Roberta Chianetta
A5017990681- Diabetes Treatment and Management
- Metabolism, Diabetes, and Cancer
- Diet, Metabolism, and Disease
- Diabetes Management and Research
- Nutritional Studies and Diet
- Nutrition, Genetics, and Disease
- Pharmacology and Obesity Treatment
- Diet and metabolism studies
- Antioxidant Activity and Oxidative Stress
- Pancreatic function and diabetes
- Lipoproteins and Cardiovascular Health
- Pharmacological Effects of Natural Compounds
- Natural Antidiabetic Agents Studies
- Cynara cardunculus studies
- MicroRNA in disease regulation
- Cholesterol and Lipid Metabolism
- Consumer Attitudes and Food Labeling
- Circular RNAs in diseases
- Medical and Biological Ozone Research
- Liver Disease and Transplantation
- Paraoxonase enzyme and polymorphisms
- Blood Pressure and Hypertension Studies
- Statistical Methods in Clinical Trials
- Biotin and Related Studies
- Herbal Medicine Research Studies
University of Palermo
2017-2025
Istituto Euro Mediterraneo di Scienza e Tecnologia
2017-2020
Metabolic syndrome (MetS) is characterized as a group of cardiometabolic risk factors that raise the for heart disease and other health problems, such diabetes mellitus stroke.Treatment strategies include pharmacologic interventions supplementary (or "alternative") treatments.Nutraceuticals are derived from food sources (isolated nutrients, dietary supplements herbal products) purported to provide benefits, in addition providing basic nutritional value.Nutraceuticals claimed prevent chronic...
The objective was to evaluate the effects of 6 months supplementation with Altilix®, containing chlorogenic acid and its derivatives, luteolin on cardiovascular risk hepatic markers in subjects metabolic syndrome (MetS). A randomized, double-blind, placebo-controlled study performed 100 MetS a follow-up period months; 50 were randomized Altilix® (26 men 24 women, mean age 63 ± 8 years) other placebo (28 22 11 years). Anthropometric, cardiometabolic, parameters assessed at baseline end...
Pre-obesity is a condition that predisposes to the risk of developing obesity, cardiovascular diseases (CVD), and diabetes. Our previous study demonstrated Cynara cardunculus (L.) based nutraceutical named Altilix® (Bionap, Italy), containing chlorogenic acid luteolin extracts, was able improve several hepatic cardio-metabolic parameters. Given this background, we conducted post-hoc analysis in order analyze supplement’s effects subgroup pre-obesity subjects on anthropometry (weight waist...
Liraglutide has shown favourable effects on several cardiometabolic risk factors, beyond glucose control. MicroRNAs (miRNAs) regulate gene expression, resulting in post-transcriptional modifications of cell response and function. Specific miRNAs, including miRNA-27b, miRNA-130a, miRNA-210, play a role disease. We aimed to determine the effect liraglutide serum levels miRNA-130a miRNA-210. Twenty-five subjects with type-2 diabetes mellitus (T2DM), naïve incretin-based therapy, were treated...
The glucagon-like peptide-1 agonist (GLP1-RA) liraglutide is currently approved for the treatment of both obesity and type 2 diabetes (T2DM). We investigated whether effect this agent on cardiometabolic parameters in subjects with T2DM varied relation to concomitant presence obesity. One hundred thirty-five (78 men 57 women; age: 62 ± 10 years) naïve incretin-based therapies were treated low-dose (1.2 mg/day) as an add-on metformin 18 months. Patients divided into two subgroups based their...
Appropriate monitoring and control of modifiable risk factors, such as the level low-density lipoprotein cholesterol (LDL-C) other types dyslipidemia, have an important role in prevention cardiovascular diseases (CVD). Recently, various nutraceuticals with lipid-lowering effects gained attention. In addition to plant-derived bioactive compounds, recent studies suggested that plant cells are able release small lipoproteic structures named extracellular vesicles (EVs). The interaction between...
Metabolic syndrome (MetS) is associated with cardiovascular risk factors, such as insulin resistance, dyslipidaemia, hypertension and abdominal obesity. Given the growing need to investigate food supplements positive health effects, this study was aimed at testing benefits of a specific supplement for people MetS. Fifty-eight subjects MetS T2DM or impaired glucose tolerance assuming metformin, were randomly assigned take glucomannan, D-chiro-inositol, Cinnamomum zeylanicum blume inulin daily...
DPP-4 inhibitors (DPP4i) and sulfonylureas are popular second-line therapies for type 2 diabetes (T2D), but there is a paucity of real-world studies comparing their effectiveness in routine clinical practice. This was multicenter retrospective study on outpatient clinics the DPP4i versus gliclazide extended release. The primary endpoint change from baseline HbA1c. Secondary endpoints were changes fasting plasma glucose, body weight, systolic blood pressure. Automated software extracted data...
Abstract Aim To compare effectiveness of dapagliflozin versus DPP-4 inhibitors on individualized HbA1c targets and extra-glycaemic endpoints among elderly patients with type 2 diabetes (T2D). Methods This was a multicentre retrospective study aged 70–80 years above target starting or in 2015–2017. The primary outcome the proportion reaching targets. Confounding by indication addressed inverse probability treatment weighting (IPTW), multivariable adjustment (MVA), propensity score matching...
Abstract Objective This randomized controlled trial examined the efficacy of adding a fasting‐mimicking diet to structured psychotherapy protocol for treating depression. Design Of 20 patients with depression, 10 were randomly assigned and dieting (i.e., experimental group) other only control group). Patients in both groups received individual sessions functional therapy along nutrition consultation. group instructed maintain their usual daily diets. Results Both treatments effective...
Transferring results obtained in cardiovascular outcome trials (CVOTs) to the real-world setting is challenging. We herein transposed CVOT population of patients with type 2 diabetes (T2D) seen routine clinical practice and who may receive medications tested CVOTs.We implemented post-stratification approach based on aggregate data CVOTs individual a target diabetic outpatients. used stratum-specific estimates available from calculate expected effect size for by weighting average treatment...
Searchable abstracts of presentations at key conferences in endocrinology ISSN 1470-3947 (print) | 1479-6848 (online)