A5036041032- Ocular Surface and Contact Lens
- Corneal Surgery and Treatments
- Allergic Rhinitis and Sensitization
- Ocular Infections and Treatments
- Immune Cell Function and Interaction
- Pharmacological Effects of Natural Compounds
- Immunotherapy and Immune Responses
- Ocular Diseases and Behçet’s Syndrome
- Asthma and respiratory diseases
- Morinda citrifolia extract uses
- Urticaria and Related Conditions
- T-cell and B-cell Immunology
- Pediatric health and respiratory diseases
- Tuberculosis Research and Epidemiology
- Immune Response and Inflammation
- Herpesvirus Infections and Treatments
- Dermatology and Skin Diseases
- Mycobacterium research and diagnosis
- Occupational Health and Safety in Workplaces
- COVID-19 Clinical Research Studies
- Diabetes and associated disorders
- Retinal and Optic Conditions
- Systemic Lupus Erythematosus Research
- Immunodeficiency and Autoimmune Disorders
- Salivary Gland Disorders and Functions
Institute of Ophthalmology
2013-2025
Universidad Nacional Autónoma de México
2014-2025
Sakarya University
2022
Cincinnati Children's Hospital Medical Center
2022
Siberian State Medical University
2022
Istanbul University
2022
Inserm
2017
Laboratoire Stress Oxydant et Pathologies Métaboliques
2017
Université d'Angers
2017
Ocular Proteomics (United States)
2007-2016
Allergic rhinitis (AR) has considerable impact on the general health of individuals. Therefore, treatment trials should include an evaluation quality life. We aimed to determine changes in life moderate/severe AR patients treated with standard addition dialyzable leukocyte extract (DLE), a peptide-based immunomodulator. In prospective, non-controlled trial, DLE was added regimen for AR. administered orally at 2 mg per day 5 days, followed by 4 week weeks, and then weeks. The primary...
Introduction: Acute adenoviral conjunctivitis is a disease with mild to severe clinical manifestations. Animal models have provided insight into the role of innate immune system in damage, but human response at ocular surface remains poorly understood. Therefore, this study aimed establish relationship between tear cytokine levels and severity patients epidemic keratoconjunctivitis (EKC). Methods: Fourteen consecutive EKC, confirmed HAdV8 infection, were included. Ocular characteristics...
Corneal infections are frequent and potentially vision-threatening diseases, despite the significance of immunological response in animal models microbial keratitis (MK), it remains unclear humans. The aim this study was to describe cytokine profile tears patients with MK. Characteristics ocular lesions such as size epithelial defect, stromal infiltration, hypopyon were analyzed. Immunological evaluation included determination interleukine (IL)-1β, IL-6, IL-8, IL-10, IL-12 tumor necrosis...
Over a period of eight years, were assessed the main types airborne pollen in Mexico City (a tropical region). We established calendar and we evaluated associations between aeroallergens allergic diseases children treated at hospitals. A Hirst-type volumetric spore trap was placed an open area within Chapultepec Forest, records obtained during flowering plants. total 502 patients 1 17 years old evaluated. The diagnosed by skin testing with extracts tree pollen, grass weeds. During monitoring...
Amniotic membrane (AM) is the inner layer of placenta, which in contact with fetus; it has been used for transplantation ocular surface diseases. It reported that amniotic promotes epithelialization, inhibits angiogenesis and diminishes inflammation. A persistent epithelial defect delay wound healing caused by infiltrating inflammatory cells into cornea successfully its treatment, however mechanism action inhibiting inflammation not well understood. This study was aimed at determining...
The aim of the study was to evaluate effect 3 subconjunctival bevacizumab injections in patients with an early corneal pterygium recurrence.This a nonrandomized single center trial. Patients recurrence were selected. All received (2.5 mg/0.1 mL) (basal, 2 and 4 weeks) area pterygium. corneal-conjunctival neovascularization areas opacification each determined using digital slit lamp pictures.Thirty-eight enrolled into study; all injected within months diagnosed recurrence. Interestingly, had...
Nosocomial invasive fungal infections, particularly aspergillosis, are an increasing problem in immunocompromised patients. The presented study evaluates diversity and the presence of Aspergillus air samples from two hospitals.Over course one year (rainy dry seasons), was sampled three areas hospitals (1 2) using a single-stage Andersen viable particle sampler (Thermo Scientific, Waltham, MA, USA). fungi were identified by macro- micromorphology, number colony forming units (CFU)/m(3) their...
Major depressive disorder (MDD) is a global health issue that affects 350 million people of all ages. Although between 2% and 5.6% affected individuals are adolescents, research on young patients limited. The inflammatory response contributes to the onset depression, in adult MDD patients, symptom severity has been linked chemokine levels.To determine differences circulatory levels chemokines healthy volunteers (HVs) adolescents with MDD, assess changes induced by fluoxetine consume.The 22...
<h3>Aim:</h3> To evaluate the frequency, phenotype and potential function of CD57+ T cell subsets in patients with pars planitis. <h3>Methods:</h3> CD4+CD57+ CD8+CD57+ cells were quantitated peripheral blood from 15 planitis healthy controls. CCR7, CD27, CD28, CD45RA, CD45RO, intracellular IFN-γ, IL-4, perforin granzyme-A expression assessed by flow cytometry. <h3>Results:</h3> increased (p = 0.002). The majority CCR7−CD27−CD28−CD45RO+, while most CCR7−CD27−CD28−CD45RA+. number positive for...
Age-related macular degeneration (AMD) is a complex, progressive degenerative retinal disease. Retinal pigment epithelial (RPE) cells play an important role in the immune defense of eye and their dysfunction leads to irreversible photoreceptors. Genetic factors, chronic inflammation, oxidative stress have been implicated AMD pathogenesis. Oxidative causes RPE injury, resulting inflammatory response cell death. The Y402H polymorphism complement factor H (CFH) protein risk for AMD. However,...
In some chronic pathological conditions, antigen persistence activates and expands the CD4+ CD57+ T-cell subset. The host immune response against tuberculosis infection is maintained through continuous presence of antigen-stimulated effector/memory helper T cells. To determine whether cells were also expanded in human tuberculosis, we analysed (by flow cytometry) phenotype peripheral blood from 30 patients healthy controls. We observed a significant increase subset comparison to controls (P...
Hyper-IgE syndrome (HIES) is a rare primary immunodeficiency characterized by elevated levels of immunoglobulin E (IgE), eczematous dermatitis, cold abscesses, and recurrent infections the lung skin caused Staphylococcus aureus . The dominant form nonimmunologic features including skeletal, connective tissue, pulmonary abnormalities in addition to eczema. Omalizumab humanized recombinant monoclonal antibody against IgE. Several studies reported clinical improvement with omalizumab patients...
Age-related macular degeneration (AMD) involves degenerative and neovascular alteration in the region of retina resulting central vision loss. AMD can be classified into dry (dAMD) wet (wAMD). There is no established treatment for dAMD, therapies available wAMD have limited success. Diagnosis early stages difficult due to absence clinical symptoms. Currently, imaging tests are used diagnosis AMD, but cannot predict course. The limitations establishing a led exploration innovative more...
The aim of this work was to determine the presence galectin-10 in nasal lavage fluid (NLF) patients with aspirin-sensitive respiratory disease (ASRD) before and after challenge L-ASA (aspirin) by ELISA. Fifteen ASRD patients, ten aspirin-tolerant asthmatics (ATA), fifteen healthy controls (HC) were studied. baseline Galectin-10 PBMC determined using real time PCR. evaluated tissue polyps western blot. Our results showed a lower expression than ATA controls. However, higher concentration NLF...
Allergic conjunctivitis (AC) is one of the most common eye disorders in ophthalmology. In mice models, it has been suggested that control allergic a delicate balance between Tregs and inflammatory migrating effector cells. Our aim was to evaluate frequency homing receptors expressing cells peripheral blood mononuclear (PBMC) from patients with perennial (PAC). The analyses phenotypic markers on CD4+ T both soluble or intracellular cytokines were performed by flow cytometry. CD4+CD25+ 15...
The implementation and validation of anti-SARS-CoV-2 IgG serological assays are reported in this paper. S1 RBD proteins were used to coat ELISA plates, several secondary antibodies served as reporters. initially validated with 50 RT-PCR positive COVID-19 sera, which showed high titers mainly IgG1 isotype, followed by IgG3. Low or no IgG2 IgG4 detected. Then, the RBD/IgG assay was further 887 serum samples from individuals collected at different times, including 7, 14, 21, 40 days after onset...