A5008424784- Amyotrophic Lateral Sclerosis Research
- Neurogenetic and Muscular Disorders Research
- Cholinesterase and Neurodegenerative Diseases
- Extracellular vesicles in disease
- Neuroinflammation and Neurodegeneration Mechanisms
- Retinal Diseases and Treatments
- Botany and Plant Ecology Studies
- Metabolism, Diabetes, and Cancer
- Parkinson's Disease Mechanisms and Treatments
- Bryophyte Studies and Records
- Retinal Development and Disorders
- Glaucoma and retinal disorders
- Pancreatic function and diabetes
- Corneal surgery and disorders
- Lichen and fungal ecology
- Diabetes Treatment and Management
- Synthetic Organic Chemistry Methods
- Biochemical Acid Research Studies
- Acupuncture Treatment Research Studies
- Neuroscience and Neuropharmacology Research
- Complement system in diseases
- Diabetes Management and Research
- Diabetes and associated disorders
- Salivary Gland Disorders and Functions
- Olfactory and Sensory Function Studies
German Center for Neurodegenerative Diseases
2020-2025
Hertie Institute for Clinical Brain Research
2020-2025
University of Tübingen
2020-2025
University of Genoa
2017-2023
University of Palermo
2009-2018
University of Padua
1996
Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease with no effective cure. Astrocytes display toxic phenotype in ALS and contribute to motoneuron (MN) degeneration. Modulating astrocytes' neurotoxicity can reduce MN death. Our previous studies showed the beneficial effect of mesenchymal stem cell (MSC) administration SOD1G93A mice, but mechanisms are still unclear. We postulated that effects could be mediated by extracellular vesicles (EVs) secreted MSCs. investigated,...
Abstract The C9orf72 hexanucleotide repeat expansion mutation is the most common genetic cause of amyotrophic lateral sclerosis (ALS) and frontotemporal dementia, but its cell type-specific effects on energy metabolism immune pathways remain poorly understood. Using induced pluripotent stem (iPSC)-derived motor neurons, astrocytes microglia from patients their isogenic controls, we investigated metabolic changes at single-cell level under basal inflammatory conditions. Our results showed...
1. Andreaea flexuosa R.Br.bisContributor: H. Bednarek-OchyraChile: Isla Grande de Tierra del Fuego: Alberto Agostini National Park, Monte Buckland, towering over a narrow peninsula between Agost...
Abstract Amyotrophic lateral sclerosis is an adult‐onset neurodegenerative disease that develops because of motor neuron death. Several mechanisms occur supporting neurodegeneration, including mitochondrial dysfunction. Recently, we demonstrated the synaptosomes from spinal cord SOD1 G93A mice, in vitro model presynapses, displayed impaired metabolism at early pre‐symptomatic stages disease, whereas perisynaptic astrocyte particles, or gliosomes, were characterized by mild energy impairment...
The pathogenesis of amyotrophic lateral sclerosis (ALS) is not fully clarified, although excessive glutamate (Glu) transmission and the downstream cytotoxic cascades are major mechanisms for motor neuron death. Two metabotropic receptors (mGlu1 mGlu5 ) overexpressed in ALS regulate cellular disease processes. Expression function altered at early symptomatic stages SOD1G93A mouse model knockdown mice improved progression.We treated male female with...
Age-related macular degeneration (AMD) is a complex degenerative disease of the retina with multiple risk-modifying factors, including aging, genetics, and lifestyle choices. The combination these factors leads to oxidative stress, inflammation, metabolic failure in retinal pigment epithelium (RPE) subsequent photoreceptors retina. alternative complement pathway tightly linked AMD. In particular, genetic variant factor H gene (CFH), which Y402H polymorphism protein (FH), confers second...
Glutamate (Glu)-mediated excitotoxicity is a major cause of amyotrophic lateral sclerosis (ALS) and our previous work highlighted that abnormal Glu release may represent leading mechanism for excessive synaptic Glu. We demonstrated group I metabotropic receptors (mGluR1, mGluR5) produced in SOD1G93A mouse spinal cord at late disease stage (120 days). Here, we studied this phenomenon pre-symptomatic (30 60 days) early-symptomatic (90 mice. The mGluR1/5 agonist (S)-3,5-Dihydroxyphenylglycine...
Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease characterized by progressive degeneration of motor neurons (MNs). Astrocytes display toxic phenotype in ALS, which results MN damage. Glutamate (Glu)-mediated excitotoxicity and group I metabotropic glutamate receptors (mGluRs) play pathological role the progression. We previously demonstrated that vivo genetic ablation or pharmacological modulation mGluR5 reduced astrocyte activation death, prolonged survival...
This study evaluated the predictors of effectiveness and durability insulin pump therapy in children adolescents who have initiated continuous subcutaneous infusion (CSII) within 2 years after diagnosis type 1 diabetes mellitus (T1DM).The charts individuals with T1DM using pumps were treated at our center reviewed, including subjects age onset <22 years, interval between commencement (interval onset-commencement) <2 use >1 year, glucose sensors for <4 weeks/year. The primary end point was...
Introduction . This study aimed at evaluating the efficacy and safety of dapagliflozin in patients with type 2 diabetes (T2D) who also received metformin clinical practice Italy. Methods was a retrospective observational it included data from 10 mg once daily conjunction for 12 months (DAPA + MET). In those inadequate glycemic control, insulin or glimepiride added after 30 days MET other glucose-lowering drugs). Efficacy assessments glycosylated hemoglobin (HbA 1c ) levels 6 months, as well...
Abstract Sicilian epiphytic bryophyte diversity, based on literature and unpublished data, is assessed both quantitatively qualitatively. The total number of taxa found trees or shrubs 133 (116 mosses 17 liverworts). Among them, 38 are customary epiphytic, 21 cortico‐saxicolous, 13 indifferent 61 occasionally taxa. most represented families Orthotrichaceae (19.1%), which consists above all several typically corticicolous species, Pottiaceae (19.1%) Brachytheciaceae (12.6%) include many that...
Abstract Age-related macular degeneration (AMD) is a complex degenerative disease of the retina with multiple risk-modifying factors, including ageing, genetics and lifestyle choices. The combination these factors leads to oxidative stress, inflammation metabolic failure in retinal pigment epithelium (RPE) subsequent photoreceptors retina. alternative complement pathway tightly linked AMD. In particular, genetic variant factor H gene ( CFH ), that Y402H polymorphism protein (FH), confers...
Background Acupuncture is a therapeutic technique currently used in the treatment of many pathologies. The aim this study to evaluate potential effect acupuncture on “in vivo” variations oral microcirculation healthy subjects. Methods An exploratory was conducted 40 subjects: 20 cases (mean 55.90, SD 16.04) and controls 51, 11.91). Videocapillaroscopy detect microcirculation. This method permits an accurate non-invasive vivo capillaries mucous. site selected for pilot lower lip since it...
Biogeographia vol. )OOl - 2011 (Pubblicato il 23 dicembre 2011) La Biogeografia della Sicilia Nuove stazioni in di Pemlopkyllum mlfiii (Hepatophyta), specie minacciata Europa, e altre briofite rare Italia meridionale FIORENZA PROVENZANO, MARIA GIOVANNA DIA, PATRIZIA CAMPISI Dzfartimento Biologia Ambientzzle Biodiversitzi, Universitzi degli Studi Palermo, via Arc/aimfi 38, 90123 Palermo (Italy); e—maz'l: m. gz'owznna.dz'a@unz'pa. it Key words: Bryophytes, Sicily, Pemlop/ayllum,...