A5103173370- Epigenetics and DNA Methylation
- Protein Tyrosine Phosphatases
- Acute Myeloid Leukemia Research
- Cancer Genomics and Diagnostics
- Gas Sensing Nanomaterials and Sensors
- Histone Deacetylase Inhibitors Research
- MicroRNA in disease regulation
- Biological Research and Disease Studies
- Hematopoietic Stem Cell Transplantation
- ZnO doping and properties
- Biocrusts and Microbial Ecology
- Reproductive System and Pregnancy
- Neuroscience and Music Perception
- Wnt/β-catenin signaling in development and cancer
- Extracellular vesicles in disease
- Immune Cell Function and Interaction
- Ubiquitin and proteasome pathways
- Inflammasome and immune disorders
- Supercapacitor Materials and Fabrication
- Immune cells in cancer
- Single-cell and spatial transcriptomics
- PI3K/AKT/mTOR signaling in cancer
- Algal biology and biofuel production
- Transition Metal Oxide Nanomaterials
- Functional Brain Connectivity Studies
Zhejiang Chinese Medical University
2025
Zhejiang University
2025
University of Indianapolis
2022-2024
Midwestern University
2023-2024
Tianjin Medical University General Hospital
2024
Indiana University – Purdue University Indianapolis
2016-2024
Northwestern University
2022-2024
Indiana University Indianapolis
2023-2024
Icahn School of Medicine at Mount Sinai
2024
Mount Sinai Health System
2024
Abstract Clonal hematopoiesis of indeterminate potential (CHIP) increases with age and is associated increased risks hematological malignancies. While TP53 mutations have been identified in CHIP, the molecular mechanisms by which mutant p53 promotes hematopoietic stem progenitor cell (HSPC) expansion are largely unknown. Here we discover that confers a competitive advantage to HSPCs following transplantation HSPC after radiation-induced stress. Mechanistically, interacts EZH2 enhances its...
<title>Abstract</title> The advanced single-microbe RNA sequencing (smRNA-seq) technique addresses the pressing need to understand complexity and diversity of microbial communities, as well distinct states defined by different gene expression profiles. Current analyses smRNA-seq data heavily rely on integrity reference genomes within queried microbiota. However, establishing a comprehensive collection or sets remains significant challenge for most real-world ecosystems. Here, we developed an...
Abstract Microbial single‐cell RNA‐seq (mscRNA‐seq) can achieve resolution at the cellular level, enhancing understanding of microbial communities. However, current high‐throughput mscRNA‐seq methods are limited by multiple centrifugation steps, which lead to loss and bias. smGel‐seq is reported, a single‐microbe RNA sequencing method for clinical microbiome samples that employs hydrogel beads encapsulate individual microbes reduce input requirements. In this method, novel microchannel array...
Wire array templates have been utilized for fabricating various three-dimensional tubular structure devices, such as solar cells, batteries and supercapacitors, well electronic photonic devices. It is necessary to remove the by using post-treatments wet chemical etching, decomposition, or Kirkendall approaches. However, it remains a challenge ensure integrity, mechanical soundness, purity during template removal process, which affects functional robustness of enabled In this work, utilizing...
Background Traditional Chinese opera, such as Pingju , requires actors to master sophisticated performance skills and cultural knowledge, potentially influencing brain function. This study aimed explore the effects of long-term opera training on dynamic amplitude low-frequency fluctuation (dALFF) functional connectivity (dFC). Methods Twenty professional well-trained twenty demographically matched untrained subjects were recruited. Resting-state magnetic resonance imaging (fMRI) data...
Abstract Receptor tyrosine kinase KIT is frequently activated in acute myeloid leukemia (AML). While high PRL2 (PTP4A2) expression correlated with activation of SCF/KIT signaling AML, the underlying mechanisms are not fully understood. We discovered that inhibition significantly reduces burden oncogenic KIT-driven and extends leukemic mice survival. enhances cells, promoting their proliferation found dephosphorylates CBL at 371 inhibits its activity toward KIT, leading to decreased...
Abstract Review: 56 refs.