogenetic and Muscular Disorders Research
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- RNA Interference and Gene Delivery
- Endoplasmic Reticulum Stress and Disease
- Glioma Diagnosis and Treatment
- Immunodeficiency and Autoimmune Disorders
- Sarcoidosis and Beryllium Toxicity Research
- Macrophage Migration Inhibitory Factor
University of Genoa
2006-2024
Ospedale Policlinico San Martino
2005-2024
Istituto Giannina Gaslini
2005
Istituti di Ricovero e Cura a Carattere Scientifico
2005
University of California, San Francisco
1997
Clonally expanded populations of B cells carrying somatic mutations Ig variable (V) region genes have been detected in the CNS subjects with multiple sclerosis (MS), suggesting that a process cell affinity maturation ensuing production potentially pathogenic autoantibodies may occur inside CNS. Here, we characterized subsets present cerebrospinal fluid (CSF) MS patients and individuals other inflammatory neurological disorders by flow cytometry. CD19 + CD38 high+ CD77 , Ki67 Bcl-2 –...
Despite some advances in the understanding of amyotrophic lateral sclerosis (ALS) pathogenesis, significant achievements treating this disease are still lacking. Mesenchymal stromal (stem) cells (MSCs) have been shown to be effective several models neurological disease. To determine effects intravenous injection MSCs an ALS mouse model during symptomatic stage disease, (1 × 106) were intravenously injected mice expressing human superoxide dismutase 1 (SOD1) carrying G93A mutation (SOD1/G93A)...
Abstract Mesenchymal stem cells (MSC) display a remarkable ability to modulate the immune response and protect central nervous system mainly through release of soluble factors in paracrine fashion, affecting functional behavior tissues. Here we investigated effect interaction between MSC microglia vitro, dissected molecular cellular mechanisms this crosstalk. We demonstrated that impair activation by inflammatory cues inhibition expression molecules stress-associated proteins. showed...
Abstract Mesenchymal stromal/stem cells (MSCs) are characterized by neuroprotective, immunomodulatory, and neuroregenerative properties, which support their therapeutic potential for inflammatory/neurodegenerative diseases, including multiple sclerosis (MS) amyotrophic lateral (ALS). One mode of action through MSCs exert immunomodulatory effects is release extracellular vesicles that carry proteins, mRNAs, microRNAs (miRNAs), which, once transferred, modify the function target cells. We...
Abstract The recruitment of lymphocytes across the blood brain barrier (BBB) is mediated by adhesion molecules and chemokines. expression activation markers chemokine receptors on T cells homing to nervous system (NS) may help define their functional state. In cerebrospinal fluid (CSF) subjects with inflammatory neurological diseases (IND), including multiple sclerosis, we observed an increased number coexpressing CXCR3 CCR5 as well a CD45RO+ CCR7+ CD27+ memory phenotype. A subset...
T-lymphocytes with T-cell antigen receptor (TCR) comprising a γ chain and δ (γδ+ T cells) are believed to be involved in the immune reaction mycobacterial antigens, they have been found increased proportions sarcoid patients. We evaluated of γδ+ two major subpopulations, Vδ1+ Vδ2+ subsets, 10 normal blood donors, 15 patients tuberculosis (TB), seven whom had pleural effusion (PE), 12 pulmonary sarcoidosis (PS), nine underwent bronchoalveolar lavage (BAL). subsets were peripheral (PBL) all...
Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease with no effective cure. Astrocytes display toxic phenotype in ALS and contribute to motoneuron (MN) degeneration. Modulating astrocytes' neurotoxicity can reduce MN death. Our previous studies showed the beneficial effect of mesenchymal stem cell (MSC) administration SOD1G93A mice, but mechanisms are still unclear. We postulated that effects could be mediated by extracellular vesicles (EVs) secreted MSCs. investigated,...
Abstract Callithrix jacchus is an outbred New World primate characterized by a naturally occurring bone marrow chimerism, restricted polymorphism at many MHC loci, and unusual susceptibility to viral pathogens, adenocarcinoma, colitis, and, following immunization with myelin antigens, demyelinating disease of the central nervous system closely resembling human multiple sclerosis. Here we characterize TCRB repertoire in this species, representing first such analysis monkey. Two TCRBC, 13 BJ,...
Although many studies have shown that administration of stem cells after focal cerebral ischemia improves brain damage, very little data are available concerning the damage induced by global ischemia. The latter causes neuronal death in selectively vulnerable areas, including hippocampal CA1 region. We tested hypothesis intravenous infusion bone marrowderived stromal (mesenchimal cells, MSC) reduce transient In adult male Sprague-Dawley rats was using bilateral common carotid artery...
Although graft vs. host disease (GvHD) is a frequent complication of allogeneic bone marrow transplantation (BMT), involvement the central and peripheral nervous systems (CNS PNS, respectively) has not been demonstrated conclusively. Here, we report patient who, following BMT for lymphoblastic T‐cell lymphoma, suffered syndrome characterized by self‐remitting cerebellar pyramidal signs associated with progressive system (PNS). Clinical course laboratory findings correlated relapses systemic...
Abstract The close resemblance of MS to the animal model experimental autoimmune encephalomyelitis (EAE) has provided compelling data sustaining a pathogenic role circulating T cells reactive against MBP. cell antigen receptor (TCR) usage in EAE is commonly considered restricted; nevertheless, dynamic changes TCR correlate with course EAE, resulting limited repertoire during early stages disease activity followed by recruitment other new determinants. Although broader mediates response MBP...
The common marmoset Callithrix jacchus (C. jacchus) is an outbred species characterized by a naturally occurring bone marrow chimerism and susceptibility to form of experimental autoimmune encephalomyelitis (EAE) resembling multiple sclerosis (MS). T cell clones specific for the myelin antigen, basic protein (MBP), can be derived from both naive immunized marmosets adoptively transfer EAE compatible chimeric siblings. Here, we demonstrate that severel different antigenic determinants MBP are...