A5046514051- Brucella: diagnosis, epidemiology, treatment
- Monoclonal and Polyclonal Antibodies Research
- HIV-related health complications and treatments
- Trypanosoma species research and implications
- Galectins and Cancer Biology
- Genital Health and Disease
- Iron Metabolism and Disorders
- Immunotherapy and Immune Responses
- HIV Research and Treatment
- Research on Leishmaniasis Studies
- Cervical Cancer and HPV Research
- Viral Infections and Vectors
- HIV/AIDS drug development and treatment
- Reproductive tract infections research
- Bipolar Disorder and Treatment
- Tryptophan and brain disorders
- Child Nutrition and Water Access
- interferon and immune responses
- HIV/AIDS Research and Interventions
- Bacteriophages and microbial interactions
- Vector-borne infectious diseases
- Systemic Lupus Erythematosus Research
- Olfactory and Sensory Function Studies
- Parasites and Host Interactions
- Regulation of Appetite and Obesity
Centro Médico Nacional La Raza
2015-2024
Mexican Social Security Institute
2013-2024
Hospital de Especialidades
2024
National Council of La Raza
2022
Instituto Politécnico Nacional
2003-2018
Tecnológico Nacional de México
2017
Navarre Institute of Health Research
2016
Centro Medico Nacional Siglo XXI
2013
Journal Article Antigen-specific activation and proliferation of CD4+ CD8+ T lymphocytes from brucellosis patients Get access Martha Cecilia Moreno-Lafont, Moreno-Lafont 1Departamento de Inmunología, Escuela Nacional Ciencias Biológicas, I.P.N. Colonia Santo Tomás, 11340, México D.F., Mexico4Departamento Biomedicina Molecular, CINVESTAV, Av. IPN No. 2508 Col. Zacatenco, 07360 México, Mexico Search for other works by this author on: Oxford Academic PubMed Google Scholar Rubén López-Santiago,...
Scavenger receptor class B type I (SR-B1) binds pathogen-associated molecular patterns participating in the regulation of inflammatory reaction but there is no information regarding potential interactions between SR-B1 and interferon system. Herein, we report that ligands strongly regulate transcriptional response to α (IFNα) enhance its antiviral antitumor activity. This effect was mediated by activation TLR2 TLR4 as it annulled addition anti-TLR2 or anti-TLR4 blocking antibodies. In vivo,...
// Marcos Vasquez 1 , Vladimir Paredes-Cervantes 1, 2 Fernando Aranda Nuria Ardaiz Celia Gomar Pedro Berraondo Program of Immunology and Immunotherapy, Center for Applied Medical Research (CIMA), Navarra Institute Health (IdiSNA), Pamplona, Navarra, Spain Centro Médico Nacional La Raza, IMSS, México DF, Mexico Correspondence to: Berraondo, email: pberraondol@unav.es Keywords: colorectal cancer, liver metastasis, cancer immunotherapy, T regulatory cells, PD-1 Received: June 09, 2016 Accepted:...
CD8 + T cells that secrete proinflammatory cytokines play a central role in exacerbation of inflammation; however, new subpopulation regulatory has recently been characterized. This study analyzes the prominent these different subpopulations development graft-versus-host disease (GVHD). Samples from 8 healthy donors mobilized with Filgrastim® (G-CSF) and 18 patients who underwent allogeneic hematopoietic stem cell transplantation (HSCT) were evaluated by flow cytometry. Mobilization induced...
Most HIV-antiretroviral drugs have adverse effects. Efavirenz (EFV) is an example of a drug with neuropsychiatric effects, such as anxiety, depression, and suicidal thoughts, in people living HIV (PLWH). The mechanisms by which EFV causes alterations PLWH are complex, multifactorial, not fully understood, although several studies animals reported changes brain energy metabolism, monoamine turnover, GABA, glutamate levels, 5-HT receptors. In this report, we studied the effects on serotonergic...
(1) Background: Chagas disease is the main neglected tropical in America. It estimated that around 6 million people are currently infected with parasite Latin America, and 25 live endemic areas active transmission. The causes an economic loss of USD 24 billion dollars annually, a 75,200 working years per year life; it responsible for ~12,000 deaths annually. Although Mexico country recorded 10,186 new cases during period 1990–2017, few studies have evaluated genetic diversity genes could be...
Abstract. Establishing the safety of non-caloric sweetener consumption in humans is a difficult task, since many contradictory results have been reported. The objective this study was to compare effect frequent intake sucrose, sucralose or steviol glycosides, on selected anthropometric, biochemical and immunological parameters healthy, young adults. 38 individuals with normal body mass index were recruited randomly divided into three experimental groups. After washout week (where food added...
Leprosy is an infectious disease caused by Mycobacterium leprae, which a noncultivable bacterium. One of the principal goals leprosy research to develop serological tests that will allow identification and early treatment patients. M. habana cultivable nonpathogenic mycobacterium candidate vaccine for leprosy, several antigens cross-react between leprae have been discovered. The aim present study was extend cross-reactive identifying proteins reacted immunoblotting with antibodies in serum...
The CatSper channel localizes exclusively in the flagella of sperm cells. Catsper1 protein, together with three pore units, is essential for Channel formation, which produces flagellum hyperactivation and confers fertility. expression dependent on Sox transcription factors, can recognize vitro at least binding sites promoter. factors have calmodulin-binding domains nuclear importation. Calmodulin (CaM) affected by specific inhibitor calmidazolium (CMZ), prevents transport factors. In this...
BACKGROUND Trypanosoma cruzi is a protozoan parasite that causes Chagas disease endemic to Latin‐America. It estimated 1.0 1.5% of Mexicans are infected with T. cruzi, which constitutes potential risk transmission via contaminated blood. New cases being reported worldwide due the migration people from areas. STUDY DESIGN AND METHODS Serum samples were collected donors at Central Blood Bank National Medical Center “La Raza” July 2008 December 2015 and analyzed for antibodies using...
Abstract Tryptophan hydroxylase type 2 (Tph2) is the rate-limiting enzyme for serotonin (5-HT) biosynthesis in brain. Dysfunctional Tph2 alters 5-HT biosynthesis, leading to a deficiency of 5-HT, which could have repercussions on human behavior. In last decade, several studies associated polymorphisms TPH2 gene with suicidal Additionally, has been implicated various psychiatric pathologies, including alcoholism, impulsive behavior, anxiety, and depression. Therefore, be an ideal target...
Organotin compounds are man-made chemicals used worldwide for diverse applications. These organometallic may be released from antifouling paints, polyvinyl chloride and other materials into terrestrial aquatic environments. Mexico City is a highly populated industrialized city with many potential sources of environmental pollution. We evaluated the content butyltins, triphenyltin bacteria in water various sites different quality City, Pachuca two towns located between these cities. Butyltins...
Efavirenz (EFV) causes neuropsychiatric effects such as anxiety, depression, and suicidal thoughts in people with HIV (PWH). Depressive disorders have been associated the Tryptophan hydroxylase type 2 (TPH2) gene. Objectives: This study determines genotypes allelic frequencies of three TPH2 single nucleotide polymorphisms (SNPs) a Mexican cohort HIV-1 treatment-naïve-patients severity depressive symptoms at baseline after four-week clinical follow-up antiretroviral treatment. Methods: In...
Abstract It has been demonstrated that Brucella abortus is capable to multiply into professional antigen presenting cells such as macrophages and dendritic cells. However, there are a few reports about infection B In this work, we evaluated the ability of B. 2308 for infect human cell line, NALM6 R. cultured in RPMI medium supplied with L-glutamine 10% fetal calf serum were infected several MOIs transformed by electroporation pBBR1MCS-2-gfp-mut3 plasmid evaluate entry green fluorescent...
Abstract Background Depressive disorders have been associated with TPH2 gene polymorphisms. Additionally, HIV-1 antiretroviral drugs (ART) such as efavirenz (EFV) reported to cause neuropsychiatric adverse effects. Objective This study aimed determine the genotypes and allelic frequencies of SNPs (rs120074175, rs1386493, rs4570625, rs7305115) in a Mexican cohort ART-naive patients, healthy volunteers control, assess severity their depressive symptoms using Beck Depression Inventory (BDI)....
Iron is an essential nutrient for many metabolic processes, which include erythropoiesis, oxidative metabolism and the immune response. deficiency (ID) considered a worldwide public health problem. The objective of this study was to determine prevalence ID its effects on production proinflammatory cytokines (TNF‐α INF‐γ) in 8 12 year‐old children from community State Mexico. Blood samples were obtained 100 children; weight height also measured. Serum used iron concentrations by...
Abstract Cu/Zn superoxide dismutase (SOD), located in the periplasmic space of cell wall Brucella abortus, induces protective mediated immunity mice challenged with virulent strains. In vitro studies have shown that SOD proliferation splenocytes, antibody production and T cytotoxicity. humans, recombinant (rSOD) is recognized by serum patients chronic brucellosis. order to prove rSOD immunogenicity humans brucellosis, we cloned coding sequence gene sodC from B. abortus RB51 into an...