A5070723572- Tryptophan and brain disorders
- Stress Responses and Cortisol
- Neuroinflammation and Neurodegeneration Mechanisms
- Fibromyalgia and Chronic Fatigue Syndrome Research
- Bipolar Disorder and Treatment
- Neurotransmitter Receptor Influence on Behavior
- Brucella: diagnosis, epidemiology, treatment
- Circadian rhythm and melatonin
- S100 Proteins and Annexins
- Monoclonal and Polyclonal Antibodies Research
- Neurogenesis and neuroplasticity mechanisms
- Receptor Mechanisms and Signaling
- Hedgehog Signaling Pathway Studies
- Sleep and Wakefulness Research
- Vagus Nerve Stimulation Research
- Virus-based gene therapy research
- Neuroendocrine regulation and behavior
- Nicotinic Acetylcholine Receptors Study
- Pharmacological Effects of Natural Compounds
- Neuroscience and Neuropharmacology Research
- Epigenetics and DNA Methylation
- HIV/AIDS Research and Interventions
- Musculoskeletal pain and rehabilitation
- Respiratory viral infections research
- Protein purification and stability
Instituto Nacional de Psiquiatría
2015-2025
Instituto Politécnico Nacional
2011-2018
Center for Research and Advanced Studies of the National Polytechnic Institute
2015-2018
Tecnológico Nacional de México
2015
Changes in cytokine levels major depression and during treatment have been reported adults. However, few studies examined an adolescent sample despite this being a common age of onset. Methods . We measured proinflammatory (IL-2, IFN- γ , IL-1 β TNF- α IL-6, IL-12, IL-15) anti-inflammatory (IL-4, IL-5, IL-13, IL-1Ra, IL-10) serum 22 adolescents with 18 healthy volunteers. Cytokines were by multiplex bead-based immunoassays at baseline, 4 8 weeks after commencement fluoxetine administration...
Major depressive disorder (MDD) has a prevalence of 5% in adolescents. Several studies have described the association between inflammatory response and MDD, but little is known about relationship MDD growth factors, such as IL-7, IL-9, IL-17A, VEGF, basic FGF, G-CSF, GM-CSF. It must be appointed that there are scarce reports on factors adolescents with even fewer clinical follow-up. In this work, we evaluated levels (IL-7, GM-CSF) follow-up during eight weeks treatment fluoxetine. Methods ....
Dopamine and serotonin receptors transporters play an essential role in the pathophysiology of schizophrenia; changes their expression have been reported neurons leukocytes. Each antipsychotic induces a unique pattern leukocyte function phenotype. However, use polytherapy to treat schizophrenia makes it challenging determine specific effects risperidone on peripheral blood mononuclear cells (PBMCs). The aim this study was evaluate D3, D5, DAT, 5-HT2A, SERT PBMCs from healthy volunteers (HV),...
Human dialyzable leukocyte extracts (DLEs) are heterogeneous mixtures of low-molecular-weight peptides that modulate immune responses in various diseases. Due their complexity, standardized methods to identify physicochemical properties and determine production batches biologically active must be established. We aimed develop validate a size exclusion ultra performance chromatographic (SE-UPLC) method characterize Transferon™, DLE is produced under good manufacturing practices (GMPs)....
Tuberculosis (TB) is a chronic infectious disease in which prolonged, non-resolutive inflammation of the lung may lead to metabolic and neuroendocrine dysfunction. Previous studies have reported that individuals coursing pulmonary TB experience cognitive or behavioural changes; however, pathogenic substrate such manifestations remained unknown. Here, using mouse model progressive TB, we report that, even absence brain infection, associated with marked increased synthesis both inflammatory...
Brucellosis is an infection widely distributed around the world, and in some countries it considered a public health problem. causes insidious symptoms that make difficult to diagnose. Infection can also trigger chronic pain neuropsychiatric complications. Antibiotics are not always effective eradicate infection, contributing chronicity. We aimed investigate effects of antibiotic treatment on proinflammatory cytokines, neurotransmitters, corticosterone, behavior murine model infecrion B....
Fibromyalgia (FM) is a chronic condition that causes widespread pain, fatigue, and other symptoms significantly affect quality of life. The underlying mechanisms fibromyalgia involve both the immune system central nervous system. It has been proposed changes in multiple ascending descending pathways may contribute to increased pain sensitivity individuals with this condition. Recent research identified S100 proteins as new area interest studies. These are group small molecular weight...
Major depressive disorder (MDD) is a global health issue that affects 350 million people of all ages. Although between 2% and 5.6% affected individuals are adolescents, research on young patients limited. The inflammatory response contributes to the onset depression, in adult MDD patients, symptom severity has been linked chemokine levels.To determine differences circulatory levels chemokines healthy volunteers (HVs) adolescents with MDD, assess changes induced by fluoxetine consume.The 22...
The most widely prescribed antidepressant, fluoxetine (FLX), is known for its antioxidant and anti-inflammatory effects when administered post-stress. Few studies have evaluated the of FLX treatment chronic stress has induced deleterious in patients. Our objective was to evaluate (20 mg/kg/day, i.v.) once these are manifested, drug's relation extracellular circulating microRNAs associated with inflammation, a hedonic response (sucrose intake), forced swim test (FST), corticosterone levels...
Major depressive disorder (MDD) affects more than 350 million people worldwide, and there is currently no laboratory test to diagnose it. This pilot study aimed identify potential biomarkers in peripheral blood mononuclear cells (PBMCs) from MDD patients.We used tandem mass tagging coupled synchronous precursor selection (mass spectrometry) obtain the differential proteomic profile a pool of PBMCs patients healthy subjects, quantitative PCR assess gene expression differentially expressed...
Canine parvovirus type II (CPV-2) infection induces canine parvoviral enteritis (CPE), which in turn promotes sepsis and systemic inflammatory response syndrome (SIRS). Mortality this disease is usually registered within 48-72 h post-hospitalization, the critical period of illness. It has been recently described that use an immunomodulator, whose major component monomeric ubiquitin (mUb) without last two glycine residues (Ub∆GG), pediatric human patients with augments survival. known CXCR4...
Transferon, a biotherapeutic agent that has been used for the past 2 decades diseases with an inflammatory component, approved by regulatory authorities in Mexico (COFEPRIS) treatment of patients herpes infection. The active pharmaceutical ingredient (API) Transferon is based on polydispersion peptides have extracted from lysed human leukocytes dialysis process and subsequent ultrafiltration step to select molecules below 10 kDa. To physicochemically characterize drug product, we developed...
Labor is regarded as increased myometrial activity with a regular contractility pattern. At this final stage of pregnancy, quiescence lost, accompanied by altered immune homeostasis. It well known that the interleukin (IL)-10 family cytokines modulates immunological responses mainly in epithelial cells, including endometrium. To investigate their inflammatory profile during labor, we performed longitudinal study group healthy pregnant women (<i>n</i> = 20) uncomplicated...
Brucellosis infection causes non-specific symptoms such as fever, chills, sweating, headaches, myalgia, arthralgia, anorexia, fatigue, and mood disorders. In mouse models, it has been associated with increased levels of IL-6, TNF-α, IFN-γ, a decrease in serotonin dopamine within the hippocampus, induced loss muscle strength equilibrium, anxiety hopelessness. Imipramine (ImiP), tricyclic antidepressant, is used to alleviate neuropathic pain. This study evaluated effects ImiP on Balb/c mice...
Murine leprosy, caused by Mycobacterium lepraemurium (MLM), is a chronic disease that closely resembles human leprosy. Even though this does not directly involve the nervous system, we investigated possible effect on working memory during infection in Balb/c mice. We evaluated alterations dorsal region of hippocampus and measured peripheral levels cytokines at 40, 80, 120 days post-infection. To evaluate memory, used T-maze while morphometric analysis was conducted regions CA1, CA2, CA3,...
As etiological agents of malaria disease, Plasmodium spp. parasites are responsible for one the most severe global health problems occurring in tropical regions world. This work involved compiling marine cyanobacteria metabolites reported scientific literature that exhibit antiplasmodial activity. Out 111 compounds mined and 106 tested, two showed activity at very low concentrations, with IC50 0.1 1.5 nM (peptides: dolastatin 10 lyngbyabellin A, 1.9% total tested). Examples chemical...
Major depressive disorder (MDD) is a mood that has become global health emergency according to the World Health Organization (WHO). It affects 280 million people worldwide and leading cause of disability financial loss. Patients with MDD present immunoendocrine alterations like cortisol resistance inflammation, which are associated in neurotransmitter metabolism. There currently numerous therapeutic options for patients MDD; however, some studies suggest high rate failure. multiple...