A5005309085- Pituitary Gland Disorders and Treatments
- Meningioma and schwannoma management
- Head and Neck Surgical Oncology
- Cerebrospinal fluid and hydrocephalus
- Glioma Diagnosis and Treatment
- Growth Hormone and Insulin-like Growth Factors
- Neurosurgical Procedures and Complications
- Neurofibromatosis and Schwannoma Cases
- Adrenal and Paraganglionic Tumors
- Sinusitis and nasal conditions
- Vascular Malformations Diagnosis and Treatment
- Intracranial Aneurysms: Treatment and Complications
- Teratomas and Epidermoid Cysts
- Assisted Reproductive Technology and Twin Pregnancy
- Electrolyte and hormonal disorders
- Myasthenia Gravis and Thymoma
- Spinal Fractures and Fixation Techniques
- Intestinal Malrotation and Obstruction Disorders
- Cleft Lip and Palate Research
- Neuroblastoma Research and Treatments
- Infectious Diseases and Tuberculosis
- Craniofacial Disorders and Treatments
- Management of metastatic bone disease
- Bone Tumor Diagnosis and Treatments
- Retinal and Macular Surgery
Burdenko Neurosurgery Institute
2015-2025
Ministry of Health of the Russian Federation
2018-2025
Background. The term “aggressive pituitary adenoma” arose as a result of transforming the “atypical adenoma”, which was used in WHO classification for adenomas with specifications higher labeling index Ki-67 (≥3 %) and increased number mitoses expression p53 proteins. However, not all tumors these features were aggressive, currently, according to European Society Endocrinology Clinical Practice Guideline management aggressive carcinomas (2018), are labeled that have invasive unusually rapid...
Primary hypophysitis is a rare disease that usually diagnosed retrospectively after surgery for suspected tumors of the sellar region (pituitary adenomas, craniopharyngiomas, etc.). The most common variant primary forms lymphocytic hypophysitis, characterized by presence lymphocytes in inflammatory infiltrate. Granulomatous second disease, cause which remains unknown. Objective. To study frequency and nature clinical manifestations, features MRI brain, as well results neurosurgical treatment...
One of the most serious/potentially fatal complications transsphenoidal surgery (TSS) is internal carotid artery (ICA) injury. Of 6230 patients who underwent TSS, ICA injury occurred in 8 (0.12%). The etiology, possible treatment options, and avoidance were analyzed. at two different stages: (1) during exposure sella floor dural incision over cavernous sinus (2) resection extension tumor. angiographic collateral blood supply was categorized as good, sufficient, nonsufficient to help with...
Pituitary adenomas are benign growths that invade the cavernous sinus (CS) in 10-15% of cases. There different types microsurgical and endoscopic approaches enabling resection tumors from CS cavity is a relatively small hard to reach anatomical structure comprising eloquent neurovascular structures.A study group included 97 patients with pituitary (PAs) invading CS. PAs were resected using an technique: through standard endonasal transsphenoidal approach 62 cases; lateral extended was used...
Thyrotropinomas (TSH-secreting tumors) are a rare type of pituitary adenomas, which account for about 0.5-2.0% all tumors. The criterion thyrotropinoma is visualization the tumor in presence normal or elevated level thyroid-stimulating hormone (TSH) blood and concentrations free T4 (fT4) T3 (fT3).To study clinical, diagnostic, morphological characteristics treatment outcomes TSH-secreting tumors.The included 21 patients aged from 15 to 67 years with adenoma TSH combined fT4 fT3 levels who...
At present, pharmacological therapy of prolactinomas with dopamine agonists (DAs) is considered the treatment choice. In most cases, giant respond to and decrease in size during first months treatment. One rare but dangerous complications conservative invasive growth cerebrospinal fluid rhinorrhea.We present a retrospective analysis 15 patients macropropactinomas who underwent surgery for rhinorrhea developed due primary at Burdenko Neurosurgical Institute (BNI) period between 2005 2015. All...
Doppler ultrasound (DUS) has been widely used in neurosurgical practice to diagnose various cerebrovascular diseases. This technique is transsphenoidal surgery identify the localization of intracranial arteries when making an approach or during tumor resection.To cavernous segment internal carotid artery (ICA) and/or basilar endoscopic surgery, we a combined device on basis click line curette («Karl Storz») and 16 MHz probe (Lassamed). The was 51 patients both standard (23 cases) resection...
The structure of surgery pituitary adenomas has been fundamentally changed over the past decade. transnasal transsphenoidal approach is currently used to resect more than 95% adenomas. wide use endoscopy need for perioperative control intracranial pressure. While controlled hypertension was previously during microscopically bring suprasellar capsule and tumor remnants field vision, endoscopically resection implies that hypotension required achieve complete spreading capsule. External lumbar...
The pituitary stalk (PS) is a relatively thin bundle connecting the hypophyseal to gland; it consists of both axons hypothalamic nuclei (terminating in neurohypophysis) and system portal vessels. Compression PS by space-occupying lesion or its transection (forced intended) during surgery may lead development endocrine disorders: hypopituitarism, diabetes insipidus, hyperprolactinemia. modern literature lacks studies evaluating severity disorders depending on condition before after...
Optochiasmatic cavernoma is an extremely rare cerebral lesion. They account for approximately 1% of all cavernomas the central nervous system. Reports on this pathology are limited. Abrupt visual deterioration a common symptom disease. Treatment strategy and outcomes after different treatment approaches remain subject discussion.
Surgery of suprasellar meningiomas is a challenge and associated with high risk injury to the vascular-neural structures lying along approach surrounding tumor. Currently, many foreign clinics our Center have introduced technique for resection through anterior extended transsphenoidal endoscopic endonasal approach.The study objective was evaluate role approaches in surgery meningiomas.The present retrospective analysis surgical treatment outcomes 45 patients (11 males 34 females aged 23 70...
The study is devoted to the use of a minimally invasive method SCT perfusion for differential diagnosis sellar and pаrаsellar tumors. Given wide diagnostic range tumors occurring in this area, tumor indicators were used as an auxiliary criterion.The analyzed outcomes 115 patients with various area who underwent surgery or biopsy histological verification diagnosis.The statistically significant differences obtained certain groups based on values hemodynamic parameters (p<0.05) that enable,...
to describe the main topographic and anatomical features of clival region its adjacent structures for improvement optimization extended endoscopic endonasal posterior (transclival) approach resection tumors ventral cranial fossa.We performed a craniometric study 125 human skulls heads 25 cadavers, arterial venous bed which was stained with colored silicone (the staining technique developed by authors) visualize individual variability. Currently, we have clinical material from more than 120...
The paper summarizes the experience in using a system of electromagnetic intraoperative frameless navigation various neurosurgical pathologies brain. technique was used for 102 operations 98 patients, including 36 transnasal endoscopic interventions. There were no intraoprtative and postoperative complications associated with use system. In process system, factors influencing accuracy requiring additional control by surgeon identified.The study purpose to evaluate surgical treatment patients...
Background. Cavernoma of cavernous sinus is a fairly rare benign neoplasm, accounting for less than 3 % all neoplasms in this area. Due to the rarity pathology, standardized protocol diagnosis or treatment has not been developed. Surgical and radiosurgical methods are used treatment. Aim. Analysis results patients with cavernomas operated at N. Burdenko National Medical Research Center Neurosurgery from 2000 2022 using endoscopic transnasal access. Materials methods. We present our own...
Introduction The tumors of the diencephalon region (thalamic-hypothalamic-pituitary system) include a large group: pituitary adenomas, craniopharyngiomas, gliomas, and others. Tumors differ in histological structure, manifestations clinical symptoms; by hormonal data; approaches methods treatment. Psychic symptoms are revealed disease addition to cerebral, neuroendocrine symptoms, neurological disorders. Psychoorganic syndrome is represented emotional, motivational, personal, cognitive...
The article presents an original method for personalized predicting surgical outcomes in patients with tumors of diencephalic and suprasellar localization based on a clinical epidemiological approach the use intelligent analysis (Data Mining) electroencephalo-graphic data. Use methods allowed us to programmatically select nosologically specific test making outcome prognosis, including sensitivity specificity calculations.