A5055764247- Neuropeptides and Animal Physiology
- Diabetes Treatment and Management
- Nitric Oxide and Endothelin Effects
- Gastrointestinal motility and disorders
- Diet and metabolism studies
- Receptor Mechanisms and Signaling
- Adenosine and Purinergic Signaling
- Ion channel regulation and function
- Muscle Physiology and Disorders
- Pancreatic function and diabetes
- Ion Channels and Receptors
- Viral Infections and Immunology Research
- Pain Mechanisms and Treatments
- Regulation of Appetite and Obesity
- Neuroscience of respiration and sleep
- Adipose Tissue and Metabolism
- Alzheimer's disease research and treatments
- Adrenal Hormones and Disorders
- Neuroendocrine regulation and behavior
- Gastroesophageal reflux and treatments
- Biochemical Analysis and Sensing Techniques
- Neuroscience and Neuropharmacology Research
- Cannabis and Cannabinoid Research
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Phytochemicals and Antioxidant Activities
University of Palermo
2016-2025
Institute of Cell Biology and Neurobiology
1985-2010
University of Calabria
1999-2002
Istituto di Fisiologia Clinica
1982
Alzheimer's disease (AD) is an aging-related multi-factorial disorder to which metabolic factors contribute at what has canonically been considered a centrally mediated process. Although the exact underlying mechanisms are still unknown, obesity recognized as risk factor for AD and condition of insulin resistance seems be link between two pathologies. Using mice with high fat diet (HFD) we dissected molecular shared by disorders. Brains HFD fed showed elevated levels APP Aβ40/Aβ42 together...
High-fat diet (HFD) induces inflammation and microbial dysbiosis, which are components of the metabolic syndrome. Nutritional strategies can be a valid tool to prevent inflammatory diseases. The aim present study was evaluate if chronic intake pistachio prevents obesity-associated dysbiosis in HFD-fed mice. Three groups male mice (four weeks old; n = 8 per group) were fed for 16 with standard (STD), HFD, or HFD supplemented pistachios (HFD-P; 180 g/kg HFD). Serum, hepatic adipose tissue...
Pre-obesity is a condition that predisposes to the risk of developing obesity, cardiovascular diseases (CVD), and diabetes. Our previous study demonstrated Cynara cardunculus (L.) based nutraceutical named Altilix® (Bionap, Italy), containing chlorogenic acid luteolin extracts, was able improve several hepatic cardio-metabolic parameters. Given this background, we conducted post-hoc analysis in order analyze supplement’s effects subgroup pre-obesity subjects on anthropometry (weight waist...
Non-alcoholic fatty liver disease (NAFLD) confers an increased risk of cardiovascular diseases. NAFDL is associated with atherogenic dyslipidemia, inflammation and renin-angiotensin system (RAS) imbalance, which in turn lead to atherosclerotic lesions. In the present study, impact a natural dietary supplement (NDS) containing Curcuma longa, silymarin, guggul, chlorogenic acid inulin on NAFLD atherosclerosis was evaluated, mechanism action examined. C57BL/6 mice were fed HFD for 16 weeks;...
Endogenous glucagon-like peptide-2 (GLP2) is a key mediator of refeeding-induced and resection-induced intestinal adaptive growth. This study investigated the potential role GLP2 in mediating mucosal responses to chronic high-fat diet (HFD). In this view, murine small intestine response HFD was analyzed possible involvement endogenous verified using (3-33) as receptor (GLP2R) antagonist. comparison with animals fed standard diet, mice for 14 weeks exhibited an increase crypt-villus mean...
Aging | doi:10.18632/aging.101004. Pasquale Picone, Silvia Vilasi, Fabio Librizzi, Marco Contardi, Domenico Nuzzo, Luca Caruana, Sara Baldassano, Antonella Amato, Flavia Mulè, Pier Luigi San Biagio, Daniela Giacomazza, Marta Di Carlo
Obesity has been associated with neurodegeneration and cognitive dysfunctions. Recent data showed that pistachio consumption is able to prevent ameliorate dyslipidemia, hepatic steatosis, systemic adipose tissue inflammation in mice fed a high-fat diet (HFD). The present study investigated the neuroprotective effects of intake HFD mice. Three groups were standard (STD), HFD, or supplemented (HFD-P) for 16 weeks. Metabolic parameters (oxidative stress, apoptosis, mitochondrial dysfunction)...
Metabolic disorders and brain insulin resistance (IR) are major risk factors for the development of neurodegenerative conditions. Kumquat fruit (KF) administration has demonstrated significant anti-dysmetabolic effects, improving peripheral IR in murine models metabolic syndrome. Along these lines, this study evaluated neuroprotective effects KF supplementation a model dysmetabolism-induced neuronal damage its ability to counteract disruption signalling. To end, biochemical histological...
Glucagon like peptide-2 (GLP-2) is a gastrointestinal hormone released in response to dietary nutrients, which acts through specific receptor, the GLP-2 receptor (GLP-2R). The physiological effects of are multiple, involving also intestinal adaptation high fat diet (HFD). In consideration well-known relationship between chronic HFD and impaired glucose metabolism, present study we examined if blocking signaling by treatment with GLP-2R antagonist, (3-33), leads functional consequences...
Obesity and metabolic disorders can be risk factors for the onset development of neurodegenerative diseases. The aim present study was to investigate protective effects a natural dietary supplement (NDS), containing Curcuma longa, silymarin, guggul, chlorogenic acid inulin, on dysmetabolism neurodegeneration in brains high fat diet (HFD)-fed mice. Decrease expression FACL-4, CerS-1, CerS-4, cholesterol concentration increase insulin receptor signaling activation, were found NDS-treated HFD...
Glucagon-like peptide-2 (GLP-2) influences different aspects of the gastrointestinal function, including epithelial growth, digestion, absorption, motility, and blood flow. Intraluminal pressure from isolated mouse stomach was recorded to investigate whether GLP-2 affects gastric tone analyze its mechanism action. Regional differences between diverse parts were also examined using circular muscular strips fundus antrum. In whole stomach, (0.3-100 nM) produced concentration-dependent...
Glucagon-like peptide-2 (GLP-2) is an important neuroendocrine peptide in intestinal physiology. It influences digestion, absorption, epithelial growth, motility, and blood flow. We studied involvement of GLP-2 mucosal secretory behavior. Submucosal-mucosal preparations from guinea pig ileum were mounted Ussing chambers for measurement short-circuit current ( I sc ) as a surrogate chloride secretion. action on neuronal release acetylcholine was determined with ELISA. Enteric expression the...
Duchenne muscular dystrophy (DMD), which results from deficiency in dystrophin, a sarcolemma protein of skeletal, cardiac and smooth muscle, is characterized by progressive striated muscle degeneration, but various gastrointestinal clinical manifestations have been observed. The aim was to evaluate the possible impact dystrophin loss on propulsion mdx mice (animal model for DMD). gastric emptying carboxymethyl cellulose/phenol red dye non-nutrient meal not significantly different at 20 min...
Abstract Background Glucagon‐like peptide 2 (GLP‐2), a nutrient‐responsive hormone, exerts various actions in the gastrointestinal tract that are mediated by G‐protein coupled receptor called GLP‐2R. A little information is available on GLP‐2R expression enteric neurons and nothing interstitial cells of Cajal (ICC). Methods We investigated presence distribution mouse duodenum immunohistochemistry potential motor effects GLP‐2 spontaneous neurally evoked mechanical activity. Key Results The...